PMID- 30588470
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2287-979X (Print)
IS  - 2288-0011 (Electronic)
IS  - 2287-979X (Linking)
VI  - 53
IP  - 4
DP  - 2018 Dec
TI  - Altered expression of MALAT1 lncRNA in chronic lymphocytic leukemia patients, 
      correlation with cytogenetic findings.
PG  - 320-324
LID - 10.5045/br.2018.53.4.320 [doi]
AB  - BACKGROUND: Recent studies have devoted much attention to non-protein-coding 
      transcripts in relation to a wide range of malignancies. MALAT1, a long 
      non-coding RNA, has been reported to be associated with cancer progression and 
      prognosis. Thus, we here determined MALAT1 gene expression in chronic lymphocytic 
      leukemia (CLL), a genetically heterogeneous disease, and explored its possible 
      relationships with cytogenetic abnormalities. METHODS: MALAT1 expression level 
      was evaluated using real-time quantitative reverse transcription polymerase chain 
      reaction (qRT-PCR) on blood mononuclear cells from 30 non-treated CLL patients 
      and 30 matched healthy controls. Cytogenetic abnormalities were determined in 
      patients by fluorescence in situ hybridization (FISH). RESULTS: MALAT1 expression 
      level was up-regulated in the CLL group compared to healthy controls (P=0.008). 
      Del13q14, followed by Del11q22, were the most prevalent cytogenetic 
      abnormalities. We found no association between the FISH results and MALAT1 
      expression in patients. CONCLUSION: Altered expression of MALAT1 is associated 
      with CLL development. Further investigations are required to assess the 
      relationship between this long non-coding RNA and CLL patient survival and 
      prognosis.
FAU - Ahmadi, Abdolrahim
AU  - Ahmadi A
AD  - Department of Hematology, Faculty of Medical Sciences, Tarbiat Modarres 
      University, Tehran, Iran.
FAU - Kaviani, Saeid
AU  - Kaviani S
AD  - Department of Hematology, Faculty of Medical Sciences, Tarbiat Modarres 
      University, Tehran, Iran.
FAU - Yaghmaie, Marjan
AU  - Yaghmaie M
AD  - Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran, Iran.
AD  - Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran, 
      Iran.
AD  - Hematologic Malignancies Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Pashaiefar, Hossein
AU  - Pashaiefar H
AD  - Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran, Iran.
AD  - Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran, 
      Iran.
AD  - Hematologic Malignancies Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Ahmadvand, Mohammad
AU  - Ahmadvand M
AD  - Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran, Iran.
AD  - Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran, 
      Iran.
AD  - Hematologic Malignancies Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Jalili, Mahdi
AU  - Jalili M
AD  - Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran, Iran.
AD  - Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran, 
      Iran.
AD  - Hematologic Malignancies Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Alimoghaddam, Kamran
AU  - Alimoghaddam K
AD  - Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran, Iran.
AD  - Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran, 
      Iran.
AD  - Hematologic Malignancies Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Eslamijouybari, Mohammad
AU  - Eslamijouybari M
AD  - Comprehensive Cancer Research Center, Mazandaran University of Medical Science, 
      Sari, Iran.
FAU - Ghavamzadeh, Ardeshir
AU  - Ghavamzadeh A
AD  - Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran, Iran.
AD  - Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran, 
      Iran.
AD  - Hematologic Malignancies Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20181217
PL  - Switzerland
TA  - Blood Res
JT  - Blood research
JID - 101605247
PMC - PMC6300670
OTO - NOTNLM
OT  - Chronic lymphocytic leukemia
OT  - FISH
OT  - MALAT1
OT  - qRT-PCR
COIS- Authors' Disclosures of Potential Conflicts of Interest: No potential conflicts 
      of interest relevant to this article were reported.
EDAT- 2018/12/28 06:00
MHDA- 2018/12/28 06:01
PMCR- 2018/12/01
CRDT- 2018/12/28 06:00
PHST- 2018/06/07 00:00 [received]
PHST- 2018/08/27 00:00 [revised]
PHST- 2018/09/05 00:00 [accepted]
PHST- 2018/12/28 06:00 [entrez]
PHST- 2018/12/28 06:00 [pubmed]
PHST- 2018/12/28 06:01 [medline]
PHST- 2018/12/01 00:00 [pmc-release]
AID - 10.5045/br.2018.53.4.320 [doi]
PST - ppublish
SO  - Blood Res. 2018 Dec;53(4):320-324. doi: 10.5045/br.2018.53.4.320. Epub 2018 Dec 
      17.