PMID- 30575251 OWN - NLM STAT- MEDLINE DCOM- 20200330 LR - 20200330 IS - 1463-1326 (Electronic) IS - 1462-8902 (Linking) VI - 21 IP - 5 DP - 2019 May TI - Dynamic changes in insulin and glucagon during disease progression in rhesus monkeys with obesity-related type 2 diabetes mellitus. PG - 1111-1120 LID - 10.1111/dom.13624 [doi] AB - AIMS: To investigate the progression of obesity-related type 2 diabetes mellitus (T2DM) in rhesus monkeys, especially dynamic changes in insulin and glucagon. MATERIALS AND METHODS: We followed a cohort of 52 rhesus monkeys for 7 years throughout the progression of obesity-related T2DM. Intravenous glucose tolerance tests were performed every 6 months to evaluate dynamic changes in glucose, insulin and glucagon levels. RESULTS: Obesity in rhesus monkeys increased the overall mortality and T2DM morbidity. During the progression of T2DM, glucagon remained consistently elevated, while insulin initially increased in compensation but then dropped to below normal levels when the monkeys developed overt T2DM. After a glucose challenge, both the first and second phases of insulin secretion increased during the early stage of T2DM; in later stages the first phase was delayed and the second phase was diminished. CONCLUSION: Our findings showed that, beside the decreased insulin level, hyperglucagonaemia also plays an important role in the development of T2DM. CI - (c) 2018 John Wiley & Sons Ltd. FAU - Wang, Can AU - Wang C AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. FAU - Xiao, Yao AU - Xiao Y AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. FAU - Wang, Jue AU - Wang J AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. FAU - Hou, Ning AU - Hou N AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. FAU - Cui, Weiyi AU - Cui W AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. FAU - Hu, Xiaomin AU - Hu X AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. FAU - Zeng, Fanxin AU - Zeng F AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. FAU - Yuan, Ye AU - Yuan Y AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. FAU - Ma, Dongwei AU - Ma D AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. FAU - Sun, Xueting AU - Sun X AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. FAU - Zhang, Yan AU - Zhang Y AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. AD - State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking-Tsinghua Center for Life Sciences, Beijing, China. FAU - Zheng, Wen AU - Zheng W AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. FAU - Liu, Yuli AU - Liu Y AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. FAU - Shang, Haibao AU - Shang H AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. FAU - Chen, Liangyi AU - Chen L AD - Institute of Molecular Medicine, Peking University, Beijing, China. FAU - Xiao, Rui-Ping AU - Xiao RP AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. AD - State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking-Tsinghua Center for Life Sciences, Beijing, China. FAU - Zhang, Xiuqin AU - Zhang X AUID- ORCID: 0000-0001-8692-7146 AD - Institute of Molecular Medicine, Peking University, Beijing, China. AD - Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190122 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 RN - 0 (Blood Glucose) RN - 0 (Insulin) RN - 9007-92-5 (Glucagon) SB - IM MH - Animals MH - Blood Glucose/analysis/metabolism MH - Diabetes Mellitus, Experimental/blood/etiology/pathology MH - Diabetes Mellitus, Type 2/*blood/etiology/*pathology MH - Disease Progression MH - Glucagon/*blood MH - Glucose Tolerance Test MH - Insulin/*blood MH - Macaca mulatta MH - Male MH - Monitoring, Physiologic/methods/veterinary MH - Obesity/*blood/complications/*pathology OTO - NOTNLM OT - continuous glucose monitoring OT - glucagon OT - insulin secretion OT - type 2 diabetes EDAT- 2018/12/24 06:00 MHDA- 2020/03/31 06:00 CRDT- 2018/12/22 06:00 PHST- 2018/04/03 00:00 [received] PHST- 2018/12/17 00:00 [revised] PHST- 2018/12/17 00:00 [accepted] PHST- 2018/12/24 06:00 [pubmed] PHST- 2020/03/31 06:00 [medline] PHST- 2018/12/22 06:00 [entrez] AID - 10.1111/dom.13624 [doi] PST - ppublish SO - Diabetes Obes Metab. 2019 May;21(5):1111-1120. doi: 10.1111/dom.13624. Epub 2019 Jan 22.