PMID- 3059797
OWN - NLM
STAT- MEDLINE
DCOM- 19890125
LR  - 20190626
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 85
IP  - 6A
DP  - 1988 Dec 23
TI  - Genetic susceptibility to rheumatoid arthritis and human leukocyte antigen class 
      II polymorphism. The role of shared conformational determinants.
PG  - 17-9
AB  - Genetic susceptibility for rheumatoid arthritis has been associated with both 
      human leukocyte antigen (HLA)-DR4 and HLA-DR1, depending on the ethnic origin of 
      the population under study. Furthermore, various subtypes of DR4 exist, only some 
      of which appear to be associated with rheumatoid arthritis. DNA sequence analysis 
      of the DR-beta chain genes encoding the DR4 subtypes as well as DR1 has led to 
      the observation that similar third hypervariable region sequences are found on 
      rheumatoid arthritis-associated DR-beta chain alleles. The data indicate that 
      third hypervariable region sequence polymorphisms strongly influence T cell 
      recognition as well as risk for rheumatoid arthritis. This has led to the 
      hypothesis that genetic susceptibility for rheumatoid arthritis is due to a group 
      of similar third hypervariable region sequences that may share conformational 
      determinants important in antigen presentation and/or immune regulation.
FAU - Gregersen, P K
AU  - Gregersen PK
AD  - Department of Rheumatic Disease, Hospital for Joint Disease, New York, New York 
      10019.
FAU - Silver, J
AU  - Silver J
FAU - Winchester, R J
AU  - Winchester RJ
LA  - eng
GR  - AI19411/AI/NIAID NIH HHS/United States
GR  - AI22005/AI/NIAID NIH HHS/United States
GR  - AM33404/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Amino Acids)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Alleles
MH  - Amino Acids/analysis
MH  - Arthritis, Rheumatoid/*genetics
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - *Polymorphism, Genetic
MH  - Receptors, Antigen, T-Cell/genetics
RF  - 30
EDAT- 1988/12/23 00:00
MHDA- 1988/12/23 00:01
CRDT- 1988/12/23 00:00
PHST- 1988/12/23 00:00 [pubmed]
PHST- 1988/12/23 00:01 [medline]
PHST- 1988/12/23 00:00 [entrez]
AID - 10.1016/0002-9343(88)90374-9 [doi]
PST - ppublish
SO  - Am J Med. 1988 Dec 23;85(6A):17-9. doi: 10.1016/0002-9343(88)90374-9.