PMID- 30583240
OWN - NLM
STAT- MEDLINE
DCOM- 20200806
LR  - 20200806
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 366
DP  - 2019 Mar 15
TI  - Toxicity-based toxicokinetic/toxicodynamic assessment for bioaccumulation of 
      polystyrene microplastics in mice.
PG  - 703-713
LID - S0304-3894(18)31188-9 [pii]
LID - 10.1016/j.jhazmat.2018.12.048 [doi]
AB  - While a large body of literature has shown that microplastics (MPs) are highly 
      likely to be accumulated in marine organisms and terrestrial animals, information 
      about toxicity of MPs in mammal from a mechanistic point of view is more limited. 
      Our paper fills this knowledge gap by assessing polystyrene (PS)-MPs-mice system 
      based on toxicity-based toxicokinetic/toxicodynamic (TBTK/TD) modeling to 
      quantify organ-bioaccumulation and biomarker responses appraised with published 
      dataset. The key TBTK-parameters for mice liver, kidney, and gut posed by 5 or 
      20 mum PS-MPs could be obtained. We found that gut had the highest bioaccumulation 
      factor (BCF) of  approximately 8 exposed to 5 mum PS-MPs with a mean residence time of  approximately 17 days. 
      We showed that threshold concentrations of 5 and 20 mum PS-MPs among the most 
      sensitive biomarkers were 8 +/- 5 (mean +/- SE) and 0.71 +/- 0.14 mug g(-1) bw, 
      respectively, implicating that particle size was likely to affect TK/TD behavior 
      in mice. The mice-based TK parameters and threshold criteria greatly assist in 
      designing robust researches to evaluate MP consumption by humans. We establish a 
      TBTK/TD framework for mechanistically assessing potential from mice size-specific 
      MPs exposure that would offer a tool-kit for extrapolating to humans from health 
      risk assessment perspective.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Yang, Ying-Fei
AU  - Yang YF
AD  - Department of Bioenvironmental Systems Engineering, National Taiwan University, 
      Taipei, 10617, Taiwan, ROC.
FAU - Chen, Chi-Yun
AU  - Chen CY
AD  - Department of Bioenvironmental Systems Engineering, National Taiwan University, 
      Taipei, 10617, Taiwan, ROC.
FAU - Lu, Tien-Hsuan
AU  - Lu TH
AD  - Department of Bioenvironmental Systems Engineering, National Taiwan University, 
      Taipei, 10617, Taiwan, ROC.
FAU - Liao, Chung-Min
AU  - Liao CM
AD  - Department of Bioenvironmental Systems Engineering, National Taiwan University, 
      Taipei, 10617, Taiwan, ROC. Electronic address: cmliao@ntu.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181215
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (Microplastics)
RN  - 0 (Polystyrenes)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Microplastics/*metabolism
MH  - Polystyrenes/*metabolism
MH  - Risk Assessment
MH  - *Toxicokinetics
OTO - NOTNLM
OT  - Bioaccumulations
OT  - Mice
OT  - Microplastics
OT  - Polystyrene
OT  - Toxicokinetic/ toxicodynamic
EDAT- 2018/12/26 06:00
MHDA- 2020/08/07 06:00
CRDT- 2018/12/25 06:00
PHST- 2018/09/12 00:00 [received]
PHST- 2018/11/28 00:00 [revised]
PHST- 2018/12/14 00:00 [accepted]
PHST- 2018/12/26 06:00 [pubmed]
PHST- 2020/08/07 06:00 [medline]
PHST- 2018/12/25 06:00 [entrez]
AID - S0304-3894(18)31188-9 [pii]
AID - 10.1016/j.jhazmat.2018.12.048 [doi]
PST - ppublish
SO  - J Hazard Mater. 2019 Mar 15;366:703-713. doi: 10.1016/j.jhazmat.2018.12.048. Epub 
      2018 Dec 15.