PMID- 30595244
OWN - NLM
STAT- MEDLINE
DCOM- 20190206
LR  - 20200225
IS  - 2213-3763 (Electronic)
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 70 Suppl 3
IP  - Suppl 3
DP  - 2018 Dec
TI  - Prognostic significance of fragmented QRS in patients with ST-elevation 
      myocardial infarction undergoing revascularization.
PG  - S126-S132
LID - S0019-4832(18)30126-3 [pii]
LID - 10.1016/j.ihj.2018.07.014 [doi]
AB  - BACKGROUND & OBJECTIVES: This longitudinal study was carried out to evaluate the 
      prognostic significance of fragmented QRS (fQRS) in patients with acute ST 
      elevation myocardial infarction (STEMI) undergoing revascularization. METHODS: 
      This study included 103 STEMI patients belonging to Killip class I and II who 
      underwent primary revascularization. All patients underwent twelve lead ECG at 
      admission before PCI. Serial ECG were done after PCI at 3 hours, 6 hours, 24 
      hours, 48 hours and at discharge for detection of fQRS and echocardiography on 
      day 3 post revascularization. Patients developing fQRS within 48 hours and with 
      persistence of fQRS till discharge were included in "persistent fQRS" group. They 
      were followed up after 30 days for major adverse cardiac events (MACE) and 
      assessment of LV function by echocardiography. RESULTS: fQRS was present in 64 
      patients (61.5%) of study population with 37 patients (57.8%) having persistent 
      fQRS. MACE rates were low (4.8%) and did not differ with respect to fQRS. fQRS 
      significantly correlated with LV dysfunction at 30 days on univariate analysis 
      (p-0.003) but not on multivariate analysis (p -0.10). fQRS was significantly 
      related to impaired myocardial reperfusion as assessed by SigmaSTR (percent of total 
      ST segment resolution) (adjusted odds ratio, 95% CI [4.265 (1.034 - 17.58)], p = 
      0.04). CONCLUSION: In our study, fQRS did not predict MACE and LV dysfunction in 
      acute STEMI patients belonging to Killip class I and II on short term follow-up 
      of 30 days. But, fQRS independently predicted impaired microvascular myocardial 
      reperfusion as assessed by SigmaSTR.
CI  - Copyright (c) 2018 Cardiological Society of India. Published by Elsevier B.V. All 
      rights reserved.
FAU - Umapathy, Sridharan
AU  - Umapathy S
AD  - Department of Cardiology, AIIMS, New Delhi, India. Electronic address: 
      drsridhar87@gmail.com.
FAU - Yadav, Rakesh
AU  - Yadav R
AD  - Department of Cardiology, AIIMS, New Delhi, India.
FAU - Goswami, Kewal C
AU  - Goswami KC
AD  - Department of Cardiology, AIIMS, New Delhi, India.
FAU - Karthikeyan, Ganesan
AU  - Karthikeyan G
AD  - Department of Cardiology, AIIMS, New Delhi, India.
FAU - Parakh, Neeraj
AU  - Parakh N
AD  - Department of Cardiology, AIIMS, New Delhi, India.
FAU - Bahl, Vinay K
AU  - Bahl VK
AD  - Department of Cardiology, AIIMS, New Delhi, India.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180817
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
SB  - IM
MH  - Coronary Angiography
MH  - Echocardiography
MH  - Electrocardiography/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention/*methods
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
MH  - ST Elevation Myocardial Infarction/diagnosis/*physiopathology/surgery
MH  - Ventricular Function, Left/*physiology
PMC - PMC6309576
EDAT- 2019/01/01 06:00
MHDA- 2019/02/07 06:00
PMCR- 2019/12/01
CRDT- 2019/01/01 06:00
PHST- 2018/02/22 00:00 [received]
PHST- 2018/07/10 00:00 [revised]
PHST- 2018/07/28 00:00 [accepted]
PHST- 2019/01/01 06:00 [entrez]
PHST- 2019/01/01 06:00 [pubmed]
PHST- 2019/02/07 06:00 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - S0019-4832(18)30126-3 [pii]
AID - 10.1016/j.ihj.2018.07.014 [doi]
PST - ppublish
SO  - Indian Heart J. 2018 Dec;70 Suppl 3(Suppl 3):S126-S132. doi: 
      10.1016/j.ihj.2018.07.014. Epub 2018 Aug 17.