PMID- 30591767
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2090-911X (Electronic)
IS  - 1110-2608 (Print)
IS  - 1110-2608 (Linking)
VI  - 70
IP  - 4
DP  - 2018 Dec
TI  - Acute effect of primary PCI on diastolic dysfunction recovery in anterior wall 
      STEMI - A non-invasive evaluation by echocardiography.
PG  - 427-432
LID - 10.1016/j.ehj.2018.10.004 [doi]
AB  - BACKGROUND: It is well established fact that acute coronary occlusion leads to 
      diastolic dysfunction, followed by systolic dysfunction when myonecrosis occur. 
      It is also proven that primary percutaneous coronary intervention (PPCI) is an 
      excellent therapy for ST elevation myocardial infarction (STEMI) to improve 
      outcomes. However there is a paucity of information on efficacy of PPCI in 
      improving diastolic function. Evaluation of the role of PPCI in improving 
      diastolic dysfunction is required. METHODS: 61 patients with first anterior wall 
      STEMI who underwent PPCI to left anterior descending artery were included. 
      Echocardiographic evaluation was performed within 24 h of PPCI and then on day 
      15, 3 months and 6 months after PPCI. We evaluated the prevalence of diastolic 
      dysfunction after PPCI and its recovery during 6 months along with effect of 
      duration of chest pain on diastolic function. RESULTS: 54.1% of patients had 
      diastolic dysfunction after PPCI whereas it was only 21.3% after 6 months (p 
      value < 0.001). Diastolic function indices like deceleration time, isovolumic 
      relaxation time, E wave, A wave, E/A ratio, left atrial volume and index improved 
      statistically from baseline to 6 months except mitral E/e' ratio. As time 
      required to achieve reperfusion increases (chest pain duration and D to B time) 
      the incidence of residual diastolic dysfunction also increases (p value < 0.001). 
      Patients with TIMI flow < III had more diastolic dysfunction (p value < 0.001). 
      CONCLUSIONS: Primary PCI improves diastolic dysfunction in patients with anterior 
      wall STEMI over a period of 6 months. Time to achieve reperfusion and 
      effectiveness of reperfusion have significant effect on diastolic dysfunction.
FAU - Subramaniyan, Siva
AU  - Subramaniyan S
AD  - Department of Cardiology, Guru Gobind Singh Indraprastha University, India.
FAU - Pandit, Neeraj
AU  - Pandit N
AD  - Department of Cardiology, Guru Gobind Singh Indraprastha University, India.
FAU - Kumar Nath, Ranjit
AU  - Kumar Nath R
AD  - Department of Cardiology, Guru Gobind Singh Indraprastha University, India.
FAU - Raj, Ajay
AU  - Raj A
AD  - Department of Cardiology, Guru Gobind Singh Indraprastha University, India.
FAU - Kamal, Athar
AU  - Kamal A
AD  - Department of Cardiology, Guru Gobind Singh Indraprastha University, India.
FAU - Vatsa, Deepankar
AU  - Vatsa D
AD  - Department of Cardiology, Guru Gobind Singh Indraprastha University, India.
LA  - eng
PT  - Journal Article
DEP - 20181022
PL  - Germany
TA  - Egypt Heart J
JT  - The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of 
      Cardiology
JID - 9106952
PMC - PMC6303523
OTO - NOTNLM
OT  - Deceleration time
OT  - Diastolic dysfunction
OT  - Isovolumic relaxation time
OT  - Primary percutaneous coronary intervention
OT  - ST elevation myocardial infarction
EDAT- 2018/12/29 06:00
MHDA- 2018/12/29 06:01
PMCR- 2018/10/22
CRDT- 2018/12/29 06:00
PHST- 2018/06/01 00:00 [received]
PHST- 2018/10/03 00:00 [accepted]
PHST- 2018/12/29 06:00 [entrez]
PHST- 2018/12/29 06:00 [pubmed]
PHST- 2018/12/29 06:01 [medline]
PHST- 2018/10/22 00:00 [pmc-release]
AID - S1110-2608(18)30120-0 [pii]
AID - 10.1016/j.ehj.2018.10.004 [doi]
PST - ppublish
SO  - Egypt Heart J. 2018 Dec;70(4):427-432. doi: 10.1016/j.ehj.2018.10.004. Epub 2018 
      Oct 22.