PMID- 30574801
OWN - NLM
STAT- MEDLINE
DCOM- 20190620
LR  - 20221207
IS  - 1876-2891 (Electronic)
IS  - 1876-2883 (Linking)
VI  - 10
IP  - 2
DP  - 2019 Mar 13
TI  - Effects of long-term administration of Lactobacillus reuteri DSM-17938 on 
      circulating levels of 5-HT and BDNF in adults with functional constipation.
PG  - 137-147
LID - 10.3920/BM2018.0050 [doi]
AB  - Accumulated evidence shows that some probiotic strains ameliorate functional 
      constipation (FC) via the modulation of specific gastrointestinal peptide 
      pathways. The aims of this study were to investigate: (1) the effects of 
      long-term administration of Lactobacillus reuteri (LR) DSM 17938 on the serum 
      levels of serotonin (5-HT) and brain-derived neurotrophic factor (BDNF); (2) the 
      possible link between 5-HT, BDNF, and specific constipation-related symptoms; (3) 
      whether genetic variability at the 5-HTT gene-linked polymorphic region 
      (5-HTTLPR) and BDNF Val66Met loci could be associated with serum 5-HT and BDNF 
      variations. LR DSM 17938 was administered to 56 FC patients for 105 days in a 
      randomised, double-blind manner. The fasting blood samples were collected during 
      the randomisation visit (V(1)), at day 15 (induction period, V(2)), day 60 
      (intermediate evaluation, V(3)), and day 105 (V(4)) and the Constipaq 
      questionnaire (the sum of Constipation Scoring System (CSS) and patient 
      assessment constipation quality of life (PAC-QoL)) was administered. A group of 
      healthy subjects was enrolled as controls (HC). At V1, the mean serum 5-HT level 
      in the whole patient group was significantly higher (P=0.027) than in HC 
      subjects, while serum BDNF did not. At the end of probiotic administration (V4), 
      5-HT and BDNF levels were significantly lower than the initial values (V1) 
      (P=0.008 and P=0.015, respectively). 5-HT and BDNF serum concentration were 
      significantly associated (r=0.355; P=0.007). Neither 5-HT nor BDNF serum levels 
      correlated with the CSS item scores and with the PAC-QoL. Lastly, the regression 
      analysis demonstrated that the presence of the S allele of the 5-HTTLPR accounted 
      for the reduction in the 5-HT concentration at V4. In conclusion, the long-term 
      administration of LR DSM 17938 demonstrated that such a probiotic strain could 
      improve FC by affecting 5-HT and BDNF serum concentrations.
FAU - Riezzo, G
AU  - Riezzo G
AD  - 1 Laboratory of Nutritional Pathophysiology, National Institute of Digestive 
      Diseases I.R.C.C.S. 'Saverio de Bellis', Via Turi 27, 70013 Castellana Grotte, 
      Bari, Italy.
FAU - Chimienti, G
AU  - Chimienti G
AD  - 2 Department of Biosciences, Biotechnology and Biopharmaceutics, University of 
      Bari, Via Orabona 4, 70100 Bari, Italy.
FAU - Orlando, A
AU  - Orlando A
AD  - 1 Laboratory of Nutritional Pathophysiology, National Institute of Digestive 
      Diseases I.R.C.C.S. 'Saverio de Bellis', Via Turi 27, 70013 Castellana Grotte, 
      Bari, Italy.
FAU - D'Attoma, B
AU  - D'Attoma B
AD  - 1 Laboratory of Nutritional Pathophysiology, National Institute of Digestive 
      Diseases I.R.C.C.S. 'Saverio de Bellis', Via Turi 27, 70013 Castellana Grotte, 
      Bari, Italy.
FAU - Clemente, C
AU  - Clemente C
AD  - 1 Laboratory of Nutritional Pathophysiology, National Institute of Digestive 
      Diseases I.R.C.C.S. 'Saverio de Bellis', Via Turi 27, 70013 Castellana Grotte, 
      Bari, Italy.
FAU - Russo, F
AU  - Russo F
AD  - 1 Laboratory of Nutritional Pathophysiology, National Institute of Digestive 
      Diseases I.R.C.C.S. 'Saverio de Bellis', Via Turi 27, 70013 Castellana Grotte, 
      Bari, Italy.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20181221
PL  - Netherlands
TA  - Benef Microbes
JT  - Beneficial microbes
JID - 101507616
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 333DO1RDJY (Serotonin)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood/genetics
MH  - Constipation/pathology/*therapy
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Limosilactobacillus reuteri/*growth & development
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Probiotics/*administration & dosage
MH  - Quality of Life
MH  - Serotonin/*blood
MH  - Serotonin Plasma Membrane Transport Proteins/genetics
MH  - Serotonin Receptor Agonists/*blood
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - DSM 17938
OT  - 5-HT
OT  - BDNF
OT  - constipation
OT  - probiotics
EDAT- 2018/12/24 06:00
MHDA- 2019/06/21 06:00
CRDT- 2018/12/22 06:00
PHST- 2018/12/24 06:00 [pubmed]
PHST- 2019/06/21 06:00 [medline]
PHST- 2018/12/22 06:00 [entrez]
AID - 10.3920/BM2018.0050 [doi]
PST - ppublish
SO  - Benef Microbes. 2019 Mar 13;10(2):137-147. doi: 10.3920/BM2018.0050. Epub 2018 
      Dec 21.