PMID- 30595263
OWN - NLM
STAT- MEDLINE
DCOM- 20190206
LR  - 20200225
IS  - 2213-3763 (Electronic)
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 70 Suppl 3
IP  - Suppl 3
DP  - 2018 Dec
TI  - Impact of obesity and surgical weight reduction on cardiac remodeling.
PG  - S224-S228
LID - S0019-4832(17)30958-6 [pii]
LID - 10.1016/j.ihj.2018.01.012 [doi]
AB  - BACKGROUND: the implication of obessity on cardiometabolic risk factors and 
      incident diabetes has been previously demonstrated, but the impact of weight 
      changes on cardiac structure independent of obesity-related comorbidities has not 
      been extensively studied AIM: to study impact of obesity and surgical weight 
      reduction on cardiac structure. PATIENTS AND METHODS: fifty two patients withbody 
      mass index (BMI) >/=40kg/m(2), free of previous or overt cardiac risk factors and 
      diseases were included, all patients underwent bariatric surgery; Conventional 
      echocardiography (2D, M-Mode, Doppler), tissue Doppler velocity (TDI), strain and 
      speckle tracking echocardiography for left and right ventricles were performed 
      before and 6m after surgery. RESULTS: mean age was 38.2+/-5.6, BMI 42.3+/-3.4kg/m(2), 
      65% were female and 35% were male. 6 months postopeatively; there was significant 
      increase of left ventricular end systolic volume (LVESV) and left ventricular end 
      diastolic volume (LVEDV) from 66.57+/-22 to 37.2+/-12 p<0.001, and 169.4+/-43.2 to 
      120.36+/-19.6ml with p<0.001 respectively and increased ejection fraction (EF%) 
      from 59+/-8 to 67+/-7ml p<0.001, significant reduction in left ventricular mass index 
      (LVMI) from 143+/-11 to 95.5+/-7gm/m(2) p<0.001. Significant increase in right 
      ventricular systolic area (RVSA) from 16.3+/-4.1 to 10.1+/-2.7cm(2) p<0.001 but was 
      insignificant in right ventricular diastolic area (RVDA) from 30.2+/-1.5 to 
      26.7+/-2cm(2) p=0.05, fraction area change (FAC) from 49.5+/-2.1 to 52+/-1.2% p=0.7, 
      Tricuspid annular plane systolic exertion (TAPSE) from 20.3+/-2.8to22.6+/-3.5mm, 
      p=0.56and pulmonary arterty systolic pressure (PASP) from 32.2+/-5.2 to 
      29.2+/-2.1mmHg, p=0.81.Early tissue Doppler diastolic velocity (Em) of the LV 
      increased from 7.1+/-2.1 to12+/-3.5 p<0.001 and that of RV from 6.2+/-2.8 to 9.2+/-1.4, 
      p=0.05 and tissue Doppler strain of the LV and RV invrased from -16.1+/-2.5 to 
      -22.8+/-3.1, p<0.001, -11.2+/- 2.6 to -17.3+/-3.4, p<0.001 respectively. Left 
      ventricular longtiduinal systolic strain (LVLPSS) increased from -17.2+/-2.1 to 
      -22.7+/-3.9 p<0.001 and right ventricular longtiduinal systolic strain (RVLPSS) 
      increased from -12.8+/-1.5 to -18.1+/-2.7 p<0.001. CONCLUSION: Obesity adversely 
      affects cardiac function independent of obesity-related comorbidities .Weight 
      reduction significantly increase the systolic and diastolic function of both 
      ventricles.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Mostfa, Shaimaa Ahmed
AU  - Mostfa SA
AD  - Cardiovascular Department, Benha Faculty of Medicine, Benha Univerisity, Egypt. 
      Electronic address: shaimaamustafa2011@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180109
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
SB  - IM
MH  - *Bariatric Surgery
MH  - Echocardiography, Doppler, Pulsed
MH  - Female
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Obesity/*physiopathology/surgery
MH  - Prospective Studies
MH  - Stroke Volume/*physiology
MH  - Ventricular Function, Right/*physiology
MH  - Ventricular Remodeling/*physiology
MH  - Weight Loss/*physiology
PMC - PMC6309118
OTO - NOTNLM
OT  - Obesity
OT  - Speckle tracking
OT  - Surgical weight reduction
EDAT- 2019/01/01 06:00
MHDA- 2019/02/07 06:00
PMCR- 2019/12/01
CRDT- 2019/01/01 06:00
PHST- 2017/11/27 00:00 [received]
PHST- 2018/01/08 00:00 [accepted]
PHST- 2019/01/01 06:00 [entrez]
PHST- 2019/01/01 06:00 [pubmed]
PHST- 2019/02/07 06:00 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - S0019-4832(17)30958-6 [pii]
AID - 10.1016/j.ihj.2018.01.012 [doi]
PST - ppublish
SO  - Indian Heart J. 2018 Dec;70 Suppl 3(Suppl 3):S224-S228. doi: 
      10.1016/j.ihj.2018.01.012. Epub 2018 Jan 9.