PMID- 30590485
OWN - NLM
STAT- MEDLINE
DCOM- 20200803
LR  - 20200803
IS  - 1522-9645 (Electronic)
IS  - 0195-668X (Linking)
VI  - 40
IP  - 1
DP  - 2019 Jan 1
TI  - High blood pressure response to exercise predicts future development of 
      hypertension in young athletes.
PG  - 62-68
LID - 10.1093/eurheartj/ehy810 [doi]
AB  - AIMS: Due to superior exercise performance, athletes show higher blood pressure 
      (BP) at peak exercise compared to untrained individuals. Thus, higher reference 
      values for peak exercise systolic and diastolic BP were reported specifically for 
      athletes. However, the prognostic significance of high blood pressure response 
      (HBPR) to exercise has not yet been clarified in this population. METHODS AND 
      RESULTS: One hundred and forty-one normotensive athletes with HBPR to exercise 
      were compared to 141 normotensive athletes with normal blood pressure response 
      (NBPR) to exercise, matched for gender, age, body size, and type of sport. All 
      athletes were followed up for 6.5 +/- 2.8 years. Over follow-up, no cardiac events 
      occurred; 24 athletes were diagnosed essential hypertension (8.5%). Specifically, 
      19 (13.5%) belonged to the HBPR compared with 5 (3.5%) in the NBPR group 
      (P = 0.003). Kaplan-Meier analysis confirmed that the incidence of hypertension 
      during follow-up was higher in the HBPR group (log-rank chi2P-value = 0.009). 
      Multivariable analysis by Cox proportional hazard survival model showed that 
      resting BP and HBPR at baseline evaluation were the strongest predictors of 
      incident hypertension (chi2 for the model 30.099; P < 0.001). Specifically, HBPR 
      was associated with a hazard ratio of 3.6 (95% confidence interval 1.3-9.9) of 
      developing hypertension. Over follow-up exercise capacity, as well as morphologic 
      and functional cardiac parameters in athletes from both groups did not change 
      significantly. CONCLUSION: The present study showed that an exaggerated BP 
      response to exercise increased the risk for incident hypertension in highly 
      trained and normotensive athletes over a middle-term period.
FAU - Caselli, Stefano
AU  - Caselli S
AD  - Institute of Sports Medicine and Science, Rome, Largo Piero Gabrielli, Roma, 
      Italy.
AD  - Cardiovascular Center Zurich, Hirslanden Klinik im Park, Seestrasse 220, Zurich, 
      Switzerland.
FAU - Serdoz, Andrea
AU  - Serdoz A
AD  - Institute of Sports Medicine and Science, Rome, Largo Piero Gabrielli, Roma, 
      Italy.
FAU - Mango, Federica
AU  - Mango F
AD  - Institute of Sports Medicine and Science, Rome, Largo Piero Gabrielli, Roma, 
      Italy.
FAU - Lemme, Erika
AU  - Lemme E
AD  - Institute of Sports Medicine and Science, Rome, Largo Piero Gabrielli, Roma, 
      Italy.
FAU - Vaquer Segui, Antonia
AU  - Vaquer Segui A
AD  - Institute of Sports Medicine and Science, Rome, Largo Piero Gabrielli, Roma, 
      Italy.
FAU - Milan, Alberto
AU  - Milan A
AD  - Department of Medical Sciences, Hospital 'Citta della Salute e della Scienza di 
      Torino', University of Torino, Corso Bramante, 88, Torino, Italy.
FAU - Attenhofer Jost, Christine
AU  - Attenhofer Jost C
AD  - Cardiovascular Center Zurich, Hirslanden Klinik im Park, Seestrasse 220, Zurich, 
      Switzerland.
FAU - Schmied, Christian
AU  - Schmied C
AD  - University Heart Center, Ramistrasse 100, Zurich, Switzerland.
FAU - Spataro, Antonio
AU  - Spataro A
AD  - Institute of Sports Medicine and Science, Rome, Largo Piero Gabrielli, Roma, 
      Italy.
FAU - Pelliccia, Antonio
AU  - Pelliccia A
AD  - Institute of Sports Medicine and Science, Rome, Largo Piero Gabrielli, Roma, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
MH  - Adult
MH  - Blood Pressure/*physiology
MH  - Exercise/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypertension/*epidemiology
MH  - Male
MH  - Prognosis
MH  - Young Adult
EDAT- 2018/12/28 06:00
MHDA- 2020/08/04 06:00
CRDT- 2018/12/28 06:00
PHST- 2018/05/25 00:00 [received]
PHST- 2018/11/12 00:00 [accepted]
PHST- 2018/12/28 06:00 [pubmed]
PHST- 2020/08/04 06:00 [medline]
PHST- 2018/12/28 06:00 [entrez]
AID - 5255629 [pii]
AID - 10.1093/eurheartj/ehy810 [doi]
PST - ppublish
SO  - Eur Heart J. 2019 Jan 1;40(1):62-68. doi: 10.1093/eurheartj/ehy810.