PMID- 30584986
OWN - NLM
STAT- MEDLINE
DCOM- 20190613
LR  - 20211204
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 111
DP  - 2019 Mar
TI  - Knockdown of inhibitor of differentiation 1 suppresses proliferation and induces 
      apoptosis by inactivating PI3K/Akt/mTOR signaling in hemangioma-derived 
      endothelial cells.
PG  - 236-243
LID - S0753-3322(18)33443-7 [pii]
LID - 10.1016/j.biopha.2018.12.072 [doi]
AB  - Hemangioma (HA) is one of the commonest benign vascular neoplasms of infancy. 
      Inhibitor of differentiation 1 (ID-1) has been reported to be an oncogene in 
      multiple cancers. However, the role of ID-1 and its molecular mechanism in HA 
      progression have not been elucidated. In the present study, we found that ID-1 
      expression at mRNA and protein levels was up-regulated in HA-derived endothelial 
      cells (HDECs). Knockdown of ID-1 inhibited proliferation, facilitated apoptosis, 
      and enhanced propranolol cytotoxicity in HDECs. Knockdown of ID-1 decreased the 
      protein levels of phospholyrated protein kinase-B (Akt) and phospholyrated 
      mammalian target of rapamycin (mTOR). Inhibition of PI3K/Akt/mTOR pathway by 
      LY294002 abrogated ID-1-mediated pro-proliferation and anti-apoptosis effects in 
      HDECs. In conclusion, knockdown of ID-1 suppressed proliferation and promoted 
      apoptosis by inactivating phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR signaling 
      in HDECs, shedding light on the function of ID-1 in HA progression and 
      highlighting the therapeutic value of ID-1 for HA.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Sun, Bin
AU  - Sun B
AD  - Department of Hemangioma and Vascular Malformation, Henan Provincial People's 
      Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, China.
FAU - Dong, Changxian
AU  - Dong C
AD  - Department of Hemangioma and Vascular Malformation, Henan Provincial People's 
      Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, China. 
      Electronic address: zzchangxiandong@126.com.
FAU - Lei, Hongzhao
AU  - Lei H
AD  - Department of Hemangioma and Vascular Malformation, Henan Provincial People's 
      Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, China.
FAU - Gong, Yubin
AU  - Gong Y
AD  - Department of Hemangioma and Vascular Malformation, Henan Provincial People's 
      Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, China.
FAU - Li, Miaomiao
AU  - Li M
AD  - Department of Hemangioma and Vascular Malformation, Henan Provincial People's 
      Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, China.
FAU - Zhang, Yuanfang
AU  - Zhang Y
AD  - Department of Hemangioma and Vascular Malformation, Henan Provincial People's 
      Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, China.
FAU - Zhang, Hongyu
AU  - Zhang H
AD  - Department of Hemangioma and Vascular Malformation, Henan Provincial People's 
      Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, China.
FAU - Sun, Longlong
AU  - Sun L
AD  - School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
LA  - eng
PT  - Journal Article
DEP - 20181222
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Inhibitor of Differentiation Protein 1)
RN  - 0 (Phosphoinositide-3 Kinase Inhibitors)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.1.137 (Phosphatidylinositol 3-Kinase)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Apoptosis/physiology
MH  - Cell Proliferation/*physiology
MH  - Endothelial Cells/metabolism
MH  - Gene Knockdown Techniques/methods
MH  - Hemangioma/*metabolism/prevention & control
MH  - Human Umbilical Vein Endothelial Cells/metabolism
MH  - Humans
MH  - Inhibitor of Differentiation Protein 1/*deficiency/genetics
MH  - Phosphatidylinositol 3-Kinase/*metabolism
MH  - Phosphoinositide-3 Kinase Inhibitors
MH  - Proto-Oncogene Proteins c-akt/antagonists & inhibitors/*metabolism
MH  - Signal Transduction/physiology
MH  - TOR Serine-Threonine Kinases/antagonists & inhibitors/*metabolism
OTO - NOTNLM
OT  - Apoptosis
OT  - Hemangioma
OT  - ID-1
OT  - PI3K/Akt/mTOR
OT  - Proliferation
EDAT- 2018/12/26 06:00
MHDA- 2019/06/14 06:00
CRDT- 2018/12/26 06:00
PHST- 2018/05/24 00:00 [received]
PHST- 2018/12/13 00:00 [revised]
PHST- 2018/12/17 00:00 [accepted]
PHST- 2018/12/26 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/12/26 06:00 [entrez]
AID - S0753-3322(18)33443-7 [pii]
AID - 10.1016/j.biopha.2018.12.072 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2019 Mar;111:236-243. doi: 10.1016/j.biopha.2018.12.072. 
      Epub 2018 Dec 22.