PMID- 30593189
OWN - NLM
STAT- MEDLINE
DCOM- 20190114
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 52
DP  - 2018 Dec
TI  - A comprehensive comparison of fluorescence in situ hybridization and cytology for 
      the detection of upper urinary tract urothelial carcinoma: A systematic review 
      and meta-analysis.
PG  - e13859
LID - 10.1097/MD.0000000000013859 [doi]
LID - e13859
AB  - OBJECTIVE: To compare the relative effectiveness of fluorescence in situ 
      hybridization (FISH) and cytology in diagnosing upper urinary tract urothelial 
      carcinoma (UUT-UC) and to evaluate the advantages and potential deficiencies of 
      FISH analysis. METHODS: We performed a complete systematic review based on 
      studies from PubMed/Medline, Embase, Web of Science, Ovid, Web of Knowledge, and 
      Cochrane Library. We identified 2031 patients with strict criteria in 14 
      individual studies between January 2005 to November 2017 in accordance to 
      preferred reporting items for systematic reviews and meta-analysis (PRISMA) 
      guidelines, we summarized the test performance using bivariate random effects 
      models. RESULTS: FISH was superior to cytology in terms of pooled sensitivities 
      (84.0%, 95% confidence interval [CI] 74.4-90.5% vs 40.0%, 95% CI 33.6-46.7%). 
      FISH and cytology were similar to each other in terms of pooled specificities, 
      which were 89.5% (95% CI 85.3-92.6%) for FISH and 95.9% (95% CI 91.2-98.1%) for 
      cytology. CONCLUSION: We confirm the superiority of FISH over cytology in terms 
      of sensitivity and find similar diagnostic outcomes between them based on 
      systematic analysis. Therefore, we demonstrate that FISH is extremely sensitive 
      while still very reliable with a relatively low error rate for diagnosing UUT-UC.
FAU - Jin, Hongyu
AU  - Jin H
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University.
AD  - West China School of Medicine, Sichuan University, Chengdu, Sichuan Province, 
      China.
FAU - Lin, Tianhai
AU  - Lin T
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University.
FAU - Hao, Jianqi
AU  - Hao J
AD  - West China School of Medicine, Sichuan University, Chengdu, Sichuan Province, 
      China.
FAU - Qiu, Shi
AU  - Qiu S
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University.
FAU - Xu, Hang
AU  - Xu H
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University.
FAU - Yu, Ruichao
AU  - Yu R
AD  - Department of Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center.
FAU - Sun, Sheng
AU  - Sun S
AD  - Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA.
FAU - Zhang, Peng
AU  - Zhang P
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University.
FAU - Liu, Zhenhua
AU  - Liu Z
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University.
FAU - Yang, Lu
AU  - Yang L
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University.
FAU - Liu, Liangren
AU  - Liu L
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University.
FAU - Han, Ping
AU  - Han P
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University.
FAU - Wei, Qiang
AU  - Wei Q
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Carcinoma, Transitional Cell/*pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods/*standards
MH  - Urologic Neoplasms/*pathology
PMC - PMC6314722
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2018/12/30 06:00
MHDA- 2019/01/15 06:00
PMCR- 2018/12/28
CRDT- 2018/12/30 06:00
PHST- 2018/12/30 06:00 [entrez]
PHST- 2018/12/30 06:00 [pubmed]
PHST- 2019/01/15 06:00 [medline]
PHST- 2018/12/28 00:00 [pmc-release]
AID - 00005792-201812280-00065 [pii]
AID - MD-D-18-04147 [pii]
AID - 10.1097/MD.0000000000013859 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Dec;97(52):e13859. doi: 10.1097/MD.0000000000013859.