PMID- 30599080
OWN - NLM
STAT- MEDLINE
DCOM- 20190715
LR  - 20220408
IS  - 1095-8355 (Electronic)
IS  - 1065-6995 (Linking)
VI  - 43
IP  - 4
DP  - 2019 Apr
TI  - LncRNA MAFG-AS1 facilitates the migration and invasion of NSCLC cell via sponging 
      miR-339-5p from MMP15.
PG  - 384-393
LID - 10.1002/cbin.11092 [doi]
AB  - Non-small-cell carcinoma (NSCLC) is the most common cancer along with high 
      mortality rate worldwide. In the present study, our data showed that lncRNA MAF 
      BZIP Transcription Factor G Antisense RNA 1 (MAFG-AS1) was over-expressed in 
      NSCLC tissues and cell lines. Overexpression of MAFG-AS1 promoted the migration, 
      invasion and enhanced epithelial-mesenchymal transition (EMT) of NSCLC cell. In 
      addition, miR-339-5p was predicted to be a target of MAFG-AS1 and the level of 
      miR-339-5p was down-regulated in NSCLC. Over-expression of MAFG-AS1 significantly 
      decreased the level of miR-339-5p in NSCLC cell. Moreover, the matrix 
      metalloproteinase 15 (MMP15) was identified to be a target of miR-339-5p. The 
      level of MMP15 was negatively regulated by miR-339-5p whereas positively 
      controlled by MAFG-AS1. In addition, up-regulation of miR-339-5p neutralized the 
      promoting impact of MAFG-AS1 on the migration, invasion and EMT of NSCLC cell. 
      Finally, the xenograft model suggested that MAFG-AS1 promoted the metastasis of 
      NSCLC cell in vivo. Altogether, we proved that MAFG-AS1-miR-339-5p-MMP15 axis 
      might be a promising therapeutic target for the treatment of patients with NSCLC.
CI  - (c) 2019 International Federation for Cell Biology.
FAU - Jia, You Chao
AU  - Jia YC
AD  - Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Department of 
      Medical Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, 
      China.
FAU - Wang, Jian Yi
AU  - Wang JY
AD  - Hebei University, Baoding, Hebei 071000, China.
FAU - Liu, Yu Ying
AU  - Liu YY
AD  - Department of Oncology, Dezhou People's Hospital, Dezhou, Shandong, 253014, 
      China.
FAU - Li, Bin
AU  - Li B
AD  - Thoracic surgery, Dezhou People's Hospital, Dezhou, Shandong, 253014, China.
FAU - Guo, Hui
AU  - Guo H
AD  - Pneumology Department, Dezhou People's Hospital, No. 1751 Xinhu Street, Dezhou, 
      Shandong, 253014, China.
FAU - Zang, Ai Min
AU  - Zang AM
AD  - Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Department of 
      Medical Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, 
      China.
LA  - eng
GR  - Dezhou People's Hospital/
PT  - Journal Article
DEP - 20190206
PL  - England
TA  - Cell Biol Int
JT  - Cell biology international
JID - 9307129
RN  - 0 (MAFG protein, human)
RN  - 0 (MIRN339 microRNA, human)
RN  - 0 (MMP15 protein, human)
RN  - 0 (MafG Transcription Factor)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Antisense)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Repressor Proteins)
RN  - EC 3.4.24.- (Matrix Metalloproteinase 15)
SB  - IM
MH  - Animals
MH  - Carcinoma, Non-Small-Cell Lung/*genetics/metabolism/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Epithelial-Mesenchymal Transition/genetics
MH  - Heterografts
MH  - Humans
MH  - Lung Neoplasms/*genetics/metabolism/pathology
MH  - MafG Transcription Factor/genetics/metabolism
MH  - Matrix Metalloproteinase 15/genetics/*metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - MicroRNAs/genetics/*metabolism
MH  - Neoplasm Invasiveness
MH  - RNA, Antisense/genetics/*metabolism
MH  - RNA, Long Noncoding/genetics/metabolism
MH  - Repressor Proteins/genetics/metabolism
OTO - NOTNLM
OT  - EMT
OT  - MAFG-AS1
OT  - MiR-339-5p
OT  - NSCLC
OT  - growth
OT  - invasion
EDAT- 2019/01/02 06:00
MHDA- 2019/07/16 06:00
CRDT- 2019/01/02 06:00
PHST- 2018/08/02 00:00 [received]
PHST- 2018/12/21 00:00 [accepted]
PHST- 2019/01/02 06:00 [pubmed]
PHST- 2019/07/16 06:00 [medline]
PHST- 2019/01/02 06:00 [entrez]
AID - 10.1002/cbin.11092 [doi]
PST - ppublish
SO  - Cell Biol Int. 2019 Apr;43(4):384-393. doi: 10.1002/cbin.11092. Epub 2019 Feb 6.