PMID- 30580161
OWN - NLM
STAT- MEDLINE
DCOM- 20190215
LR  - 20231213
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 170
DP  - 2019 Apr 15
TI  - The MEK/ERK/CREB signaling pathway is involved in atrazine induced hippocampal 
      neurotoxicity in Sprague Dawley rats.
PG  - 673-681
LID - S0147-6513(18)31325-3 [pii]
LID - 10.1016/j.ecoenv.2018.12.038 [doi]
AB  - Atrazine (ATR) is a commonly used artificial synthetic herbicide world-wide, 
      which has been implicated as a potential threat to human health. Previous studies 
      have demonstrated that exposure to ATR affects hippocampus-dependent learning and 
      memory in rodents, but the exact molecular mechanism remains to be elucidated. In 
      this study, we investigated the effect of ATR on the hippocampus of postnatal day 
      35 male Sprague Dawley (SD) rats administered doses of either 10 or 100 mg/kg 
      body weight (BW)/day of ATR for a period of 30 days. A Morris water maze (MWM) 
      test revealed that ATR treatment impaired memory performance in the spatial probe 
      test, especially amongst the high-dose group. Moreover, analysis by electron 
      microscopy showed that hippocampal neuron ultrastructure in the dentate gyrus 
      (DG) and cornu ammonis 1 (CA1) sub-regions was impaired in the ATR-treated 
      groups. Finally, a downregulation in the mRNA and protein expression levels of 
      members of the MEK/ERK/CREB pathway and downstream factors brain-derived 
      neurotrophic factor (BDNF) and Zif268 was observed in hippocampal tissue 
      following ATR treatment. Taken together, these results suggest that developmental 
      exposure to ATR is able to induce functional and morphological lesions in the 
      hippocampus of SD rats, and that the MEK/ERK/CREB signaling pathway may be 
      involved in this process.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Li, Jianan
AU  - Li J
AD  - Department of Toxicology, College of Public Health, Harbin Medical University, 
      157 Baojian Road, Nan Gang District, Harbin 150081, China.
FAU - Li, Xueting
AU  - Li X
AD  - Department of Toxicology, College of Public Health, Harbin Medical University, 
      157 Baojian Road, Nan Gang District, Harbin 150081, China.
FAU - Bi, Haoran
AU  - Bi H
AD  - Department of Epidemiology, College of Public Health, Harbin Medical University, 
      157 Baojian Road, Nan Gang District, Harbin 150081, China.
FAU - Li, Baixiang
AU  - Li B
AD  - Department of Toxicology, College of Public Health, Harbin Medical University, 
      157 Baojian Road, Nan Gang District, Harbin 150081, China. Electronic address: 
      libaix@ems.hrbmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20181220
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Creb1 protein, rat)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Early Growth Response Protein 1)
RN  - 0 (Egr1 protein, rat)
RN  - 0 (Herbicides)
RN  - QJA9M5H4IM (Atrazine)
SB  - IM
MH  - Animals
MH  - Atrazine/metabolism/*toxicity
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/genetics/metabolism
MH  - Down-Regulation
MH  - Early Growth Response Protein 1/genetics/metabolism
MH  - Herbicides/metabolism/*toxicity
MH  - Hippocampus/*drug effects/*metabolism/ultrastructure
MH  - Humans
MH  - *MAP Kinase Signaling System/genetics
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory/drug effects
MH  - Neurons/drug effects/ultrastructure
MH  - Neurotoxicity Syndromes/etiology/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Atrazine
OT  - Hippocampus
OT  - MEK/ERK/CREB signaling pathway
OT  - Neurotoxicity
EDAT- 2018/12/24 06:00
MHDA- 2019/02/16 06:00
CRDT- 2018/12/24 06:00
PHST- 2018/09/25 00:00 [received]
PHST- 2018/12/10 00:00 [revised]
PHST- 2018/12/12 00:00 [accepted]
PHST- 2018/12/24 06:00 [pubmed]
PHST- 2019/02/16 06:00 [medline]
PHST- 2018/12/24 06:00 [entrez]
AID - S0147-6513(18)31325-3 [pii]
AID - 10.1016/j.ecoenv.2018.12.038 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2019 Apr 15;170:673-681. doi: 
      10.1016/j.ecoenv.2018.12.038. Epub 2018 Dec 20.