PMID- 30599270 OWN - NLM STAT- MEDLINE DCOM- 20190621 LR - 20190621 IS - 1873-7544 (Electronic) IS - 0306-4522 (Linking) VI - 400 DP - 2019 Feb 21 TI - Intrauterine Growth Restriction Modifies the Accumbal Dopaminergic Response to Palatable Food Intake. PG - 184-195 LID - S0306-4522(18)30854-6 [pii] LID - 10.1016/j.neuroscience.2018.12.036 [doi] AB - Intrauterine growth restriction (IUGR) associates with increased preference for palatable foods and altered insulin sensitivity. Insulin modulates the central dopaminergic response and changes behavioral responses to reward. We measured the release of dopamine in the accumbens during palatable food intake in IUGR rats both at baseline and in response to insulin. From pregnancy day 10 until birth, gestating Sprague-Dawley rats received either an ad libitum (Control), or a 50% food restricted (FR) diet. In adulthood, palatable food consumption and feeding behavior entropy was assessed using an electronic food intake monitor (BioDAQ(R)), and dopamine response to palatable food was measured by chronoamperometry recordings in the nucleus accumbens (NAcc). FR rats eat more palatable foods during the dark phase, and their eating pattern has a higher entropy compared to control rats. There was a delayed dopamine release in the FR group in response to palatable food and insulin administration reverted this delayed effect. Western blot showed a decrease in suppressor of cytokine signaling 3 protein (SOCS3) in the ventral tegmental area (VTA) and an increase in the ratio of phospho-tyrosine hydroxylase to tyrosine hydroxylase (pTH/TH) in the NAcc of FR rats. Administration of insulin also abolished this latter effect in FR rats. FR rats showed metabolic alterations and a delay in the dopaminergic response to palatable foods. This could explain the increased palatable food intake and behavioral entropy found in FR rats. IUGR may lead to binge eating, obesity and its metabolic consequences by modifying the central dopaminergic response to sweet food. CI - Copyright (c) 2018 IBRO. Published by Elsevier Ltd. All rights reserved. FAU - Laureano, D P AU - Laureano DP AD - Programa de Pos Graduacao em Neurociencias, Instituto de Ciencias Basicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: dlaureano@hcpa.edu.br. FAU - Alves, M B AU - Alves MB AD - Programa de Pos Graduacao em Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Miguel, P M AU - Miguel PM AD - Programa de Pos Graduacao em Neurociencias, Instituto de Ciencias Basicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Machado, T D AU - Machado TD AD - Programa de Pos Graduacao em Saude da Crianca e do Adolescente, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Reis, A R AU - Reis AR AD - Programa de Pos Graduacao em Saude da Crianca e do Adolescente, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Mucellini, A B AU - Mucellini AB AD - Programa de Pos Graduacao em Psiquiatria, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Cunha, F S AU - Cunha FS AD - Programa de Pos Graduacao em Saude da Crianca e do Adolescente, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Lampert, C AU - Lampert C AD - Programa de Pos Graduacao em Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Salvador, A P A AU - Salvador APA AD - Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Dalle Molle, R AU - Dalle Molle R AD - Programa de Pos Graduacao em Saude da Crianca e do Adolescente, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Mosca, P R AU - Mosca PR AD - Programa de Pos Graduacao em Saude da Crianca e do Adolescente, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Pokhvisneva, I AU - Pokhvisneva I AD - Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada. FAU - Desai, M AU - Desai M AD - Dept of Ob/Gyn, Harbor-UCLA Med Ctr, Torrance, CA, United States. FAU - Ross, M G AU - Ross MG AD - Dept of Ob/Gyn, Harbor-UCLA Med Ctr, Torrance, CA, United States. FAU - Silveira, P P AU - Silveira PP AD - Programa de Pos Graduacao em Neurociencias, Instituto de Ciencias Basicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada; Department of Psychiatry, Faculty of Medicine, McGill University, Sackler Program for Epigenetics & Psychobiology at McGill University, Montreal, QC, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20181230 PL - United States TA - Neuroscience JT - Neuroscience JID - 7605074 RN - 0 (Insulin) RN - 0 (Socs3 protein, rat) RN - 0 (Suppressor of Cytokine Signaling 3 Protein) RN - EC 1.14.16.2 (Tyrosine 3-Monooxygenase) RN - VTD58H1Z2X (Dopamine) SB - IM MH - Animals MH - Dopamine/*metabolism MH - *Eating MH - Feeding Behavior MH - Female MH - Fetal Growth Retardation/*metabolism MH - Food Deprivation/physiology MH - Insulin/administration & dosage/*metabolism MH - Male MH - Nucleus Accumbens/*metabolism MH - Rats, Sprague-Dawley MH - Suppressor of Cytokine Signaling 3 Protein/metabolism MH - Tyrosine 3-Monooxygenase/metabolism MH - Ventral Tegmental Area/metabolism OTO - NOTNLM OT - dopamine OT - insulin OT - reward EDAT- 2019/01/02 06:00 MHDA- 2019/06/22 06:00 CRDT- 2019/01/02 06:00 PHST- 2018/08/03 00:00 [received] PHST- 2018/12/19 00:00 [revised] PHST- 2018/12/20 00:00 [accepted] PHST- 2019/01/02 06:00 [pubmed] PHST- 2019/06/22 06:00 [medline] PHST- 2019/01/02 06:00 [entrez] AID - S0306-4522(18)30854-6 [pii] AID - 10.1016/j.neuroscience.2018.12.036 [doi] PST - ppublish SO - Neuroscience. 2019 Feb 21;400:184-195. doi: 10.1016/j.neuroscience.2018.12.036. Epub 2018 Dec 30.