PMID- 30575339
OWN - NLM
STAT- MEDLINE
DCOM- 20200413
LR  - 20210225
IS  - 1099-0496 (Electronic)
IS  - 8755-6863 (Print)
IS  - 1099-0496 (Linking)
VI  - 54
IP  - 3
DP  - 2019 Mar
TI  - Serum neurotrophins at birth correlate with respiratory and neurodevelopmental 
      outcomes of premature infants.
PG  - 303-312
LID - 10.1002/ppul.24218 [doi]
AB  - OBJECTIVE: Preterm birth is a significant cause of infant morbidity and 
      mortality, which are primarily the result of respiratory and neurodevelopmental 
      complications. However, no objective biomarker is currently available to predict 
      at birth the risk and severity of such complications. Thus, we sought to 
      determine whether serum neurotrophins concentrations measured at birth correlate 
      with risk for later development of bronchopulmonary dysplasia (BPD) and long-term 
      neurodevelopmental outcomes. METHODS: This study prospectively included 223 
      newborns admitted to neonatal intensive care units (NICU) and divided into three 
      groups: (i) preterm infants who developed BPD; (ii) preterm infants who did not 
      develop BPD; (iii) term infants. An exploratory cohort was enrolled in West 
      Virginia, followed by a validation cohort recruited in four NICUs in Ohio. 
      Specimens for serum and tracheal neurotrophins concentrations were collected 
      within 48 h of admission. Infants requiring a fraction of inspired oxygen >0.21 
      for at least 28 days were diagnosed with BPD. Neurodevelopmental outcomes were 
      extrapolated from Bayley Scales of Infant Development-Third Edition (BSID-III) 
      administered at the 24-month follow-up visit. RESULTS: Serum brain-derived 
      neurotrophic factor (BDNF) concentration at birth had significant negative 
      correlation with later diagnosis of BPD (P = 0.011) and with duration of invasive 
      ventilation and oxygen supplementation (P = 0.009 and 0.015, respectively). Serum 
      nerve growth factor (NGF) concentration at birth had significant positive 
      correlation with BSID-III cognitive and language composite scores at 24 months 
      (P < 0.001 and 0.010, respectively). CONCLUSIONS: These data suggest that serum 
      neurotrophins concentrations measured at birth provide prognostic information on 
      subsequent respiratory and neurodevelopmental outcomes.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Simpson, Samantha L
AU  - Simpson SL
AD  - Lerner Research Institute, Cleveland Clinic Foundation, Center for Pediatric 
      Research, Cleveland, Ohio.
FAU - Grayson, Stephanie
AU  - Grayson S
AD  - Department of Pediatrics, West Virginia University, Morgantown, West Virginia.
FAU - Peterson, Jennifer H
AU  - Peterson JH
AD  - Lerner Research Institute, Cleveland Clinic Foundation, Center for Pediatric 
      Research, Cleveland, Ohio.
FAU - Moore, John J
AU  - Moore JJ
AD  - Department of Pediatrics, MetroHealth Medical Center, Cleveland, Ohio.
FAU - Mhanna, Maroun J
AU  - Mhanna MJ
AD  - Department of Pediatrics, MetroHealth Medical Center, Cleveland, Ohio.
FAU - Perez, Miriam K
AU  - Perez MK
AD  - Lerner Research Institute, Cleveland Clinic Foundation, Center for Pediatric 
      Research, Cleveland, Ohio.
FAU - Rezaee, Fariba
AU  - Rezaee F
AD  - Lerner Research Institute, Cleveland Clinic Foundation, Center for Pediatric 
      Research, Cleveland, Ohio.
FAU - Piedimonte, Giovanni
AU  - Piedimonte G
AUID- ORCID: 0000-0003-1640-1928
AD  - Lerner Research Institute, Cleveland Clinic Foundation, Center for Pediatric 
      Research, Cleveland, Ohio.
LA  - eng
GR  - K08 AI112781/AI/NIAID NIH HHS/United States
GR  - R01 HL061007/HL/NHLBI NIH HHS/United States
GR  - R01 HL148057/HL/NHLBI NIH HHS/United States
GR  - RO1 HL-061007/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20181221
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*blood/metabolism
MH  - Bronchopulmonary Dysplasia/*epidemiology
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature/*blood/metabolism
MH  - Infant, Premature, Diseases/*epidemiology
MH  - Intensive Care Units, Neonatal
MH  - Male
MH  - Nerve Growth Factor/*blood/metabolism
MH  - Neurodevelopmental Disorders/*epidemiology
MH  - Ohio
MH  - Prognosis
MH  - Trachea/metabolism
MH  - West Virginia/epidemiology
PMC - PMC7306099
MID - NIHMS1570577
OTO - NOTNLM
OT  - biomarkers
OT  - bronchopulmonary dysplasia (BPD)
OT  - developmental biology
OT  - neonatal pulmonary medicine
COIS- CONFLICT OF INTEREST None.
EDAT- 2018/12/24 06:00
MHDA- 2020/04/14 06:00
PMCR- 2020/06/21
CRDT- 2018/12/22 06:00
PHST- 2018/08/23 00:00 [received]
PHST- 2018/11/03 00:00 [accepted]
PHST- 2018/12/24 06:00 [pubmed]
PHST- 2020/04/14 06:00 [medline]
PHST- 2018/12/22 06:00 [entrez]
PHST- 2020/06/21 00:00 [pmc-release]
AID - 10.1002/ppul.24218 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 2019 Mar;54(3):303-312. doi: 10.1002/ppul.24218. Epub 2018 Dec 
      21.