PMID- 30594347
OWN - NLM
STAT- MEDLINE
DCOM- 20190830
LR  - 20190830
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 278
DP  - 2019 Mar 1
TI  - Safety and effectiveness of home-based, self-selected exercise training in 
      symptomatic adults with congenital heart disease: A prospective, randomised, 
      controlled trial.
PG  - 59-64
LID - S0167-5273(18)35637-7 [pii]
LID - 10.1016/j.ijcard.2018.12.042 [doi]
AB  - BACKGROUND: The purpose of this prospective randomised controlled trial was to 
      assess whether home-based, self-selected exercise training is safe, results in 
      high compliance and improves exercise capacity in symptomatic adults with 
      congenital heart disease (CHD). METHODS: Forty adults with moderate or severe CHD 
      (40 +/- 12 years, 56% male, New York Heart Association [NYHA] II/III 37/3) were 
      randomly assigned, stratified by CHD complexity, either to home-based exercise 
      training or usual care. The exercise training protocol consisted of three 
      exercise sessions per week for six consecutive months. Patients were free to 
      choose any sports of their preference. RESULTS: Thirty-four patients (each 
      randomisation group n = 17) completed the protocol and were analysed. The 
      majority was involved in high-dynamic sports (76%); none had to discontinue the 
      training programme due to exercise-related adverse events. More than 70% adhered 
      to the exercise programme at or above the target training level. Peak VO(2) 
      increased significantly in the exercise group by +1.7 +/- 2.7 ml∙kg∙min(-1) 
      (p = 0.025), whereas it remained unchanged in the control group by 
      +0.8 +/- 2.2 ml∙kg∙min(-1) (p = 0.184). No significant changes were found in serum 
      N-Terminal pro-brain natriuretic peptide levels or quality of life in either 
      randomisation group or between groups. CONCLUSIONS: In symptomatic adults with 
      moderate or severe CHD, home-based exercise training of their preference appeared 
      safe, with good compliance and favourable effects on exercise capacity. Our 
      results demonstrate that it is appropriate to stimulate our patients to regularly 
      perform moderate to vigorous physical activities, in absence of medical 
      restrictions.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - van Dissel, Alexandra C
AU  - van Dissel AC
AD  - Amsterdam UMC, University of Amsterdam, Heart Centre, Department of Clinical and 
      Experimental Cardiology, Cardiovascular Sciences, Amsterdam, The Netherlands; 
      Netherlands Heart Institute, Utrecht, The Netherlands.
FAU - Blok, Ilja M
AU  - Blok IM
AD  - Amsterdam UMC, University of Amsterdam, Heart Centre, Department of Clinical and 
      Experimental Cardiology, Cardiovascular Sciences, Amsterdam, The Netherlands.
FAU - Hooglugt, Jean-Luc Q
AU  - Hooglugt JQ
AD  - Amsterdam UMC, University of Amsterdam, Heart Centre, Department of Clinical and 
      Experimental Cardiology, Cardiovascular Sciences, Amsterdam, The Netherlands.
FAU - de Haan, Ferdinand H
AU  - de Haan FH
AD  - ACHIEVE Centre for Applied Research, Faculty of Health, University of Applied 
      Sciences, Amsterdam, The Netherlands.
FAU - Jorstad, Harald T
AU  - Jorstad HT
AD  - Amsterdam UMC, University of Amsterdam, Heart Centre, Department of Clinical and 
      Experimental Cardiology, Cardiovascular Sciences, Amsterdam, The Netherlands.
FAU - Mulder, Barbara J M
AU  - Mulder BJM
AD  - Amsterdam UMC, University of Amsterdam, Heart Centre, Department of Clinical and 
      Experimental Cardiology, Cardiovascular Sciences, Amsterdam, The Netherlands; 
      Netherlands Heart Institute, Utrecht, The Netherlands.
FAU - Bouma, Berto J
AU  - Bouma BJ
AD  - Amsterdam UMC, University of Amsterdam, Heart Centre, Department of Clinical and 
      Experimental Cardiology, Cardiovascular Sciences, Amsterdam, The Netherlands.
FAU - Winter, Michiel M
AU  - Winter MM
AD  - Amsterdam UMC, University of Amsterdam, Heart Centre, Department of Clinical and 
      Experimental Cardiology, Cardiovascular Sciences, Amsterdam, The Netherlands. 
      Electronic address: m.m.winter@amc.nl.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20181217
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Adult
MH  - Exercise/*physiology
MH  - Female
MH  - Heart Defects, Congenital/diagnosis/*mortality/*therapy
MH  - *Home Care Services
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mortality/trends
MH  - Netherlands/epidemiology
MH  - *Patient Compliance
MH  - Prospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Adults
OT  - Congenital heart disease
OT  - Exercise
OT  - Heart failure
OT  - Safety
EDAT- 2018/12/31 06:00
MHDA- 2019/08/31 06:00
CRDT- 2018/12/31 06:00
PHST- 2018/09/17 00:00 [received]
PHST- 2018/11/20 00:00 [revised]
PHST- 2018/12/13 00:00 [accepted]
PHST- 2018/12/31 06:00 [pubmed]
PHST- 2019/08/31 06:00 [medline]
PHST- 2018/12/31 06:00 [entrez]
AID - S0167-5273(18)35637-7 [pii]
AID - 10.1016/j.ijcard.2018.12.042 [doi]
PST - ppublish
SO  - Int J Cardiol. 2019 Mar 1;278:59-64. doi: 10.1016/j.ijcard.2018.12.042. Epub 2018 
      Dec 17.