PMID- 30593105
OWN - NLM
STAT- MEDLINE
DCOM- 20190506
LR  - 20211204
IS  - 2618-0456 (Electronic)
IS  - 1000-1182 (Print)
IS  - 1000-1182 (Linking)
VI  - 36
IP  - 6
DP  - 2018 Dec 1
TI  - [Clinical importance of microtubule-associated protein 1 light chain 3 and 
      mammalian target of rapamycin expression in oral leukoplakia and oral squamous 
      cell carcinoma].
PG  - 613-618
LID - 10.7518/hxkq.2018.06.006 [doi]
AB  - OBJECTIVE: This study aimed to investigate the expression and relationship of 
      microtubule-associated protein 1 light chain 3 (LC3) and mammalian target of 
      rapamycin (mTOR) in normal oral mucosa, oral leukoplakia (OLK), and oral squamous 
      cell carcinoma (OSCC). This work also analyzed the relationship between 
      expression levels and clinical factors. This study evaluated the clinical value 
      of LC3B and mTOR as indices to determine the carcinogenic potential of OLK. 
      METHODS: Immunohistochemistry was used to detect the expression of LC3B and mTOR 
      in 20 cases of normal oral mucosa, 120 cases of OLK, and 30 cases of OSCC. The 
      clinical data of 120 patients with OLK were analyzed. The relationships between 
      expression levels and clinical factors were investigated. RESULTS: In normal oral 
      mucosa, OLK and OSCC, the positive rates of LC3B expression were 85.0%, 65.8% and 
      33.3% (P<0.05), whereas the positive rates of mTOR expression were 20.0%, 48.3% 
      and 76.7% (P<0.05). The expression levels of LC3B and mTOR were correlated and 
      related to clinical typing of OLK (P<0.05). CONCLUSIONS: LC3B and mTOR can be 
      used as molecular biomarkers for early detection of OLK.
FAU - Dong, Xiao-Lin
AU  - Dong XL
AD  - Stomatological Center, Xiangya Second Hospital of Central South University, 
      Changsha 410011, China.
FAU - Liu, Zhi-Wen
AU  - Liu ZW
AD  - Stomatological Center, Xiangya Second Hospital of Central South University, 
      Changsha 410011, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Hua Xi Kou Qiang Yi Xue Za Zhi
JT  - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal 
      of stomatology
JID - 9422648
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MAP1LC3A protein, human)
RN  - 0 (Microtubule-Associated Proteins)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - *Biomarkers, Tumor/metabolism
MH  - *Carcinoma, Squamous Cell/diagnosis/metabolism
MH  - Humans
MH  - *Leukoplakia, Oral/diagnosis/metabolism
MH  - *Microtubule-Associated Proteins/metabolism
MH  - Mouth Mucosa
MH  - *Mouth Neoplasms/diagnosis/metabolism
MH  - *TOR Serine-Threonine Kinases/metabolism
PMC - PMC7039799
OTO - NOTNLM
OT  - leukoplakia
OT  - mammalian target of rapamycin
OT  - microtubule-associated protein 1 light chain 3
EDAT- 2018/12/29 06:00
MHDA- 2019/05/07 06:00
PMCR- 2018/12/01
CRDT- 2018/12/29 06:00
PHST- 2018/12/29 06:00 [entrez]
PHST- 2018/12/29 06:00 [pubmed]
PHST- 2019/05/07 06:00 [medline]
PHST- 2018/12/01 00:00 [pmc-release]
AID - wcjs-36-06-613 [pii]
AID - 10.7518/hxkq.2018.06.006 [doi]
PST - ppublish
SO  - Hua Xi Kou Qiang Yi Xue Za Zhi. 2018 Dec 1;36(6):613-618. doi: 
      10.7518/hxkq.2018.06.006.