PMID- 30582236
OWN - NLM
STAT- MEDLINE
DCOM- 20200908
LR  - 20200908
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 41
IP  - 6
DP  - 2019 Jun
TI  - Prognostic implication of CEACAM1 expression in squamous cell carcinoma of the 
      larynx: Pilot study.
PG  - 1615-1621
LID - 10.1002/hed.25589 [doi]
AB  - BACKGROUND: CEACAM1, a valuable biomarker for several cancers, have remained 
      unexplored up to the present in laryngeal squamous cell carcinoma (LSCC). We 
      aimed to examine CEACAM1 expression and evaluate its combinational clinical 
      significance for the diagnosis or prognosis and treatment decision making in 
      LSCC. METHODS: CEACAM1 expression was assessed by immunohistochemistry in 54 
      LSCCs and evaluate its correlation with clinical and histopathological features. 
      RESULTS: CEACAM subtype 1 (CEACAM1) expression was positive in 50% of the cases. 
      No significant difference was observed in relation to age, gender, tumor size, 
      and tumor stage. CEACAM1 expression correlated with tumor grade, development of 
      local recurrence, node and distant metastasis. Kaplan-Meier survival curves 
      showed that CEACAM1 staining was inversely correlated with both overall and 
      disease-specific 5-year survival. CONCLUSIONS: Our study is the first to 
      demonstrate that CEACAM1 expression is associated with an adverse prognosis in 
      LSCC. CEACAM1 is a valuable biomarker and a promising therapeutic target in LSCC.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Lucarini, Guendalina
AU  - Lucarini G
AUID- ORCID: 0000-0003-3218-5620
AD  - Department of Clinic and Molecular Sciences, Histology, Polytechnic University of 
      Marche, Ancona, Italy.
FAU - Zizzi, Antonio
AU  - Zizzi A
AD  - Department of Biomedical Sciences and Public Health, Section of Pathologic 
      Anatomy and Histopathology, Polytechnic University of Marche, Ancona, Italy.
FAU - Re, Massimo
AU  - Re M
AD  - Department of Otorhinolaryngology, Umberto I University General Hospital, 
      Polytechnic University of Marche, Ancona, Italy.
FAU - Sayeed, Md Abu
AU  - Sayeed MA
AD  - Section of Occupational Medicine, Department of Clinical and Molecular Sciences, 
      Polytechnic University of Marche, Ancona, Italy.
FAU - Di Primio, Roberto
AU  - Di Primio R
AD  - Department of Clinic and Molecular Sciences, Histology, Polytechnic University of 
      Marche, Ancona, Italy.
FAU - Rubini, Corrado
AU  - Rubini C
AD  - Department of Biomedical Sciences and Public Health, Section of Pathologic 
      Anatomy and Histopathology, Polytechnic University of Marche, Ancona, Italy.
LA  - eng
PT  - Journal Article
DEP - 20181223
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD66 antigens)
RN  - 0 (Cell Adhesion Molecules)
SB  - IM
MH  - Aged
MH  - Antigens, CD/*metabolism
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/*mortality
MH  - Cell Adhesion Molecules/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism/*mortality
MH  - Male
MH  - Neoplasm Grading
MH  - Neoplasm Metastasis
MH  - Neoplasm Recurrence, Local/metabolism
MH  - Pilot Projects
MH  - Prognosis
OTO - NOTNLM
OT  - CEACAM1
OT  - immunotherapy
OT  - laryngeal squamous cell carcinoma
OT  - prognostic marker
EDAT- 2018/12/26 06:00
MHDA- 2020/09/09 06:00
CRDT- 2018/12/25 06:00
PHST- 2018/07/11 00:00 [received]
PHST- 2018/10/01 00:00 [revised]
PHST- 2018/12/05 00:00 [accepted]
PHST- 2018/12/26 06:00 [pubmed]
PHST- 2020/09/09 06:00 [medline]
PHST- 2018/12/25 06:00 [entrez]
AID - 10.1002/hed.25589 [doi]
PST - ppublish
SO  - Head Neck. 2019 Jun;41(6):1615-1621. doi: 10.1002/hed.25589. Epub 2018 Dec 23.