PMID- 30588714
OWN - NLM
STAT- MEDLINE
DCOM- 20200601
LR  - 20231012
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Print)
IS  - 1050-9631 (Linking)
VI  - 29
IP  - 7
DP  - 2019 Jul
TI  - Associative memory for conceptually unitized word pairs in mild cognitive 
      impairment is related to the volume of the perirhinal cortex.
PG  - 630-638
LID - 10.1002/hipo.23063 [doi]
AB  - Unitization, that is, the encoding of an association as one integrated entity, 
      has been shown to improve associative memory in populations presenting with 
      associative memory deficit due to hippocampal dysfunction, such as amnesic 
      patients with focal hippocampal lesions and healthy older adults. One reason for 
      this benefit is that encoding of unitized associations would rely on the 
      perirhinal cortex (PrC) and thus minimize the need for hippocampal recruitment. 
      Mild cognitive impairment (MCI) is accompanied by a deficit in associative 
      memory. However, unitization has never been studied to explore the potential 
      benefit in associative memory in MCI, maybe because MCI is characterized by PrC 
      pathology. However, the PrC may potentially still function sufficiently to allow 
      for the successful adoption of unitization. In this study, we aimed at assessing 
      whether unitization could attenuate MCI patients' associative memory deficit, and 
      whether the ability to remember unitized associations would be modulated by the 
      integrity of the PrC in MCI patients. Unitization was manipulated at a conceptual 
      level, by encouraging participants to encode unrelated word pairs as new compound 
      words. Participants also underwent a structural MRI exam, and measures of PrC 
      were extracted (Brodmann Areas [BA] 35 and 36). Results showed that, contrary to 
      healthy controls, MCI patients did not benefit from unitization. Moreover, their 
      memory performance for unitized associations was related to the measure of PrC 
      integrity (BA35), while it was not the case in controls. This finding thus 
      suggests that unitization does not help to attenuate the associative deficit in 
      MCI patients, and brings support to the literature linking unitization to the PrC 
      function.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Delhaye, Emma
AU  - Delhaye E
AUID- ORCID: 0000-0001-9224-267X
AD  - GIGA-CRC In-Vivo Imaging, Liege University, Liege, Belgium.
AD  - PsyNCog, Faculty of Psychology, Liege, Belgium.
FAU - Mechanic-Hamilton, Dawn
AU  - Mechanic-Hamilton D
AD  - Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
AD  - Penn Memory Center, University of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Saad, Laura
AU  - Saad L
AD  - Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
AD  - Penn Memory Center, University of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Das, Sandhitsu R
AU  - Das SR
AD  - Penn Image Computing and Science Laboratory, Department of Radiology, University 
      of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Wisse, Laura E M
AU  - Wisse LEM
AD  - Penn Memory Center, University of Pennsylvania, Philadelphia, Pennsylvania.
AD  - Penn Image Computing and Science Laboratory, Department of Radiology, University 
      of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Yushkevich, Paul A
AU  - Yushkevich PA
AD  - Penn Image Computing and Science Laboratory, Department of Radiology, University 
      of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Wolk, David A
AU  - Wolk DA
AD  - Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
AD  - Penn Memory Center, University of Pennsylvania, Philadelphia, Pennsylvania.
AD  - Penn Image Computing and Science Laboratory, Department of Radiology, University 
      of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Bastin, Christine
AU  - Bastin C
AD  - GIGA-CRC In-Vivo Imaging, Liege University, Liege, Belgium.
AD  - PsyNCog, Faculty of Psychology, Liege, Belgium.
LA  - eng
GR  - P30 AG010124/AG/NIA NIH HHS/United States
GR  - S#14003/Alzheimer Research Foundation (SAO-FRA)/International
GR  - Leon Fredericq Foundation/International
GR  - French-speaking Community of Belgium/International
GR  - 2016-NIRG-394141/Alzheimer Association/International
GR  - R01 AG056014/AG/NIA NIH HHS/United States
GR  - University of Liege/International
GR  - #FSRC-14/11/Wallonia Brussels Federation Special Funds for Research/International
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20181226
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Association Learning/*physiology
MH  - Case-Control Studies
MH  - Cognitive Dysfunction/*diagnostic imaging/*psychology
MH  - Female
MH  - Functional Neuroimaging
MH  - Hippocampus/diagnostic imaging/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory/*physiology
MH  - Perirhinal Cortex/*diagnostic imaging/physiopathology
PMC - PMC6565465
MID - NIHMS1017625
OTO - NOTNLM
OT  - associative memory
OT  - episodic memory
OT  - mild cognitive impairment
OT  - perirhinal cortex
OT  - unitization
EDAT- 2018/12/28 06:00
MHDA- 2020/06/02 06:00
PMCR- 2019/07/01
CRDT- 2018/12/28 06:00
PHST- 2018/06/07 00:00 [received]
PHST- 2018/11/23 00:00 [revised]
PHST- 2018/11/30 00:00 [accepted]
PHST- 2018/12/28 06:00 [pubmed]
PHST- 2020/06/02 06:00 [medline]
PHST- 2018/12/28 06:00 [entrez]
PHST- 2019/07/01 00:00 [pmc-release]
AID - 10.1002/hipo.23063 [doi]
PST - ppublish
SO  - Hippocampus. 2019 Jul;29(7):630-638. doi: 10.1002/hipo.23063. Epub 2018 Dec 26.