PMID- 30591957
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2472-1972 (Electronic)
IS  - 2472-1972 (Linking)
VI  - 3
IP  - 1
DP  - 2019 Jan 1
TI  - Increased Rates of Meal Absorption Do Not Explain Elevated 1-Hour Glucose in 
      Subjects With Normal Glucose Tolerance.
PG  - 135-145
LID - 10.1210/js.2018-00222 [doi]
AB  - CONTEXT: In subjects with normal fasting glucose (NFG) and normal glucose 
      tolerance (NGT), glucose concentrations >155 mg/dL 1 hour after 75 g of oral 
      glucose predict increased risk of progression to diabetes. Recently, it has been 
      suggested that the mechanism underlying this abnormality is increased gut 
      absorption of glucose. OBJECTIVE: We sought to determine the rate of systemic 
      appearance of meal-derived glucose in subjects classified by their 1-hour glucose 
      after a 75-g oral glucose challenge. DESIGN: This was a cross-sectional study. 
      Participating subjects underwent a 75-g oral glucose challenge and a labeled 
      mixed meal test. SETTING: An inpatient clinical research unit at an academic 
      medical center. PARTICIPANTS: Thirty-six subjects with NFG/NGT participated in 
      this study. INTERVENTIONS: Subjects underwent an oral glucose tolerance test. 
      Subsequently, they underwent a labeled mixed meal to measure fasting and 
      postprandial glucose metabolism. MAIN OUTCOME MEASURES: We examined beta-cell 
      function and the rate of meal appearance (Meal R(a)) in NFG/NGT subjects. 
      Subsequently, we examined the relationship of peak postchallenge glucose with 
      Meal R(a) and indices of beta-cell function. RESULTS: Peak glucose concentrations 
      correlated inversely with beta-cell function. No relationship of Meal R(a) with peak 
      postchallenge glucose concentrations was observed. CONCLUSION: In subjects with 
      NFG/NGT, elevated 1-hour peak postchallenge glucose concentrations reflect 
      impaired beta-cell function rather than increased systemic meal appearance.
FAU - Adams, J D
AU  - Adams JD
AD  - Division of Endocrinology, Diabetes, and Metabolism, Mayo Clinic, Rochester, 
      Minnesota.
FAU - Treiber, Gerlies
AU  - Treiber G
AD  - Department of Internal Medicine, Division of Endocrinology and Diabetology, 
      Medical University of Graz, Graz, Austria.
FAU - Hurtado, Maria Daniela
AU  - Hurtado MD
AD  - Division of Endocrinology, Diabetes, and Metabolism, Mayo Clinic, Rochester, 
      Minnesota.
FAU - Laurenti, Marcello C
AU  - Laurenti MC
AD  - Department of Information Engineering, Universita di Padova, 36131 Padova, Italy.
FAU - Dalla Man, Chiara
AU  - Dalla Man C
AD  - Department of Information Engineering, Universita di Padova, 36131 Padova, Italy.
FAU - Cobelli, Claudio
AU  - Cobelli C
AD  - Department of Information Engineering, Universita di Padova, 36131 Padova, Italy.
FAU - Rizza, Robert A
AU  - Rizza RA
AD  - Division of Endocrinology, Diabetes, and Metabolism, Mayo Clinic, Rochester, 
      Minnesota.
FAU - Vella, Adrian
AU  - Vella A
AUID- ORCID: 0000-0001-6493-7837
AD  - Division of Endocrinology, Diabetes, and Metabolism, Mayo Clinic, Rochester, 
      Minnesota.
LA  - eng
GR  - R01 DK078646/DK/NIDDK NIH HHS/United States
GR  - R01 DK116231/DK/NIDDK NIH HHS/United States
GR  - T32 DK007352/DK/NIDDK NIH HHS/United States
GR  - UL1 TR000135/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20181121
PL  - United States
TA  - J Endocr Soc
JT  - Journal of the Endocrine Society
JID - 101697997
EIN - J Endocr Soc. 2019 Jan 11;3(3):516. PMID: 30788453
PMC - PMC6302905
OTO - NOTNLM
OT  - 60-min glucose
OT  - disposition index
OT  - splanchnic glucose uptake
EDAT- 2018/12/29 06:00
MHDA- 2018/12/29 06:01
PMCR- 2018/11/21
CRDT- 2018/12/29 06:00
PHST- 2018/07/23 00:00 [received]
PHST- 2018/11/16 00:00 [accepted]
PHST- 2018/12/29 06:00 [entrez]
PHST- 2018/12/29 06:00 [pubmed]
PHST- 2018/12/29 06:01 [medline]
PHST- 2018/11/21 00:00 [pmc-release]
AID - js_201800222 [pii]
AID - 10.1210/js.2018-00222 [doi]
PST - epublish
SO  - J Endocr Soc. 2018 Nov 21;3(1):135-145. doi: 10.1210/js.2018-00222. eCollection 
      2019 Jan 1.