PMID- 30593140
OWN - NLM
STAT- MEDLINE
DCOM- 20190104
LR  - 20231005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 52
DP  - 2018 Dec
TI  - Increased risk of appendectomy in patients with gastroesophageal reflux disease: 
      A nested case-control study using a national sample cohort.
PG  - e13700
LID - 10.1097/MD.0000000000013700 [doi]
LID - e13700
AB  - The purpose of this study is to confirm and complement previous data regarding an 
      association between gastroesophageal reflux disease and appendectomy.The Korean 
      National Health Insurance Service-National Sample Cohort includes data from 
      people >/= 20 years old collected from 2002 to 2013. A total of 13,484 participants 
      who received an appendectomy were matched with 53,936 controls at a 1:4 ratio. We 
      analyzed the previous histories of gastroesophageal reflux disease (GERD) in the 
      appendectomy and control groups. Appendectomies were identified using operation 
      codes (Q2860-Q2863) exclusive for appendicitis (International Classification of 
      Disease-10 (ICD-10): K35). GERD was defined using the ICD-10 (K21), and patients 
      who were treated >/= 2 times and were prescribed a proton pump inhibitor (PPI) for 
      >/= 2 weeks were included. Crude (simple) and adjusted odds ratios (ORs) for GERD 
      and appendectomy were analyzed using conditional logistic regression analyses.A 
      higher GERD rate was detected in the appendectomy group (11.4% [1,713/15,062]) 
      than in the control group (8.2% [4,947/60,248], P < .001). Adjusted ORs for GERD 
      were 1.37 (95% confidence interval [CI] = 1.30-1.45) (P < .001). Subgroup 
      analyses stratified according to age and sex revealed consistent findings. The 
      adjusted OR for GERD in participants prescribed PPIs for >/= 30 days was 1.31 (95% 
      CI = 1.20-1.43), and the adjusted OR for GERD in participants prescribed PPIs for 
      >/= 60 days was 1.30 (95% CI = 1.15-1.48).The Odds for GERD were higher in the 
      appendectomy group than in the control group.
FAU - Kim, So Young
AU  - Kim SY
AD  - Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical 
      Center, CHA University, Seongnam.
FAU - Kim, Hyung-Jong
AU  - Kim HJ
AD  - Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College 
      of Medicine.
FAU - Lim, Hyun
AU  - Lim H
AD  - Department of Internal Medicine, Hallym University College of Medicine, Anyang.
FAU - Lim, Man Sup
AU  - Lim MS
AD  - Department of General Surgery, Hallym University College of Medicine, Chuncheon.
FAU - Kim, Miyoung
AU  - Kim M
AD  - Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, 
      Republic of Korea.
FAU - Choi, Hyo Geun
AU  - Choi HG
AD  - Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College 
      of Medicine.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Appendectomy/*statistics & numerical data
MH  - Appendicitis/epidemiology/etiology/*surgery
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Female
MH  - Gastroesophageal Reflux/*complications/drug therapy
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - National Health Programs/statistics & numerical data
MH  - Odds Ratio
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
MH  - Young Adult
PMC - PMC6314750
COIS- All authors have no conflict of interests to declare.
EDAT- 2018/12/30 06:00
MHDA- 2019/01/05 06:00
PMCR- 2018/12/28
CRDT- 2018/12/30 06:00
PHST- 2018/12/30 06:00 [entrez]
PHST- 2018/12/30 06:00 [pubmed]
PHST- 2019/01/05 06:00 [medline]
PHST- 2018/12/28 00:00 [pmc-release]
AID - 00005792-201812280-00016 [pii]
AID - MD-D-18-07177 [pii]
AID - 10.1097/MD.0000000000013700 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Dec;97(52):e13700. doi: 10.1097/MD.0000000000013700.