PMID- 30596765
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20200309
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 12
DP  - 2018
TI  - May the change of platelet to lymphocyte ratio be a prognostic factor for T3-T4 
      laryngeal squamous cell carcinoma: A retrospective study.
PG  - e0210033
LID - 10.1371/journal.pone.0210033 [doi]
LID - e0210033
AB  - BACKGROUND: Many blood markers have been shown to predict the recurrence and 
      survival of various malignancies, but the effects of surgery on the body's 
      inflammatory levels may cause changes in these inflammatory markers. Therefore, 
      in this study, we assessed the relationship between changes in platelet to 
      lymphocyte ratio (PLR) and survival and recurrence in patients with T3-T4 
      laryngeal squamous cell carcinoma (LSCC). METHODS: Data of patients with T3-T4 
      HSCC were reviewed. Continuous variables were expressed as mean +/- SD and were 
      compared using t test or Mann-Whitney U test. The covariate distributions were 
      compared by Chi-square test. Survival curve was estimated by Kaplan-Meier 
      analysis, and Log-Rank test were performed to estimate the survival curve and 
      significance of the difference in survival distribution between groups, 
      respectively. The prognostic value was uncovered by univariate and multivariate 
      Cox hazards analysis. RESULTS: The 413 consecutive patients with LSCC were 
      reviewed. Of these, 362 patients who met the criteria were selected, multi-factor 
      analysis found that pathological T classification(hazard ratio [HR] = 1.878; 95% 
      confidence interval [CI] = 1.342-3.023; P<0.001), pathological N classification 
      (HR = 1.212; 95% CI = 0.867-2.125; P< 0.001) and change of PLR (HR = 2.158; 95% 
      CI = 1.332-2.889; P = 0.004) associated with postoperative recurrence of T3-T4 
      LSCC. In addition, the pathological T classification (HR = 1.901; 95% CI = 
      1.255-2.999; P<0.001), pathological N classification (HR = 1.244; 95% CI = 
      0.810-2.212; P<0.001) and change of PLR (HR = 2.011; 95% CI = 1.354-2.753; P = 
      0.001) associated with postoperative survival in patients with T3-T4 LSCC. 
      CONCLUSIONS: Results demonstrate that change in PLR may serve as a useful 
      prognostic predictor for patients with T3-T4 LSCC.
FAU - Zhong, Bing
AU  - Zhong B
AUID- ORCID: 0000-0002-1783-0591
AD  - Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, 
      Sichuan University, Chengdu, Sichuan province, China.
FAU - Gu, De-Ying
AU  - Gu DY
AD  - Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, 
      Sichuan University, Chengdu, Sichuan province, China.
FAU - Du, Jin-Tao
AU  - Du JT
AD  - Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, 
      Sichuan University, Chengdu, Sichuan province, China.
FAU - Chen, Fei
AU  - Chen F
AD  - Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, 
      Sichuan University, Chengdu, Sichuan province, China.
FAU - Liu, Ya-Feng
AU  - Liu YF
AUID- ORCID: 0000-0002-6593-0589
AD  - Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, 
      Sichuan University, Chengdu, Sichuan province, China.
FAU - Liu, Shi-Xi
AU  - Liu SX
AD  - Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, 
      Sichuan University, Chengdu, Sichuan province, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20181231
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
EIN - PLoS One. 2019 Dec 5;14(12):e0226383. PMID: 31805159
MH  - Adult
MH  - Carcinoma, Squamous Cell/*blood/*mortality
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Laryngeal Neoplasms/*blood/*mortality
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Platelet Count
MH  - Retrospective Studies
MH  - Survival Rate
PMC - PMC6312301
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/01/01 06:00
MHDA- 2019/05/21 06:00
PMCR- 2018/12/31
CRDT- 2019/01/01 06:00
PHST- 2018/09/17 00:00 [received]
PHST- 2018/12/14 00:00 [accepted]
PHST- 2019/01/01 06:00 [entrez]
PHST- 2019/01/01 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2018/12/31 00:00 [pmc-release]
AID - PONE-D-18-26291 [pii]
AID - 10.1371/journal.pone.0210033 [doi]
PST - epublish
SO  - PLoS One. 2018 Dec 31;13(12):e0210033. doi: 10.1371/journal.pone.0210033. 
      eCollection 2018.