PMID- 30595183
OWN - NLM
STAT- MEDLINE
DCOM- 20191021
LR  - 20191022
IS  - 1916-7075 (Electronic)
IS  - 0828-282X (Linking)
VI  - 35
IP  - 1
DP  - 2019 Jan
TI  - Myocardial Partition Coefficient of Gadolinium: A Pilot Study in Patients With 
      Acute Myocarditis, Chronic Myocardial Infarction, and in Healthy Volunteers.
PG  - 51-60
LID - S0828-282X(18)31223-6 [pii]
LID - 10.1016/j.cjca.2018.10.005 [doi]
AB  - BACKGROUND: The tissue-blood partition coefficient (PC) of gadolinium, derived 
      from T1 measurements, reflects myocardial connective tissue fraction and tissue 
      injury, increasing in proportion with edema or fibrosis. We determined the 
      myocardial PC of gadolinium in patients with acute myocarditis, chronic 
      myocardial infarction (MI), and healthy volunteers. We hypothesized that the 
      characteristics of the injured myocardium in patients with MI and myocarditis may 
      differ and that the PC will be higher in chronically injured myocardium (MI) 
      compared with acutely injured myocardium (myocarditis). METHODS: We performed 
      late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging 
      and T1 mapping before and after administration of gadolinium (0.1 mmol/kg 
      Gd-BOPTA) at 3 Tesla in 10 healthy volunteers (47.1 +/- 12.4 years), 18 patients 
      with chronic MI (62.5 +/- 8.1 years), and 16 patients with acute myocarditis (42.5 
      +/- 13.9 years). RESULTS: In patients with chronic MI and focal scar by LGE, the 
      whole left ventricular myocardial PC (0.45 +/- 0.05) was higher compared with 
      patients with MI without focal scar (0.39 +/- 0.03, P = 0.02) but not significantly 
      different from whole myocardial PC in volunteers (0.40 +/- 0.05) or patients with 
      myocarditis (0.41 +/- 0.05). The PC in myocarditis scars was lower than in chronic 
      MI scars (0.60 +/- 0.12 vs 0.77 +/- 0.16, P = 0.016). The relationships of PC and 
      scar burden, expressed as % LGE, were similar and significant for the 2 groups 
      (P = 0.042). CONCLUSION: The tissue-blood partition coefficient of Gd-BOPTA is 
      elevated in areas of acute and chronic myocardial injury and may serve as a 
      marker for disease activity and density of scars, which was found to be higher in 
      chronic MI than in acute myocarditis.
CI  - Copyright (c) 2018 Canadian Cardiovascular Society. Published by Elsevier Inc. All 
      rights reserved.
FAU - Teixeira, Tiago
AU  - Teixeira T
AD  - Philippa & Marvin Carsley CMR Center, Montreal Heart Institute, Universite de 
      Montreal, Montreal, Quebec, Canada; Centro Hospitalar entre Douro e Vouga, Sta 
      Maria da Feira, Portugal.
FAU - Hafyane, Tarik
AU  - Hafyane T
AD  - Philippa & Marvin Carsley CMR Center, Montreal Heart Institute, Universite de 
      Montreal, Montreal, Quebec, Canada.
FAU - Jerosch-Herold, Michael
AU  - Jerosch-Herold M
AD  - Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, Massachusetts.
FAU - Marcotte, Francois
AU  - Marcotte F
AD  - Philippa & Marvin Carsley CMR Center, Montreal Heart Institute, Universite de 
      Montreal, Montreal, Quebec, Canada.
FAU - Mongeon, Francois-Pierre
AU  - Mongeon FP
AD  - Philippa & Marvin Carsley CMR Center, Montreal Heart Institute, Universite de 
      Montreal, Montreal, Quebec, Canada. Electronic address: 
      francois.pierre.mongeon@umontreal.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181016
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 15G12L5X8K (gadobenic acid)
RN  - 6HG8UB2MUY (Meglumine)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Chronic Disease
MH  - Contrast Media/metabolism/pharmacokinetics
MH  - Coronary Circulation/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Injections, Intravenous
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Meglumine/administration & dosage/*analogs & derivatives/pharmacokinetics
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis/metabolism/physiopathology
MH  - Myocarditis/*diagnosis/metabolism/physiopathology
MH  - Myocardium/*metabolism/pathology
MH  - Organometallic Compounds/administration & dosage/*pharmacokinetics
MH  - Pilot Projects
MH  - Prospective Studies
EDAT- 2019/01/01 06:00
MHDA- 2019/10/23 06:00
CRDT- 2019/01/01 06:00
PHST- 2018/04/14 00:00 [received]
PHST- 2018/10/10 00:00 [revised]
PHST- 2018/10/10 00:00 [accepted]
PHST- 2019/01/01 06:00 [entrez]
PHST- 2019/01/01 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
AID - S0828-282X(18)31223-6 [pii]
AID - 10.1016/j.cjca.2018.10.005 [doi]
PST - ppublish
SO  - Can J Cardiol. 2019 Jan;35(1):51-60. doi: 10.1016/j.cjca.2018.10.005. Epub 2018 
      Oct 16.