PMID- 30584465
OWN - NLM
STAT- MEDLINE
DCOM- 20190122
LR  - 20200225
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2018
DP  - 2018
TI  - Interleukin-4 Boosts Insulin-Induced Energy Deposits by Enhancing Glucose Uptake 
      and Lipogenesis in Hepatocytes.
PG  - 6923187
LID - 10.1155/2018/6923187 [doi]
LID - 6923187
AB  - Type 2 diabetes mellitus (T2DM), with dysregulated hepatic gluconeogenesis as the 
      major cause of fasting hyperglycemia, is closely associated with chronic 
      inflammation. We previously demonstrated interleukin-4 (IL-4) improves insulin 
      sensitivity and glucose tolerance while reducing lipid deposits. The present 
      study examined the in vitro effects of IL-4 on insulin signaling molecules, 
      glucose uptake, and lipid metabolism in hepatocytes, as well as in vivo effects 
      on hepatic adiposity, for elucidating the roles of IL-4 in hepatic energy 
      metabolism. Potential interaction between IL-4 and insulin in regulating hepatic 
      metabolism was also investigated. Our results showed that IL-4 enhanced Akt and 
      GSK-3alpha/beta phosphorylations, which in turn promoted glycogen synthesis. IL-4 not 
      only potentiated basal glucose uptake by upregulating glucose transporter 2 
      expression but also promoted insulin-induced glucose uptake. Additionally, IL-4 
      increased triglyceride contents through facilitating free fatty acid uptake and 
      expression/activity of lipogenic enzymes. The major effects of IL-4 on the liver 
      were to promote energy storage by boosting insulin-stimulated glucose uptake and 
      lipid synthesis. This study provides evidence to implicate the novel roles of 
      IL-4 in mediating hepatic glucose and lipid metabolism, interactions between 
      immune responses and metabolic homeostasis, and the involvement of IL-4 in 
      metabolic abnormalities.
FAU - Yang, Ching-Ping
AU  - Yang CP
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung, 
      Taiwan.
FAU - Shiau, Ming-Yuh
AU  - Shiau MY
AD  - Department of Nursing, College of Nursing, Hungkuang University, Taichung, 
      Taiwan.
FAU - Lai, Yi-Ren
AU  - Lai YR
AD  - Department of Biotechnology and Laboratory Science in Medicine, National 
      Yang-Ming University, Taipei, Taiwan.
FAU - Ho, Kuo-Ting
AU  - Ho KT
AUID- ORCID: 0000-0001-7224-1338
AD  - Department of Biotechnology and Laboratory Science in Medicine, National 
      Yang-Ming University, Taipei, Taiwan.
FAU - Hsiao, Chiao-Wan
AU  - Hsiao CW
AD  - Department of Biotechnology and Laboratory Science in Medicine, National 
      Yang-Ming University, Taipei, Taiwan.
AD  - Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, 
      Taiwan.
FAU - Chen, Chun-Jung
AU  - Chen CJ
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung, 
      Taiwan.
FAU - Lo, Yu-Li
AU  - Lo YL
AD  - Department and Institute of Pharmacology, National Yang-Ming University, Taipei, 
      Taiwan.
FAU - Chang, Yih-Hsin
AU  - Chang YH
AUID- ORCID: 0000-0002-8262-6589
AD  - Department of Biotechnology and Laboratory Science in Medicine, National 
      Yang-Ming University, Taipei, Taiwan.
AD  - Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20181121
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 207137-56-2 (Interleukin-4)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Glucose/*metabolism
MH  - Hep G2 Cells
MH  - Hepatocytes/*drug effects/*metabolism
MH  - Humans
MH  - Insulin/*pharmacology
MH  - Interleukin-4/*pharmacology
MH  - Lipid Metabolism/*drug effects
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Signal Transduction/drug effects
MH  - Triglycerides/metabolism
PMC - PMC6280305
EDAT- 2018/12/26 06:00
MHDA- 2019/01/23 06:00
PMCR- 2018/11/21
CRDT- 2018/12/26 06:00
PHST- 2018/05/20 00:00 [received]
PHST- 2018/08/14 00:00 [revised]
PHST- 2018/09/06 00:00 [accepted]
PHST- 2018/12/26 06:00 [entrez]
PHST- 2018/12/26 06:00 [pubmed]
PHST- 2019/01/23 06:00 [medline]
PHST- 2018/11/21 00:00 [pmc-release]
AID - 10.1155/2018/6923187 [doi]
PST - epublish
SO  - Oxid Med Cell Longev. 2018 Nov 21;2018:6923187. doi: 10.1155/2018/6923187. 
      eCollection 2018.