PMID- 30595251
OWN - NLM
STAT- MEDLINE
DCOM- 20190206
LR  - 20200225
IS  - 2213-3763 (Electronic)
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 70 Suppl 3
IP  - Suppl 3
DP  - 2018 Dec
TI  - Tumor necrosis factor-alpha -308G/A gene polymorphism and novel biomarker 
      profiles in patients with Takayasu arteritis.
PG  - S167-S172
LID - S0019-4832(18)30324-9 [pii]
LID - 10.1016/j.ihj.2018.09.004 [doi]
AB  - BACKGROUND: Takayasu arteritis (TA) is an idiopathic chronic inflammatory disease 
      of the aorta and its branches, leading to stenosis, occlusion, and aneurysmal 
      dilatation. Tumor necrosis factor-alpha (TNF-alpha) is a cytokine with pleomorphic 
      actions and plays a pivotal role in inflammation; the serum level of TNF-alpha is 
      genetically determined. However, the literature lacks adequate information on the 
      association of TNF-alpha polymorphisms with TA. Hence, the present study investigates 
      the contribution of TNF-alpha polymorphism toward the complex etiology of TA. 
      METHODS: A cross-sectional study was performed in 87 patients with TA and 90 
      controls. A promoter region polymorphism of TNF-alpha, rs1800629 G/A, or -308G/A was 
      genotyped in all the study subjects followed by a case-control association study. 
      Furthermore, to understand the biomarker profile, levels of specific markers such 
      as erythrocyte sedimentation rate, serum high-sensitivity C-reactive protein, 
      interleukin-18, interleukin-6, and TNF-alpha were measured in all the study subjects. 
      RESULTS: All the inflammatory markers were significantly higher in the TA 
      patients than in the controls. The genetic study (available for 57 TA patients 
      and 36 controls) revealed that the TNF-alpha -308A allele was overrepresented in the 
      TA patients (12% vs 7%). The TNF-alpha -308A allele correlated with the increased 
      TNF-alpha levels, but it could not attain significance because of a small sample 
      size. CONCLUSION: The TNF-alpha -308G/A polymorphism is associated with TNF-alpha levels 
      in Indian population, which might have implications for clinical risk 
      stratification and treatment. The different TNF-alpha gene promoter polymorphism 
      might contribute to the molecular pathogenesis of TA. However, further study of 
      the underlying mechanism is warranted.
CI  - Copyright (c) 2018 Cardiological Society of India. Published by Elsevier B.V. All 
      rights reserved.
FAU - Sarkar, Prattay Guha
AU  - Sarkar PG
AD  - GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, 
      India; Safdarjung Hospital and VMM College, India; Institute of Genomics and 
      Integrative Biology, India.
FAU - Gupta, Mohit Dayal
AU  - Gupta MD
AD  - GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, 
      India; Safdarjung Hospital and VMM College, India; Institute of Genomics and 
      Integrative Biology, India. Electronic address: drmohitgupta@yahoo.com.
FAU - Girish, M P
AU  - Girish MP
AD  - GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, 
      India; Safdarjung Hospital and VMM College, India; Institute of Genomics and 
      Integrative Biology, India.
FAU - Bansal, Ankit
AU  - Bansal A
AD  - GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, 
      India; Safdarjung Hospital and VMM College, India; Institute of Genomics and 
      Integrative Biology, India.
FAU - Kohli, Samantha
AU  - Kohli S
AD  - GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, 
      India; Safdarjung Hospital and VMM College, India; Institute of Genomics and 
      Integrative Biology, India.
FAU - Saijpaul, Rajni
AU  - Saijpaul R
AD  - GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, 
      India; Safdarjung Hospital and VMM College, India; Institute of Genomics and 
      Integrative Biology, India.
FAU - Tyagi, Sanjay
AU  - Tyagi S
AD  - GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, 
      India; Safdarjung Hospital and VMM College, India; Institute of Genomics and 
      Integrative Biology, India.
FAU - Pasha, Qadar
AU  - Pasha Q
AD  - GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, 
      India; Safdarjung Hospital and VMM College, India; Institute of Genomics and 
      Integrative Biology, India.
LA  - eng
PT  - Journal Article
DEP - 20181010
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
RN  - 0 (Biomarkers)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Biomarkers/metabolism
MH  - Child
MH  - Cross-Sectional Studies
MH  - DNA/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Single Nucleotide
MH  - Takayasu Arteritis/*genetics/metabolism
MH  - Tumor Necrosis Factor-alpha/*genetics/metabolism
MH  - Young Adult
PMC - PMC6310777
OTO - NOTNLM
OT  - Biomarkers
OT  - Gene polymorphism
OT  - Takayasu arteritis
OT  - Tumor necrosis factor-alpha
EDAT- 2019/01/01 06:00
MHDA- 2019/02/07 06:00
PMCR- 2019/12/01
CRDT- 2019/01/01 06:00
PHST- 2018/05/17 00:00 [received]
PHST- 2018/09/12 00:00 [revised]
PHST- 2018/09/20 00:00 [accepted]
PHST- 2019/01/01 06:00 [entrez]
PHST- 2019/01/01 06:00 [pubmed]
PHST- 2019/02/07 06:00 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - S0019-4832(18)30324-9 [pii]
AID - 10.1016/j.ihj.2018.09.004 [doi]
PST - ppublish
SO  - Indian Heart J. 2018 Dec;70 Suppl 3(Suppl 3):S167-S172. doi: 
      10.1016/j.ihj.2018.09.004. Epub 2018 Oct 10.