PMID- 30577585
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Dec 21
TI  - Potential Application of Prunus armeniaca L. and P. domestica L. Leaf Essential 
      Oils as Antioxidant and of Cholinesterases Inhibitors.
LID - 10.3390/antiox8010002 [doi]
LID - 2
AB  - The aim of this work is to investigate the in vitro acetylcholinesterase (AChE) 
      and butyrycholinesterase (BChE) inhibitory activities of essential oils obtained 
      by hydrodistillation from the leaves of Prunus armeniaca and P. domestica in 
      relation to their composition, analysed by Gas Chromatography(-)Flame Ionization 
      Detector (GC-FID) and Gas Chromatography-Mass Spectrometry (GC-MS) analyses, at 
      different times. Moreover, considering the role of free radicals in the 
      progression of neurodegenerative disorders, the antioxidant properties of 
      essential oils were investigated by using, 
      2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), 
      2,2-diphenyl-1-picrylhydrazyl (DPPH), and beta-carotene bleaching tests. The 
      relative antioxidant capacity index (RACI) was used to achieve more comprehensive 
      comparison between analysed antioxidant effects of essential oils. P. armeniaca 
      oils were more active than P. domestica oils against AChE. Against BChE, the most 
      active was the essential oil from P. domestica leaves collected in August with an 
      IC(50) value of 95.80 mug/mL. This oil exerted the highest inhibitory activity of 
      lipid peroxidation with IC(50) values of 11.15 and 11.39 mug/mL after 30 and 60 
      min of incubation, respectively. All samples demonstrated a remarkable ABTS 
      radicals scavenging activity, with IC(50) values in the range 0.45(-)0.57 mug/mL in 
      comparison to the positive control, ascorbic acid.
FAU - Bonesi, Marco
AU  - Bonesi M
AD  - Department of Pharmacy, Health Science and Nutrition, University of Calabria, Via 
      Pietro Bucci, 87036 Arcavacata di Rende (CS), Italy. marco.bonesi@unical.it.
FAU - Tenuta, Maria Concetta
AU  - Tenuta MC
AD  - Department of Pharmacy, Health Science and Nutrition, University of Calabria, Via 
      Pietro Bucci, 87036 Arcavacata di Rende (CS), Italy. mary.tn2006@hotmail.it.
FAU - Loizzo, Monica R
AU  - Loizzo MR
AD  - Department of Pharmacy, Health Science and Nutrition, University of Calabria, Via 
      Pietro Bucci, 87036 Arcavacata di Rende (CS), Italy. 
      monica_rosa.loizzo@unical.it.
FAU - Sicari, Vincenzo
AU  - Sicari V
AD  - Department of Agricultural Science, Mediterranean University of Reggio Calabria, 
      Via Graziella, Feo di Vito, 89123 Reggio Calabria, Italy. 
      vincenzo.sicari@unirc.it.
FAU - Tundis, Rosa
AU  - Tundis R
AD  - Department of Pharmacy, Health Science and Nutrition, University of Calabria, Via 
      Pietro Bucci, 87036 Arcavacata di Rende (CS), Italy. rosa.tundis@unical.it.
LA  - eng
PT  - Journal Article
DEP - 20181221
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC6356404
OTO - NOTNLM
OT  - Prunus species
OT  - antioxidant
OT  - essential oil
OT  - leaves
OT  - neuroprotection
COIS- The authors declare no conflict of interest.
EDAT- 2018/12/24 06:00
MHDA- 2018/12/24 06:01
PMCR- 2018/12/21
CRDT- 2018/12/23 06:00
PHST- 2018/11/29 00:00 [received]
PHST- 2018/12/11 00:00 [revised]
PHST- 2018/12/16 00:00 [accepted]
PHST- 2018/12/23 06:00 [entrez]
PHST- 2018/12/24 06:00 [pubmed]
PHST- 2018/12/24 06:01 [medline]
PHST- 2018/12/21 00:00 [pmc-release]
AID - antiox8010002 [pii]
AID - antioxidants-08-00002 [pii]
AID - 10.3390/antiox8010002 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2018 Dec 21;8(1):2. doi: 10.3390/antiox8010002.