PMID- 30590063
OWN - NLM
STAT- MEDLINE
DCOM- 20191126
LR  - 20191126
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Linking)
VI  - 124
DP  - 2019 Feb 18
TI  - Similarities and differences in cerebellar grey matter volume and disrupted 
      functional connectivity in idiopathic Parkinson's disease and multiple system 
      atrophy.
PG  - 125-132
LID - S0028-3932(18)30783-8 [pii]
LID - 10.1016/j.neuropsychologia.2018.12.019 [doi]
AB  - OBJECTIVE: This study investigated the potential differences in changes to 
      cerebellar grey matter volume (GMV) and functional connectivity (FC) and the 
      association between them, which might elucidate cerebellar function in multiple 
      system atrophy (MSA) and idiopathic Parkinson's disease (IPD). METHODS: 
      Resting-state functional magnetic resonance imaging and three-dimensional T1 
      scans were obtained from 38 IPD, 62 MSA, and 59 healthy controls (HC). Seed-based 
      connectivity analysis and voxel-based morphometry analysis were performed to 
      assess the changes of cerebellar FC and GMV between the patient groups. RESULT: 
      Decreased cerebellar GMV was found in the motor cerebellum in both patient groups 
      relative to HC, and broader reduction of GMV was observed in both cognitive and 
      motor cerebellum in MSA compared with IPD and HC. Compared with IPD, the MSA 
      group exhibited decreased FC between bilateral dentate nucleus (DN) and default 
      mode network (DMN). Decreased intracerebellar FC was observed in both patient 
      groups relative to HC. Cerebellar GMV was positively correlated with FC of 
      intracerebellum and DN-DMN in MSA. Motor/cognitive scores were associated with 
      DN-DMN FC, with considerable cerebellar GMV loss in MSA patients. CONCLUSION: 
      Cerebellar GMV loss and cerebellar FC alterations showed similarities in IPD and 
      MSA, along with more widespread changes to GMV in motor and cognitive cerebellum 
      and altered DN-DMN FC in MSA. Further research is needed to better describe the 
      alterations of cerebellar GMV in the cognitive cerebellum and association between 
      cerebellar GMV and intracerebellar FC during the early stages of MSA and IPD.
CI  - Copyright (c) 2018. Published by Elsevier Ltd.
FAU - Wang, Na
AU  - Wang N
AD  - Huashan Hospital Fudan University, Department of Radiology, China. Electronic 
      address: wangna100medical@126.com.
FAU - Zhang, Liang
AU  - Zhang L
AD  - Fudan University Shanghai Cancer Center, Department of Interventional Radiology, 
      Shanghai, China. Electronic address: 270973226@163.com.
FAU - Yang, HuaGuang
AU  - Yang H
AD  - The First Affiliated Hospital of China Medical University, Department of 
      Radiology, China. Electronic address: yanghuaguang1@163.com.
FAU - Liu, Hu
AU  - Liu H
AD  - The First Affiliated Hospital of China Medical University, Department of 
      Radiology, China. Electronic address: liuhu1234567@126.com.
FAU - Luo, XiaoGuang
AU  - Luo X
AD  - The First Affiliated Hospital of China Medical University, Department of 
      Neurology, China. Electronic address: grace_shenyang@163.com.
FAU - Fan, GuoGuang
AU  - Fan G
AD  - The First Affiliated Hospital of China Medical University, Department of 
      Radiology, China. Electronic address: fanguog@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20181224
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
SB  - IM
MH  - Aged
MH  - Brain Mapping
MH  - Cerebellum/diagnostic imaging/*pathology/*physiopathology
MH  - Female
MH  - Gray Matter/diagnostic imaging/*physiology/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple System Atrophy/diagnostic imaging/*pathology/*physiopathology
MH  - Neural Pathways/diagnostic imaging/pathology/physiopathology
MH  - Parkinson Disease/diagnostic imaging/*pathology/*physiopathology
OTO - NOTNLM
OT  - Cerebellum
OT  - Dentate nucleus
OT  - Functional connectivity
OT  - Grey matter volume
EDAT- 2018/12/28 06:00
MHDA- 2019/11/27 06:00
CRDT- 2018/12/28 06:00
PHST- 2018/04/19 00:00 [received]
PHST- 2018/10/13 00:00 [revised]
PHST- 2018/12/21 00:00 [accepted]
PHST- 2018/12/28 06:00 [pubmed]
PHST- 2019/11/27 06:00 [medline]
PHST- 2018/12/28 06:00 [entrez]
AID - S0028-3932(18)30783-8 [pii]
AID - 10.1016/j.neuropsychologia.2018.12.019 [doi]
PST - ppublish
SO  - Neuropsychologia. 2019 Feb 18;124:125-132. doi: 
      10.1016/j.neuropsychologia.2018.12.019. Epub 2018 Dec 24.