PMID- 30594847
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190311
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 66
DP  - 2019 Feb
TI  - Organochlorine pesticides and polychlorinated biphenyls (PCBs) in early adulthood 
      and blood lipids over a 23-year follow-up.
PG  - 24-35
LID - S1382-6689(18)30580-5 [pii]
LID - 10.1016/j.etap.2018.12.018 [doi]
AB  - BACKGROUND: Some evidence in humans suggests that persistent organic pollutants 
      (POPs), including organochlorine pesticides (OCPs) and polychlorinated biphenyls 
      (PCBs), may alter the blood lipid composition. This study analyzed associations 
      between serum POPs concentrations in young adulthood with blood lipid levels up 
      to 23 years later. METHODS: Serum POPs were measured in year 2 of follow-up 
      (n = 180 men and women, ages: 20-32y), and plasma lipids in follow-up years 2, 7, 
      10, 15, 20 and 25. 32 POPs were detectable in >/=75% of participants (23 PCBs, 8 
      OCPs and PBB-153). We created summary scores for PCBs and OCPs for both 
      wet-weight, and lipid standardized (LP) concentrations. We used repeated measures 
      regression adjusting for demographic factors, BMI, smoking, diabetes status, 
      among others. RESULTS: We observed positive associations of the 23 LP-PCB score 
      with total cholesterol (beta(per SD increase) [95%CI]: 5.0 mg/dL [0.7, 9.2]), 
      triglycerides (7.8 mg/dL [-0.9, 16.5]), LDL (4.2 mg/dL [0.2, 8.2]), oxidized LDL 
      3.4 U/L (-0.05, 6.8), and cholesterol/HDL ratio (0.2 [0.02, 0.3]). The 
      associations for triglycerides (14.7 mg/dL [0.4, 20.1]), cholesterol/HDL (0.33 
      [0.09, 0.56]) and, to some extent, LDL (4.7 md/dL [-1.6, 10.9]) were only 
      observed among participants in the upper 50th percentile of BMI. Non-dioxin-like 
      PCBs had stronger associations that dioxin-like PCBs. OCPs and PBB-s had positive 
      associations with most outcomes. CONCLUSIONS: PCBs and PBB-153 measured in young 
      adulthood were positively associated with prospective alterations in most blood 
      lipid components, with evidence of effect modification by BMI. Further 
      longitudinal studies with multiple measures of POPs overtime are needed.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Suarez-Lopez, Jose R
AU  - Suarez-Lopez JR
AD  - Department of Family Medicine and Public Health, University of California, 9500 
      Gilman Drive #0725, La Jolla, San Diego, CA 92093-0725, USA. Electronic address: 
      jrsuarez@ucsd.edu.
FAU - Clemesha, Chase G
AU  - Clemesha CG
AD  - Department of Family Medicine and Public Health, University of California, 9500 
      Gilman Drive #0725, La Jolla, San Diego, CA 92093-0725, USA. Electronic address: 
      clemesha@ucsd.edu.
FAU - Porta, Miquel
AU  - Porta M
AD  - Hospital del Mar Institute of Medical Research (IMIM), School of Medicine, 
      Universitat Autonoma de Barcelona, and CIBERESP, Carrer del Dr. Aiguader, 88, 
      E-08003 Barcelona, Catalonia, Spain. Electronic address: mporta@imim.es.
FAU - Gross, Myron D
AU  - Gross MD
AD  - Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 609 
      Mayo 8609, 420 Delaware, Minneapolis, MN 55455, USA. Electronic address: 
      gross001@umn.edu.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, 101 Dongin-dong, Jung-gu, Daegu, 700-422, Republic of Korea. 
      Electronic address: lee_dh@knu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20181223
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Lipids)
RN  - 0 (Pesticides)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Environmental Exposure
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - Pesticides/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - Adults
OT  - Lipids
OT  - Longitudinal
OT  - Organochlorine
OT  - PCB
EDAT- 2018/12/31 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/12/31 06:00
PHST- 2018/05/11 00:00 [received]
PHST- 2018/10/31 00:00 [revised]
PHST- 2018/12/21 00:00 [accepted]
PHST- 2018/12/31 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/12/31 06:00 [entrez]
AID - S1382-6689(18)30580-5 [pii]
AID - 10.1016/j.etap.2018.12.018 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2019 Feb;66:24-35. doi: 10.1016/j.etap.2018.12.018. 
      Epub 2018 Dec 23.