PMID- 3057883
OWN - NLM
STAT- MEDLINE
DCOM- 19890109
LR  - 20190815
IS  - 0272-6386 (Print)
IS  - 0272-6386 (Linking)
VI  - 12
IP  - 6
DP  - 1988 Dec
TI  - An alternative approach for statistical analysis of kidney transplant data: 
      multivariate analysis of single-center experience.
PG  - 524-30
AB  - To avoid the center effect and the possible hidden interactions of multicenter 
      studies, the validity of the Cox Proportional Hazards Model for the analysis of a 
      single-center kidney transplant program was tested, considering 287 renal 
      transplants performed in a 10-year period. The inclusion of type of donor and 
      main immunosuppressive drug as covariates in the model did not violate the 
      proportionality assumption of the Cox model. According to this method, the 
      following covariates were significant in predicting graft survival: cyclosporine, 
      type of donor, good human leukocyte antigen (HLA)-A and HLA-B match (DR data were 
      not considered), highest percentage of reactive antibodies against panel cells, 
      and nephroangiosclerosis as a primary renal disease. Cyclosporine did not 
      significantly improve graft survival in living related donor transplants. 
      Pretransplant blood transfusions, cold ischemia time, and donor ABO blood group 
      were initially significant but dropped out in the step-down procedure. 
      Recipient's age at transplant, cyclosporine, HLA-A and HLA-B match, and 
      nephroangiosclerosis were significant in predicting patient survival. It was 
      concluded that using long-term data of cadaveric and living related renal 
      transplants either on azathioprine or cyclosporine is a valid way to perform 
      multivariate analysis of single-center transplant programs that do not have large 
      samples.
FAU - Madrenas, J
AU  - Madrenas J
AD  - Department of Medicine, University of Alberta, Edmonton, Canada.
FAU - Newman, S
AU  - Newman S
FAU - McGregor, J R
AU  - McGregor JR
FAU - Kovithavongs, T
AU  - Kovithavongs T
FAU - Lakey, W H
AU  - Lakey WH
FAU - Dossetor, J B
AU  - Dossetor JB
FAU - Halloran, P F
AU  - Halloran PF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney 
      Foundation
JID - 8110075
RN  - 0 (Cyclosporins)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Cyclosporins/therapeutic use
MH  - Data Interpretation, Statistical/*standards
MH  - Female
MH  - Graft Survival
MH  - Histocompatibility
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Statistics as Topic
MH  - Tissue Donors
EDAT- 1988/12/01 00:00
MHDA- 1988/12/01 00:01
CRDT- 1988/12/01 00:00
PHST- 1988/12/01 00:00 [pubmed]
PHST- 1988/12/01 00:01 [medline]
PHST- 1988/12/01 00:00 [entrez]
AID - S0272638688001593 [pii]
AID - 10.1016/s0272-6386(88)80105-7 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 1988 Dec;12(6):524-30. doi: 10.1016/s0272-6386(88)80105-7.