PMID- 30577228
OWN - NLM
STAT- MEDLINE
DCOM- 20190208
LR  - 20190215
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 50
IP  - 10
DP  - 2018 Dec
TI  - Objective Versus Subjective Assessment of Functional Status in Candidates for 
      Liver Transplantation.
PG  - 3508-3512
LID - S0041-1345(18)30736-X [pii]
LID - 10.1016/j.transproceed.2018.06.020 [doi]
AB  - INTRODUCTION: and aim. Poor functional status is associated with increased 
      mortality in cirrhosis patients awaiting liver transplantation (LT); however, the 
      optimal assessment of functional status remains unknown. This study sought to 
      determine the relationship between 6-minute walk distance (6MWD) and Karnofsky 
      Performance Status (KPS) and their association with waitlist mortality in LT 
      candidates. MATERIAL AND METHODS: Two hundred seventy-eight consecutive patients 
      listed for LT were included. KPS and 6MWD were assessed at the time of 
      evaluation. KPS was recorded as a percentage from 0 to 100, with 0 representing 
      death and 100 representing no presence of disease. Patients were followed from 
      time of listing until transplantation, death, removal from the waitlist or end of 
      the study period. RESULTS: The mean KPS and 6MWD were 77.4 +/- 13.5 and 323.6 +/- 
      163.9 m, respectively. A mild correlation between 6MWD and KPS was demonstrated 
      (Spearman rho = 0.4317, P < .0001). KPS was significantly lower in patients with 
      6MWD < 250 meters (P < .0001). The 6MWD was significantly lower in patients who 
      suffered waitlist mortality (266.1 vs 331.8 m, P = .05). CONCLUSION: In 
      conclusion, 6MWD is a better predictor of waitlist mortality than KPS score in 
      candidates for LT. The addition of 6MWD as a standard assessment may help to 
      identify patients at risk of dying on the waitlist.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - McNally, B B
AU  - McNally BB
AD  - Midwestern University Arizona College of Osteopathic Medicine, Glendale, AZ.
FAU - Carey, E J
AU  - Carey EJ
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic in Arizona, Phoenix, AZ. 
      Electronic address: Carey.elizabeth@Mayo.edu.
LA  - eng
PT  - Journal Article
DEP - 20180622
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - *Karnofsky Performance Status
MH  - *Liver Transplantation/mortality
MH  - Male
MH  - Middle Aged
MH  - *Patient Selection
MH  - Retrospective Studies
MH  - Waiting Lists/*mortality
MH  - *Walking
EDAT- 2018/12/24 06:00
MHDA- 2019/02/09 06:00
CRDT- 2018/12/23 06:00
PHST- 2018/05/30 00:00 [received]
PHST- 2018/06/19 00:00 [accepted]
PHST- 2018/12/23 06:00 [entrez]
PHST- 2018/12/24 06:00 [pubmed]
PHST- 2019/02/09 06:00 [medline]
AID - S0041-1345(18)30736-X [pii]
AID - 10.1016/j.transproceed.2018.06.020 [doi]
PST - ppublish
SO  - Transplant Proc. 2018 Dec;50(10):3508-3512. doi: 
      10.1016/j.transproceed.2018.06.020. Epub 2018 Jun 22.