PMID- 30588521
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2508-5859 (Electronic)
IS  - 2508-5778 (Print)
IS  - 2508-5859 (Linking)
VI  - 22
IP  - 4
DP  - 2018 Nov
TI  - A composite of urinary biomarkers for differentiating between tubulointerstitial 
      inflammation and interstitial fibrosis/tubular atrophy in kidney allografts.
PG  - 310-320
LID - 10.14701/ahbps.2018.22.4.310 [doi]
AB  - BACKGROUNDS/AIMS: Compared with a single urinary biomarker, a composite of 
      multiple urinary biomarkers may be more helpful for differentiating 
      tubulointerstitial inflammation from interstitial fibrosis/tubular atrophy (IFTA) 
      in kidney allografts. METHODS: In this cross-sectional cohort study, we collected 
      urine samples from 115 patients with for-cause biopsy, 53 patients with stable 
      allografts, and 50 living kidney donors. We measured the urinary levels of 
      transglutaminase 2 (TG2), syndecan-4 (SDC4), alpha 1 microglobulin (A1M), 
      interferon-inducible protein 10 (IP-10), interleukin 6 (IL-6), and monocyte 
      chemoattractant protein-1 (MCP-1). RESULTS: The for-cause biopsy group showed 
      significantly higher levels of log(e)TG2/Cr, log(e)A1M/Cr, log(e)IL-6/Cr, and 
      log(e)MCP-1/Cr compared with other groups. In the for-cause biopsy group, 
      log(e)TG2/Cr level was positively correlated with the severity of IFTA. After 
      adjusting for age, sex, body mass index, diabetes, hypertension, cardiovascular 
      disease, and the interval between kidney transplant and biopsy, TG2 and the 
      interval between transplant and biopsy were significantly correlated variables 
      for the severity of IFTA. Regarding tubulointerstitial inflammation, Body mass 
      index, TG2, SDC4, and IP-10 were positively-correlated variables, and MCP-1 and 
      the interval between transplant and biopsy were negatively-correlated variables. 
      CONCLUSIONS: Our results show that post-transplant urinary levels of TG2, SDC4, 
      MCP-1 and IP-10 may be a useful biomarker for tubulointerstitial inflammation and 
      IFTA.
FAU - Wee, Yu-Mee
AU  - Wee YM
AD  - Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan 
      College of Medicine, Seoul, Korea.
FAU - Lee, Hae-Won
AU  - Lee HW
AD  - Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan 
      Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
FAU - Choi, Monica Young
AU  - Choi MY
AD  - Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan 
      College of Medicine, Seoul, Korea.
FAU - Jung, Hey Rim
AU  - Jung HR
AD  - Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan 
      College of Medicine, Seoul, Korea.
FAU - Choi, Ji Yoon
AU  - Choi JY
AD  - Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan 
      Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
FAU - Kwon, Hyun Wook
AU  - Kwon HW
AD  - Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan 
      Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
FAU - Jung, Joo Hee
AU  - Jung JH
AD  - Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan 
      Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
FAU - Kim, Young Hoon
AU  - Kim YH
AD  - Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan 
      Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
FAU - Han, Duck Jong
AU  - Han DJ
AD  - Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan 
      Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
FAU - Shin, Sung
AU  - Shin S
AD  - Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan 
      College of Medicine, Seoul, Korea.
AD  - Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan 
      Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20181127
PL  - Korea (South)
TA  - Ann Hepatobiliary Pancreat Surg
JT  - Annals of hepato-biliary-pancreatic surgery
JID - 101698342
PMC - PMC6295379
OTO - NOTNLM
OT  - Allograft
OT  - Biologic markers
OT  - Interstitial
OT  - Nephritis
EDAT- 2018/12/28 06:00
MHDA- 2018/12/28 06:01
PMCR- 2018/11/01
CRDT- 2018/12/28 06:00
PHST- 2018/10/14 00:00 [received]
PHST- 2018/10/20 00:00 [revised]
PHST- 2018/10/20 00:00 [accepted]
PHST- 2018/12/28 06:00 [entrez]
PHST- 2018/12/28 06:00 [pubmed]
PHST- 2018/12/28 06:01 [medline]
PHST- 2018/11/01 00:00 [pmc-release]
AID - 10.14701/ahbps.2018.22.4.310 [doi]
PST - ppublish
SO  - Ann Hepatobiliary Pancreat Surg. 2018 Nov;22(4):310-320. doi: 
      10.14701/ahbps.2018.22.4.310. Epub 2018 Nov 27.