PMID- 30584289
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20220330
IS  - 1178-1998 (Electronic)
IS  - 1176-9092 (Print)
IS  - 1176-9092 (Linking)
VI  - 13
DP  - 2018
TI  - Age and recurrent stroke are related to the severity of white matter 
      hyperintensities in lacunar infarction patients with diabetes.
PG  - 2487-2494
LID - 10.2147/CIA.S184463 [doi]
AB  - BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) is identified as a 
      marker of cerebral small vessel diseases and is a major contributor to cognitive 
      impairment, depression, gait disturbance, and urinary incontinence. However, the 
      risk factors for WMH in patients with type 2 diabetes mellitus (T2DM) has not 
      been well explored. Thus, in this study, we aimed to investigate the relationship 
      between the severity of WMH and vascular risk factors in lacunar infarction 
      patients with T2DM. METHODS: Consecutive lacunar infarction patients with T2DM 
      were recruited in this cross-sectional study. Paraventricular WMH (P-WMH) and 
      deep WMH (D-WMH) were separately scored by the Fazekas scale, and classified into 
      two categories by the severity. Vascular risk factors and clinical features were 
      compared between the mild and severe WMH. Multiple logistic regression analysis 
      was used to determine the relationship between severity of WMH and vascular risk 
      factors. RESULTS: A total of 327 participants aged 34-91 years were enrolled in 
      this study. Compared with the patients with mild P-WMH, the patients with severe 
      P-WMH had higher age (P=0.031), higher proportion of hypertension (P=0.042) and 
      stroke (P<0.001). Levels of TG, LDL, and HbA1c were significantly higher in 
      patients with mild P-WMH. Compared with the patients with mild D-WMH the patients 
      with severe D-WMH had higher age and hyperhomocysteinemia (HCY) level (P<0.001), 
      higher proportion of hyperlipidemia (P=0.008), and stroke (P<0.001). 
      Multivariable logistic regression analyses showed that higher age and recurrent 
      stroke were independently related to severe P-WMH and D-WMH in lacunar infarction 
      patients with T2DM. CONCLUSIONS: Age and recurrent stroke are related to the 
      severity of P-WMH and D-WMH in lacunar infarction patients with T2DM.
FAU - Yu, Ling
AU  - Yu L
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China, gaoshanmw@163.com.
FAU - Yang, Lei
AU  - Yang L
AD  - Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, People's Republic of China, huwenli@sina.com.
FAU - Zhang, Xiaoyu
AU  - Zhang X
AD  - Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, People's Republic of China, huwenli@sina.com.
FAU - Yuan, Junliang
AU  - Yuan J
AD  - Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, People's Republic of China, huwenli@sina.com.
FAU - Li, Yue
AU  - Li Y
AD  - Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, People's Republic of China, huwenli@sina.com.
FAU - Yang, Shuna
AU  - Yang S
AD  - Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, People's Republic of China, huwenli@sina.com.
FAU - Gu, Hua
AU  - Gu H
AD  - Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, People's Republic of China, huwenli@sina.com.
FAU - Hu, Wenli
AU  - Hu W
AD  - Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, People's Republic of China, huwenli@sina.com.
FAU - Gao, Shan
AU  - Gao S
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China, gaoshanmw@163.com.
LA  - eng
PT  - Journal Article
DEP - 20181207
PL  - New Zealand
TA  - Clin Interv Aging
JT  - Clinical interventions in aging
JID - 101273480
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/epidemiology
MH  - Hyperlipidemias/epidemiology
MH  - Hypertension/epidemiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Risk Factors
MH  - Stroke, Lacunar/*diagnostic imaging/*epidemiology
MH  - White Matter/*diagnostic imaging
PMC - PMC6290865
OTO - NOTNLM
OT  - lacunar infarction
OT  - leukoaraiosis
OT  - type 2 diabetes mellitus
OT  - white matter hyperintensities
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2018/12/26 06:00
MHDA- 2019/02/12 06:00
PMCR- 2018/12/07
CRDT- 2018/12/26 06:00
PHST- 2018/12/26 06:00 [entrez]
PHST- 2018/12/26 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2018/12/07 00:00 [pmc-release]
AID - cia-13-2487 [pii]
AID - 10.2147/CIA.S184463 [doi]
PST - epublish
SO  - Clin Interv Aging. 2018 Dec 7;13:2487-2494. doi: 10.2147/CIA.S184463. eCollection 
      2018.