PMID- 30589871
OWN - NLM
STAT- MEDLINE
DCOM- 20190514
LR  - 20200309
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 12
DP  - 2018
TI  - Cardiovascular sexual dimorphism in a diet-induced type 2 diabetes rodent model, 
      the Nile rat (Arvicanthis niloticus).
PG  - e0208987
LID - 10.1371/journal.pone.0208987 [doi]
LID - e0208987
AB  - BACKGROUND: The Nile rat (Arvicanthis niloticus) is an emerging laboratory model 
      of type 2 diabetes. When fed standard rodent chow, the majority of males progress 
      from hyperinsulinemia by 2 months to hyperglycemia by 6 months, while most 
      females remain at the hyperinsulinemia-only stage (prediabetic) from 2 months 
      onward. Since diabetic cardiomyopathy is the major cause of type-2 diabetes 
      mellitus (T2DM)-related mortality, we examined whether sexual dimorphism might 
      entail cardiac functional changes. Our ultimate goal was to isolate the effect of 
      diet as a modifiable lifestyle factor. MATERIALS AND METHODS: Nile rats were fed 
      either standard rodent chow (Chow group) or a high-fiber diet previously 
      established to prevent type 2 diabetes (Fiber group). Cardiac function was 
      determined with echocardiography at 12 months of age. To isolate the effect of 
      diet alone, only the small subset of animals resistant to both hyperinsulinemia 
      and hyperglycemia were included in this study. RESULTS: In males, Chow (compared 
      to Fiber) was associated with elevated heart rate and mitral E/A velocity ratio, 
      and with lower e'-wave velocity, isovolumetric relaxation time, and ejection 
      time. Of note, these clinically atypical types of diastolic dysfunction occurred 
      independently of body weight. In contrast, females did not exhibit changes in 
      cardiovascular function between diets. CONCLUSIONS: The higher prevalence of T2DM 
      in males correlates with their susceptibility to develop subtle diastolic cardiac 
      dysfunction when fed a Western style diet (throughout most of their lifespan) 
      despite no systemic evidence of metabolic syndrome, let alone T2DM.
FAU - Schneider, Jillian
AU  - Schneider J
AD  - Department of Physiology, University of Alberta, Edmonton, AB, Canada.
FAU - Kuny, Sharee
AU  - Kuny S
AD  - Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, 
      AB, Canada.
FAU - Beker, Donna
AU  - Beker D
AD  - Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
FAU - Sauve, Yves
AU  - Sauve Y
AD  - Department of Physiology, University of Alberta, Edmonton, AB, Canada.
AD  - Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, 
      AB, Canada.
FAU - Lemieux, Helene
AU  - Lemieux H
AUID- ORCID: 0000-0002-8864-6062
AD  - Faculty Saint-Jean, Women and Children's Health Research Institute, Dept. of 
      Medicine, University of Alberta, Edmonton, AB, Canada.
LA  - eng
GR  - MOP 125873/Canadian Institutes of Health/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181227
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Fiber)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Body Weight
MH  - Diabetes Mellitus, Type 2/*pathology
MH  - *Diet
MH  - Dietary Fiber
MH  - Disease Models, Animal
MH  - Female
MH  - Heart Rate
MH  - Heart Ventricles/chemistry/pathology
MH  - Male
MH  - Rats
MH  - Sex Characteristics
MH  - Ventricular Function, Left/physiology
PMC - PMC6307866
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/12/28 06:00
MHDA- 2019/05/15 06:00
PMCR- 2018/12/27
CRDT- 2018/12/28 06:00
PHST- 2018/08/28 00:00 [received]
PHST- 2018/11/28 00:00 [accepted]
PHST- 2018/12/28 06:00 [entrez]
PHST- 2018/12/28 06:00 [pubmed]
PHST- 2019/05/15 06:00 [medline]
PHST- 2018/12/27 00:00 [pmc-release]
AID - PONE-D-18-25291 [pii]
AID - 10.1371/journal.pone.0208987 [doi]
PST - epublish
SO  - PLoS One. 2018 Dec 27;13(12):e0208987. doi: 10.1371/journal.pone.0208987. 
      eCollection 2018.