PMID- 30597378
OWN - NLM
STAT- MEDLINE
DCOM- 20200630
LR  - 20200630
IS  - 1878-0180 (Electronic)
IS  - 1878-0180 (Linking)
VI  - 91
DP  - 2019 Mar
TI  - The mechanics of scaling-up multichannel scaffold technology for clinical nerve 
      repair.
PG  - 247-254
LID - S1751-6161(18)31470-X [pii]
LID - 10.1016/j.jmbbm.2018.12.016 [doi]
AB  - Peripheral nerve injury remains a large clinical problem, with challenges to the 
      successful translation of nerve repair devices. One promising technology is the 
      multichannel scaffold, a conduit incorporating arrays of linear microchannels, 
      which has high open lumen volume to guide regenerating nerves toward distal 
      targets. To maximize open lumen volume, and scale-up scaffolds for translation, 
      this study explored how mechanical properties were affected by 1) material choice 
      (poly(lactide co-glycolide) (PLGA) and poly(caprolactone) (PCL)), 2) 
      microstructure (porous and non-porous), and 3) channel architecture (200 microm and 
      300 microm diameter). After testing in transverse compression and bending, it was 
      noted that introduction of porosity and increasing microchannel diameter 
      increased scaffold compliance from 0.05 +/- 0.1-2.75 +/- 0.8 mm/N. Porosity also 
      increased flexibility and eliminated kinking, which could potentially damage 
      regenerating nerves. Material choice determined both scaffold deformation and 
      mechanics. Porous PLGA scaffolds were stiffer than porous PCL, with greater 
      deformation. Having demonstrated stability and flexibility, porous PCL 
      multichannel scaffolds were scaled from 1.5 mm to 10 mm in diameter, a range 
      applicable to the clinic. Even at 10 mm in diameter, the linear structure, high 
      open lumen volume and compliance were retained. This demonstrates significant 
      progress towards translation and brings multichannel technology closer to the 
      clinic.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Pawelec, Kendell M
AU  - Pawelec KM
AD  - University of Michigan, Department of Mechanical Engineering, Ann Arbor, MI 
      48109, USA. Electronic address: kpawelec@umich.edu.
FAU - Hix, Jeremy
AU  - Hix J
AD  - Michigan State University, Department of Radiology, East Lansing, MI 48824, USA; 
      Institute for Quantitative Health Sciences and Engineering, Michigan State 
      University, East Lansing, MI 48823, USA.
FAU - Shapiro, Erik M
AU  - Shapiro EM
AD  - Michigan State University, Department of Radiology, East Lansing, MI 48824, USA; 
      Institute for Quantitative Health Sciences and Engineering, Michigan State 
      University, East Lansing, MI 48823, USA.
FAU - Sakamoto, Jeff
AU  - Sakamoto J
AD  - University of Michigan, Department of Mechanical Engineering, Ann Arbor, MI 
      48109, USA. Electronic address: jeffsaka@umich.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181217
PL  - Netherlands
TA  - J Mech Behav Biomed Mater
JT  - Journal of the mechanical behavior of biomedical materials
JID - 101322406
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polyesters)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 24980-41-4 (polycaprolactone)
RN  - 459TN2L5F5 (poly(lactide))
SB  - IM
MH  - Biocompatible Materials/*chemistry/*pharmacology
MH  - Humans
MH  - *Mechanical Phenomena
MH  - Nerve Regeneration/*drug effects
MH  - Peripheral Nerve Injuries/physiopathology
MH  - Polyesters/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer/chemistry
MH  - Porosity
MH  - Tissue Scaffolds/chemistry
OTO - NOTNLM
OT  - Bending
OT  - Compression
OT  - Multichannel scaffold
OT  - Nerve repair
OT  - Scale-up
EDAT- 2019/01/01 06:00
MHDA- 2020/07/01 06:00
CRDT- 2019/01/01 06:00
PHST- 2018/10/11 00:00 [received]
PHST- 2018/12/13 00:00 [revised]
PHST- 2018/12/16 00:00 [accepted]
PHST- 2019/01/01 06:00 [pubmed]
PHST- 2020/07/01 06:00 [medline]
PHST- 2019/01/01 06:00 [entrez]
AID - S1751-6161(18)31470-X [pii]
AID - 10.1016/j.jmbbm.2018.12.016 [doi]
PST - ppublish
SO  - J Mech Behav Biomed Mater. 2019 Mar;91:247-254. doi: 10.1016/j.jmbbm.2018.12.016. 
      Epub 2018 Dec 17.