PMID- 30588862
OWN - NLM
STAT- MEDLINE
DCOM- 20190902
LR  - 20190902
IS  - 1537-6524 (Electronic)
IS  - 1537-6516 (Linking)
VI  - 29
IP  - 5
DP  - 2019 Jun
TI  - Neuromodulatory potential of phenylpropanoids; para-methoxycinnamic acid and 
      ethyl-p-methoxycinnamate on aluminum-induced memory deficit in rats.
PG  - 334-343
LID - 10.1080/15376516.2018.1561779 [doi]
AB  - Para-methoxycinnamic acid (PMCA) and Ethyl-p-methoxycinnamate (EPMC) are reported 
      to possess neuroprotective effect in reversing an acute memory deficit. However, 
      there is a dearth of evidence for their therapeutic effect in chronic memory 
      deficit. Thus, there is a scope to study these derivatives against the chronic 
      model of cognitive dysfunction. The present study was aimed to determine the 
      cognitive enhancing activity of PMCA and EPMC in aluminum-induced chronic 
      dementia. Cognitive enhancing property of PMCA and EPMC was assessed using Morris 
      water maze by analyzing spatial memory parameters such as escape latency, 
      D-quadrant latency, and island entries. To find a possible mechanism, the effect 
      of test compounds on altered acetylcholinesterase (AChE) activity and oxidative 
      stress was determined in the hippocampus and frontal cortex of rats. Docking 
      interaction of these derivatives with acetylcholinesterase enzyme and glutamate 
      receptors was also studied. Treatment with PMCA and EPMC showed a significant 
      improvement in spatial memory markers and altered hippocampal AChE activity in 
      rats with cognitive dysfunction. The implication of hippocampal and cortical 
      oxidative stress in memory impairment was confirmed with decreased 
      catalase/increased thiobarbituric acid reactive substances (TBARS) in rats. PMCA 
      and EPMC reversed the oxidative stress in the brain by negatively affecting TBARS 
      levels. Against depleted catalase levels, PMCA was more effective than EPMC in 
      raising the depleted catalase levels. In silico analysis revealed poor affinity 
      of EPMC and PMCA with AChE enzyme and glutamate receptor. To conclude, PMCA and 
      EPMC exerted cognitive enhancing property independent of direct AChE and 
      glutamate receptor inhibition.
FAU - Rijal, Samita
AU  - Rijal S
AD  - a Department of Pharmacology, Manipal College of Pharmaceutical Sciences , 
      Manipal Academy of Higher Education , Manipal , India.
FAU - Changdar, Nilanjan
AU  - Changdar N
AD  - a Department of Pharmacology, Manipal College of Pharmaceutical Sciences , 
      Manipal Academy of Higher Education , Manipal , India.
FAU - Kinra, Manas
AU  - Kinra M
AD  - a Department of Pharmacology, Manipal College of Pharmaceutical Sciences , 
      Manipal Academy of Higher Education , Manipal , India.
FAU - Kumar, Ayush
AU  - Kumar A
AD  - a Department of Pharmacology, Manipal College of Pharmaceutical Sciences , 
      Manipal Academy of Higher Education , Manipal , India.
FAU - Nampoothiri, Madhavan
AU  - Nampoothiri M
AD  - a Department of Pharmacology, Manipal College of Pharmaceutical Sciences , 
      Manipal Academy of Higher Education , Manipal , India.
FAU - Arora, Devinder
AU  - Arora D
AD  - b School of Pharmacy and Pharmacology , QUM, MHIQ, Griffith University , 
      Queensland , Australia.
FAU - Shenoy, Rekha R
AU  - Shenoy RR
AD  - a Department of Pharmacology, Manipal College of Pharmaceutical Sciences , 
      Manipal Academy of Higher Education , Manipal , India.
FAU - Ranganath Pai, K Sreedhara
AU  - Ranganath Pai KS
AUID- ORCID: 0000-0002-2017-9533
AD  - a Department of Pharmacology, Manipal College of Pharmaceutical Sciences , 
      Manipal Academy of Higher Education , Manipal , India.
FAU - Joseph, Alex
AU  - Joseph A
AD  - c Department of Pharmaceutical Chemistry , Manipal College of Pharmaceutical 
      Sciences, Manipal Academy of Higher Education , Manipal , India.
FAU - Mudgal, Jayesh
AU  - Mudgal J
AUID- ORCID: 0000-0001-8190-7031
AD  - a Department of Pharmacology, Manipal College of Pharmaceutical Sciences , 
      Manipal Academy of Higher Education , Manipal , India.
LA  - eng
PT  - Journal Article
DEP - 20190204
PL  - England
TA  - Toxicol Mech Methods
JT  - Toxicology mechanisms and methods
JID - 101134521
RN  - 0 (Cinnamates)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (ethyl 4-methoxycinnamate)
RN  - 6G4ML8401A (4-methoxycinnamic acid)
RN  - CPD4NFA903 (Aluminum)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
SB  - IM
MH  - Acetylcholinesterase/metabolism
MH  - Aluminum/*toxicity
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Behavior, Animal/drug effects
MH  - Cinnamates/*pharmacology
MH  - Frontal Lobe/drug effects/enzymology
MH  - Hippocampus/drug effects/enzymology
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/chemically induced/*prevention & control
MH  - Molecular Docking Simulation
MH  - Neuroprotective Agents/*pharmacology
MH  - Oxidative Stress/drug effects
MH  - Rats, Wistar
MH  - Spatial Memory/drug effects
OTO - NOTNLM
OT  - -methoxycinnamic acid
OT  - Acetylcholinesterase
OT  - dementia
OT  - docking
OT  - ethyl--methoxycinnamate
EDAT- 2018/12/28 06:00
MHDA- 2019/09/03 06:00
CRDT- 2018/12/28 06:00
PHST- 2018/12/28 06:00 [pubmed]
PHST- 2019/09/03 06:00 [medline]
PHST- 2018/12/28 06:00 [entrez]
AID - 10.1080/15376516.2018.1561779 [doi]
PST - ppublish
SO  - Toxicol Mech Methods. 2019 Jun;29(5):334-343. doi: 10.1080/15376516.2018.1561779. 
      Epub 2019 Feb 4.