PMID- 30593923
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20200225
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 399
DP  - 2019 Feb 10
TI  - Synaptic Reorganization Response in the Cochlear Nucleus Following Intense Noise 
      Exposure.
PG  - 184-198
LID - S0306-4522(18)30839-X [pii]
LID - 10.1016/j.neuroscience.2018.12.023 [doi]
AB  - The cochlear nucleus, located in the brainstem, receives its afferent auditory 
      input exclusively from the auditory nerve fibers of the ipsilateral cochlea. 
      Noise-induced neurodegenerative changes occurring in the auditory nerve stimulate 
      a cascade of neuroplastic changes in the cochlear nucleus resulting in major 
      changes in synaptic structure and function. To identify some of the key molecular 
      mechanisms mediating this synaptic reorganization, we unilaterally exposed rats 
      to a high-intensity noise that caused significant hearing loss and then measured 
      the resulting changes in a synaptic plasticity gene array targeting neurogenesis 
      and synaptic reorganization. We compared the gene expression patterns in the 
      dorsal cochlear nucleus (DCN) and ventral cochlear nucleus (VCN) on the 
      noise-exposed side versus the unexposed side using a PCR gene array at 2 d 
      (early) and 28 d (late) post-exposure. We discovered a number of differentially 
      expressed genes, particularly those related to synaptogenesis and regeneration. 
      Significant gene expression changes occurred more frequently in the VCN than the 
      DCN and more changes were seen at 28  d versus 2 d post-exposure. We confirmed 
      the PCR findings by in situ hybridization for Brain-derived neurotrophic factor 
      (Bdnf), Homer-1, as well as the glutamate NMDA receptor Grin1, all involved in 
      neurogenesis and plasticity. These results suggest that Bdnf, Homer-1 and Grin1 
      play important roles in synaptic remodeling and homeostasis in the cochlear 
      nucleus following severe noise-induced afferent degeneration.
CI  - Copyright (c) 2018 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Manohar, S
AU  - Manohar S
AD  - University at Buffalo, Center for Hearing and Deafness, 3435 Main Street, Cary 
      137, Buffalo, NY 14214, United States.
FAU - Ramchander, P V
AU  - Ramchander PV
AD  - University at Buffalo, Center for Hearing and Deafness, 3435 Main Street, Cary 
      137, Buffalo, NY 14214, United States.
FAU - Salvi, R
AU  - Salvi R
AD  - University at Buffalo, Center for Hearing and Deafness, 3435 Main Street, Cary 
      137, Buffalo, NY 14214, United States. Electronic address: salvi@buffalo.edu.
FAU - Seigel, G M
AU  - Seigel GM
AD  - University at Buffalo, Center for Hearing and Deafness, 3435 Main Street, Cary 
      137, Buffalo, NY 14214, United States.
LA  - eng
GR  - R01 DC011808/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20181226
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Homer Scaffolding Proteins)
RN  - 0 (Homer1 protein, rat)
RN  - 0 (NMDA receptor A1)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Acoustic Stimulation/adverse effects
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cochlear Nucleus/pathology/*physiopathology
MH  - Disease Models, Animal
MH  - Evoked Potentials, Auditory, Brain Stem
MH  - Gene Expression Regulation
MH  - Hearing Loss, Noise-Induced/pathology/*physiopathology
MH  - Homer Scaffolding Proteins/metabolism
MH  - Neuronal Plasticity/*physiology
MH  - RNA, Messenger/metabolism
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
MH  - Synapses/pathology/*physiology
MH  - Time Factors
PMC - PMC6595490
MID - NIHMS1517468
OTO - NOTNLM
OT  - dorsal cochlear nucleus
OT  - gene expression
OT  - noise-induced hearing loss
OT  - synaptic plasticity
OT  - ventral cochlear nucleus
EDAT- 2018/12/30 06:00
MHDA- 2019/03/12 06:00
PMCR- 2020/02/10
CRDT- 2018/12/30 06:00
PHST- 2018/07/27 00:00 [received]
PHST- 2018/12/13 00:00 [revised]
PHST- 2018/12/14 00:00 [accepted]
PHST- 2018/12/30 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/12/30 06:00 [entrez]
PHST- 2020/02/10 00:00 [pmc-release]
AID - S0306-4522(18)30839-X [pii]
AID - 10.1016/j.neuroscience.2018.12.023 [doi]
PST - ppublish
SO  - Neuroscience. 2019 Feb 10;399:184-198. doi: 10.1016/j.neuroscience.2018.12.023. 
      Epub 2018 Dec 26.