PMID- 30581397
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 9
DP  - 2018
TI  - A Conscious Resting State fMRI Study in SLE Patients Without Major 
      Neuropsychiatric Manifestations.
PG  - 677
LID - 10.3389/fpsyt.2018.00677 [doi]
LID - 677
AB  - Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the main causes 
      of death in patients with systemic lupus erythematosus (SLE). Signs and symptoms 
      of NPSLE are heterogeneous, and it is hard to diagnose, and treat NPSLE patients 
      in the early stage. We conducted this study to explore the possible brain 
      activity changes using resting state functional magnetic resonance imaging 
      (rs-fMRI) in SLE patients without major neuropsychiatric manifestations 
      (non-NPSLE patients). We also tried to investigate the possible associations 
      among brain activity, disease activity, depression, and anxiety. In our study, 
      118 non-NPSLE patients and 81 healthy controls (HC) were recruited. Rs-fMRI data 
      were used to calculate the regional homogeneity (ReHo) in all participants. We 
      found decreased ReHo values in the fusiform gyrus and thalamus and increased ReHo 
      values in the parahippocampal gyrus and uncus. The disease activity was 
      positively correlated with ReHo values of the cerebellum and negatively 
      correlated with values in the frontal gyrus. Several brain areas showed 
      correlations with depressive and anxiety statuses. These results suggested that 
      abnormal brain activities might occur before NPSLE and might be the foundation of 
      anxiety and depression symptoms. Early detection and proper treatment of brain 
      dysfunction might prevent the progression to NPSLE. More studies are needed to 
      understand the complicated underlying mechanisms.
FAU - Liu, Shuang
AU  - Liu S
AD  - Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming 
      Medical University, Kunming, China.
AD  - Yunnan Key Laboratory of Laboratory Medicine, Kunming, China.
FAU - Cheng, Yuqi
AU  - Cheng Y
AD  - Yunnan Key Laboratory of Laboratory Medicine, Kunming, China.
AD  - Department of Psychiatry, First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Xie, Zhongqi
AU  - Xie Z
AD  - Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming 
      Medical University, Kunming, China.
FAU - Lai, Aiyun
AU  - Lai A
AD  - Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming 
      Medical University, Kunming, China.
FAU - Lv, Zhaoping
AU  - Lv Z
AD  - Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming 
      Medical University, Kunming, China.
FAU - Zhao, Yueyin
AU  - Zhao Y
AD  - Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming 
      Medical University, Kunming, China.
FAU - Xu, Xiufeng
AU  - Xu X
AD  - Department of Psychiatry, First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Luo, Chunrong
AU  - Luo C
AD  - Magnetic Resonance Imaging Center, The First Hospital of Kunming, Kunming, China.
FAU - Yu, Hongjun
AU  - Yu H
AD  - Magnetic Resonance Imaging Center, The First Hospital of Kunming, Kunming, China.
FAU - Shan, Baoci
AU  - Shan B
AD  - Key Laboratory of Nuclear Analysis, Institute of High Energy Physics, Chinese 
      Academy of Sciences, Beijing, China.
FAU - Xu, Lin
AU  - Xu L
AD  - Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute 
      of Zoology, Chinese Academy of Sciences, Kunming, China.
FAU - Xu, Jian
AU  - Xu J
AD  - Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming 
      Medical University, Kunming, China.
AD  - Yunnan Key Laboratory of Laboratory Medicine, Kunming, China.
LA  - eng
PT  - Journal Article
DEP - 20181207
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC6292957
OTO - NOTNLM
OT  - anxiety
OT  - depression
OT  - disease activity
OT  - regional homogeneity (ReHo)
OT  - resting-state functional magnetic resonance imaging (rs-fMRI)
OT  - systemic lupus erythematosus patients without major neuropsychiatric 
      manifestations (non-NPSLE patients)
EDAT- 2018/12/26 06:00
MHDA- 2018/12/26 06:01
PMCR- 2018/12/07
CRDT- 2018/12/25 06:00
PHST- 2018/05/31 00:00 [received]
PHST- 2018/11/23 00:00 [accepted]
PHST- 2018/12/25 06:00 [entrez]
PHST- 2018/12/26 06:00 [pubmed]
PHST- 2018/12/26 06:01 [medline]
PHST- 2018/12/07 00:00 [pmc-release]
AID - 10.3389/fpsyt.2018.00677 [doi]
PST - epublish
SO  - Front Psychiatry. 2018 Dec 7;9:677. doi: 10.3389/fpsyt.2018.00677. eCollection 
      2018.