PMID- 30591041
OWN - NLM
STAT- MEDLINE
DCOM- 20190111
LR  - 20220330
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 18
IP  - 1
DP  - 2018 Dec 27
TI  - Maoberry (Antidesma bunius) ameliorates oxidative stress and inflammation in 
      cardiac tissues of rats fed a high-fat diet.
PG  - 344
LID - 10.1186/s12906-018-2400-9 [doi]
LID - 344
AB  - BACKGOUND: Chronic fat-rich diets consumption is increased risk associated with 
      cardiovascular diseases (CVD). Prevention or reduction the progression of cardiac 
      tissue deterioration could benefit in CVD. This study aimed to examine the 
      effects of maoberry (Antidesma bunius), a antioxidant-rich tropical fruit, 
      supplementation on oxidative stress and inflammation in cardiac tissues of rats 
      fed a high-fat diet (HFD). METHODS: The male rats orally received HFD with 
      maoberry extract doses of 0.38, 0.76 or 1.52 g/kg or simvastatin (10 mg/kg) for 
      12 weeks. At the end of the experimental period, the rats were fasted, euthanized 
      and harvested for the hearts. RESULTS: Significantly reduced oxidative stress 
      (malondialdehyde levels) and enhanced antioxidant capacity (ferric-reducing 
      activities) in cardiac tissues of the rats were found. Maoberry extract 
      remarkably ameliorated the expressions of genes involved with pro-inflammatory 
      such as the tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), vascular 
      cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1) and 
      endothelial nitric oxide synthase (eNOS). CONCLUSIONS: Our findings suggest that 
      maoberry extract has remarkable effects on preventing progression of cardiac 
      tissue deterioration at least through lowering oxidative stress and inflammation.
FAU - Udomkasemsab, Arunwan
AU  - Udomkasemsab A
AD  - Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, 
      Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok, Thailand.
FAU - Ngamlerst, Chattraya
AU  - Ngamlerst C
AD  - Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
FAU - Adisakwattana, Poom
AU  - Adisakwattana P
AD  - Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, 
      Bangkok, Thailand.
FAU - Aroonnual, Amornrat
AU  - Aroonnual A
AD  - Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, 
      Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok, Thailand.
FAU - Tungtrongchitr, Rungsunn
AU  - Tungtrongchitr R
AD  - Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, 
      Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok, Thailand.
FAU - Prangthip, Pattaneeya
AU  - Prangthip P
AUID- ORCID: 0000-0002-0316-9528
AD  - Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, 
      Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok, Thailand. 
      pattaneeya.pra@mahidol.ac.th.
LA  - eng
GR  - MRG6180101./the Faculty of Tropical Medicine and Thailand Research Fund (TRF)/
PT  - Journal Article
DEP - 20181227
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/*drug therapy/immunology/metabolism
MH  - Chemokine CCL2/genetics/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Heart/*drug effects
MH  - Humans
MH  - Interleukin-6/genetics/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Malpighiales/*chemistry
MH  - Myocardium/immunology/*metabolism
MH  - Nitric Oxide Synthase Type III/genetics/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Plant Extracts/*administration & dosage/chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
MH  - Vascular Cell Adhesion Molecule-1/genetics/metabolism
PMC - PMC6307262
OTO - NOTNLM
OT  - Cardiac tissue
OT  - Inflammation
OT  - Maoberry
OT  - Oxidative stress
COIS- AUTHORS' INFORMATION: PP did her PhD (Nutrition) in The Institute of Nutrition, 
      Mahidol University. She is working as Assistant Professor at the Department of 
      Tropical Nutrition and Food Science, Mahidol University, Bangkok, Thailand. 
      ETHICS APPROVAL AND CONSENT TO PARTICIPATE: This study makes use of rats under 
      rules and regulations of the Animal Care Ethical Committee of Laboratory Animal 
      Science Center, Faculty of Tropical Medicine, Mahidol University (Approval no. 
      FTM-ACUC 011/2018). CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: 
      The authors declare that they have no competing interests. PUBLISHER'S NOTE: 
      Springer Nature remains neutral with regard to jurisdictional claims in published 
      maps and institutional affiliations.
EDAT- 2018/12/29 06:00
MHDA- 2019/01/12 06:00
PMCR- 2018/12/27
CRDT- 2018/12/29 06:00
PHST- 2018/08/09 00:00 [received]
PHST- 2018/12/04 00:00 [accepted]
PHST- 2018/12/29 06:00 [entrez]
PHST- 2018/12/29 06:00 [pubmed]
PHST- 2019/01/12 06:00 [medline]
PHST- 2018/12/27 00:00 [pmc-release]
AID - 10.1186/s12906-018-2400-9 [pii]
AID - 2400 [pii]
AID - 10.1186/s12906-018-2400-9 [doi]
PST - epublish
SO  - BMC Complement Altern Med. 2018 Dec 27;18(1):344. doi: 10.1186/s12906-018-2400-9.