PMID- 30594716
OWN - NLM
STAT- MEDLINE
DCOM- 20200720
LR  - 20200720
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 367
DP  - 2019 Apr 5
TI  - Gestational exposure to acrylamide inhibits mouse placental development in vivo.
PG  - 160-170
LID - S0304-3894(18)31210-X [pii]
LID - 10.1016/j.jhazmat.2018.12.061 [doi]
AB  - Acrylamide, a carcinogen and neurotoxic substance, recently has been discovered 
      in various heat-treated carbohydrate-rich foods. The aim of this study was to 
      investigate the effects of acrylamide exposure on placental development. Pregnant 
      mice received acrylamide by gavage at dosages of 0, 10, and 50 mg/kg/day from 
      gestational days (GD) 3 until GD 8 or GD 13. The results showed that acrylamide 
      feeding significantly decreased the numbers of viable embryos and increased the 
      numbers of resorbed embryos on GD 13. Acrylamide exposure reduced the absolute 
      and relative weight of placentas and embryos, and inhibited the development of 
      ectoplacental cone (EPC) and placenta, as shown by the atrophy of EPC and reduced 
      placental area. Acrylamide markedly reduced the numbers of labyrinth vessels. 
      Expression levels of most placental key genes such as Esx1, Hand1, and Hand2 mRNA 
      dramatically decreased in acrylamide-treated placentas. Furthermore, acrylamide 
      treatment inhibited proliferation and induced apoptosis of placentas, as shown by 
      decreased Ki67-positive cells and Bcl-2 protein, and increased the expression of 
      Bax, cleaved-caspase-3, and cleaved-caspase-8 proteins. In conclusion, our 
      results indicated that gestational exposure to acrylamide inhibits placental 
      development through dysregulation of placental key gene expression and labyrinth 
      vessels, suppression of proliferation, and apoptosis induction in mice.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Yu, Dainan
AU  - Yu D
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China.
FAU - Xie, Xingxing
AU  - Xie X
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China.
FAU - Qiao, Bo
AU  - Qiao B
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China.
FAU - Ge, Wenjing
AU  - Ge W
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China.
FAU - Gong, Lixin
AU  - Gong L
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China.
FAU - Luo, Dan
AU  - Luo D
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China.
FAU - Zhang, Dalei
AU  - Zhang D
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China.
FAU - Li, Yuezhen
AU  - Li Y
AD  - Jiangxi Provincial Key Laboratory of Reproductive Physiology and Pathology, 
      Medical Experimental Teaching Center, Nanchang University, Nanchang, Jiangxi, 
      330006, PR China.
FAU - Yang, Bei
AU  - Yang B
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China.
FAU - Kuang, Haibin
AU  - Kuang H
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China; Jiangxi Provincial Key Laboratory of Reproductive 
      Physiology and Pathology, Medical Experimental Teaching Center, Nanchang 
      University, Nanchang, Jiangxi, 330006, PR China. Electronic address: 
      kuanghaibin@ncu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181218
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 20R035KLCI (Acrylamide)
SB  - IM
MH  - Acrylamide/*toxicity
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Embryonic Development/drug effects
MH  - Female
MH  - *Maternal-Fetal Exchange
MH  - Mice
MH  - Placenta/blood supply/*drug effects
MH  - Placentation/drug effects
MH  - Pregnancy
OTO - NOTNLM
OT  - Acrylamide
OT  - Developmental toxicity
OT  - Ectoplacental cone
OT  - Placenta
EDAT- 2018/12/31 06:00
MHDA- 2020/07/21 06:00
CRDT- 2018/12/31 06:00
PHST- 2018/06/23 00:00 [received]
PHST- 2018/12/03 00:00 [revised]
PHST- 2018/12/17 00:00 [accepted]
PHST- 2018/12/31 06:00 [pubmed]
PHST- 2020/07/21 06:00 [medline]
PHST- 2018/12/31 06:00 [entrez]
AID - S0304-3894(18)31210-X [pii]
AID - 10.1016/j.jhazmat.2018.12.061 [doi]
PST - ppublish
SO  - J Hazard Mater. 2019 Apr 5;367:160-170. doi: 10.1016/j.jhazmat.2018.12.061. Epub 
      2018 Dec 18.