PMID- 30599396
OWN - NLM
STAT- MEDLINE
DCOM- 20190315
LR  - 20221207
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Linking)
VI  - 65
DP  - 2019 Feb
TI  - Association between HLA-A*3201 allele and oxcarbazepine-induced cutaneous adverse 
      reactions in Eastern Han Chinese population.
PG  - 25-30
LID - S1059-1311(18)30516-8 [pii]
LID - 10.1016/j.seizure.2018.12.011 [doi]
AB  - PURPOSE: To determine genetic associations between oxcarbazepine (OXC)-induced 
      cutaneous adverse drug reactions (cADRs) and human leukocyte antigen (HLA) 
      variants in the Eastern Han Chinese population. METHODS: A total of 120 patients 
      were enrolled in this study, including 30 subjects with OXC-induced cADRs (case 
      group) and 90 OXC-tolerant patients (control group). High-resolution HLA 
      genotyping was conducted for HLA-A, HLA-B, HLA-C, and HLA-DRB1, and allele 
      frequencies were compared. RESULTS: No patient carried the HLA-B *1502 allele in 
      the case group, the frequency of HLA-B *1502 allele in the control group was 
      6.1%. HLA-A*3201 allele was detected in 13.3% of 30 patients with OXC-induced 
      cADRs (4/30) and 0% of 90 OXC-tolerant patients (0/90). The difference in 
      HLA-A*3201 frequency between the two groups was statistically significant 
      [P = 0.004, odds ratio (OR) = 15.877, 95% confidence interval 
      (CI) = 1.817-138.720]. CONCLUSIONS: Eastern Han Chinese patients with the 
      HLA-A*3201 allele may be more susceptible to OXC-induced cADRs, while the 
      HLA-B*1502 allele is not correlated with it. The precise association between HLA 
      alleles and OXC-induced cADRs warrants further study.
CI  - Copyright (c) 2018 British Epilepsy Association. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Xu, Jianyang
AU  - Xu J
AD  - Department of Neurology & Institute of Neurology, Huai'an Third People's 
      Hospital, Jiangsu Province, China.
FAU - Shi, Xiangsong
AU  - Shi X
AD  - Department of Neurology & Institute of Neurology, Huai'an Third People's 
      Hospital, Jiangsu Province, China.
FAU - Qiu, Yinghui
AU  - Qiu Y
AD  - Department of Neurology & Institute of Neurology, Ruijin Hospital Affiliated to 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Zhang, Yadong
AU  - Zhang Y
AD  - Department of Neurology & Institute of Neurology, Huai'an Third People's 
      Hospital, Jiangsu Province, China.
FAU - Chen, Shengdi
AU  - Chen S
AD  - Department of Neurology & Institute of Neurology, Ruijin Hospital Affiliated to 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Shi, Yiwu
AU  - Shi Y
AD  - Institute of Neuroscience and Department of Neurology of Second, Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Deng, Yulei
AU  - Deng Y
AD  - Department of Neurology & Institute of Neurology, Ruijin Hospital Affiliated to 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic 
      address: dyl10786@rjh.com.cn.
LA  - eng
PT  - Journal Article
DEP - 20181218
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*32 antigen)
RN  - VZI5B1W380 (Oxcarbazepine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anticonvulsants/*adverse effects
MH  - Asian People/ethnology/genetics
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Epilepsy/*drug therapy/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - HLA-A Antigens/*genetics/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxcarbazepine/*adverse effects
MH  - Skin Diseases/*chemically induced/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Cutaneous adverse drug reactions
OT  - Epilepsy
OT  - HLA-A*3201
OT  - Oxcarbazepine
EDAT- 2019/01/02 06:00
MHDA- 2019/03/16 06:00
CRDT- 2019/01/02 06:00
PHST- 2018/08/16 00:00 [received]
PHST- 2018/12/02 00:00 [revised]
PHST- 2018/12/17 00:00 [accepted]
PHST- 2019/01/02 06:00 [pubmed]
PHST- 2019/03/16 06:00 [medline]
PHST- 2019/01/02 06:00 [entrez]
AID - S1059-1311(18)30516-8 [pii]
AID - 10.1016/j.seizure.2018.12.011 [doi]
PST - ppublish
SO  - Seizure. 2019 Feb;65:25-30. doi: 10.1016/j.seizure.2018.12.011. Epub 2018 Dec 18.