PMID- 30578649
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200108
IS  - 1098-108X (Electronic)
IS  - 0276-3478 (Linking)
VI  - 52
IP  - 1
DP  - 2019 Jan
TI  - Transcriptional regulation of the endocannabinoid system in a rat model of 
      binge-eating behavior reveals a selective modulation of the hypothalamic fatty 
      acid amide hydrolase gene.
PG  - 51-60
LID - 10.1002/eat.22989 [doi]
AB  - OBJECTIVE: Binge-eating episodes are recurrent and are defining features of 
      several eating disorders. Thus binge-eating episodes might influence eating 
      disorder development of which exact underlying mechanisms are still largely 
      unknown. METHODS: Here we focused on the transcriptional regulation of the 
      endocannabinoid system, a potent regulator of feeding behavior, in relevant rat 
      brain regions, using a rat model in which a history of intermittent food 
      restriction and a frustration stress induce binge-like palatable food 
      consumption. RESULTS: We observed a selective down-regulation of fatty acid amide 
      hydrolase (faah) gene expression in the hypothalamus of rats showing the 
      binge-eating behavior with a consistent reduction in histone 3 acetylation at 
      lysine 4 of the gene promoter. No relevant changes were detected for any other 
      endocannabinoid system components in any brain regions under study, as well as 
      for the other epigenetic mechanisms investigated (DNA methylation and histone 3 
      lysine 27 methylation) at the faah gene promoter. DISCUSSION: Our findings 
      suggest that faah transcriptional regulation is a potential biomarker of 
      binge-eating episodes, with a relevant role in the homeostatic regulation of food 
      intake.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Pucci, Mariangela
AU  - Pucci M
AD  - Faculty of Bioscience and Technology for Food, Agriculture and Environment, 
      University of Teramo, Teramo, Italy.
FAU - Micioni Di Bonaventura, Maria Vittoria
AU  - Micioni Di Bonaventura MV
AUID- ORCID: 0000-0002-8044-1206
AD  - School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy.
FAU - Zaplatic, Elizabeta
AU  - Zaplatic E
AD  - Faculty of Bioscience and Technology for Food, Agriculture and Environment, 
      University of Teramo, Teramo, Italy.
FAU - Bellia, Fabio
AU  - Bellia F
AD  - Faculty of Bioscience and Technology for Food, Agriculture and Environment, 
      University of Teramo, Teramo, Italy.
FAU - Maccarrone, Mauro
AU  - Maccarrone M
AD  - Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
AD  - European Center for Brain Research (CERC)/Santa Lucia Foundation, Rome, Italy.
FAU - Cifani, Carlo
AU  - Cifani C
AUID- ORCID: 0000-0001-6180-828X
AD  - School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy.
FAU - D'Addario, Claudio
AU  - D'Addario C
AUID- ORCID: 0000-0002-1275-098X
AD  - Faculty of Bioscience and Technology for Food, Agriculture and Environment, 
      University of Teramo, Teramo, Italy.
AD  - Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska 
      Institutet, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181222
PL  - United States
TA  - Int J Eat Disord
JT  - The International journal of eating disorders
JID - 8111226
RN  - 0 (Biomarkers)
RN  - 0 (Endocannabinoids)
RN  - EC 3.5.- (Amidohydrolases)
RN  - EC 3.5.1.- (fatty-acid amide hydrolase)
SB  - IM
MH  - *Amidohydrolases/genetics/metabolism
MH  - Animals
MH  - *Binge-Eating Disorder/genetics/metabolism
MH  - Biomarkers
MH  - Bulimia
MH  - *Endocannabinoids
MH  - Feeding Behavior
MH  - Humans
MH  - *Hypothalamus/physiology
MH  - Male
MH  - Rats
OTO - NOTNLM
OT  - binge-eating
OT  - endocannabionid system
OT  - epigenetic mechanisms
OT  - food restriction
OT  - frustration stress
OT  - gene expression
EDAT- 2018/12/24 06:00
MHDA- 2020/01/07 06:00
CRDT- 2018/12/23 06:00
PHST- 2018/08/30 00:00 [received]
PHST- 2018/10/24 00:00 [revised]
PHST- 2018/11/13 00:00 [accepted]
PHST- 2018/12/24 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2018/12/23 06:00 [entrez]
AID - 10.1002/eat.22989 [doi]
PST - ppublish
SO  - Int J Eat Disord. 2019 Jan;52(1):51-60. doi: 10.1002/eat.22989. Epub 2018 Dec 22.