PMID- 30600287
OWN - NLM
STAT- MEDLINE
DCOM- 20190422
LR  - 20210928
IS  - 1665-2681 (Print)
IS  - 1665-2681 (Linking)
VI  - 17
IP  - 6
DP  - 2018 Oct 16
TI  - Effect of Proton Pump Inhibitors on Mortality in Patients with Cirrhosis and 
      Spontaneous Bacterial Peritonitis.
PG  - 933-939
LID - 10.5604/01.3001.0012.7193 [doi]
AB  - INTRODUCTION AND AIM: Spontaneous bacterial peritonitis (SBP) is a 
      life-threatening infection in patients with cirrhosis. However, it is unknown 
      whether patients with SBP and cirrhosis who do not have active gastrointestinal 
      bleeding have a poorer prognosis if treated with proton pump inhibitors (PPI). 
      MATERIAL AND METHODS: We used the Taiwan National Health Insurance Database to 
      identify 858 patients with SBP and cirrhosis who were administered PPIs and 
      hospitalized between January 1, 2010, and December 31, 2013. One-to-two 
      propensity score matching was performed to select a comparison group based on 
      age, gender, and comorbidities. All patients obtained follow-up for 1 year. 
      RESULTS: The overall 30-day, 90-day, and 1-year mortality was 27.9%, 49.0%, and 
      73.7%, respectively, in the PPI group and 25.6%, 43.8%, and 67.2%, respectively, 
      in the non-PPI group. After adjusting the Cox regression model for age, gender, 
      and comorbidities, the hazard ratios for PPIs regarding 30-day, 30- to 90-day, 
      and 90-day to 1-year mortality were 1.074 (95% CI 0.917-1.257, P = 0.377), 1.390 
      (95% CI 1.154-1.673, P = 0.001), and 1.297 (95% CI 1.099- 1.531, P = 0.002), 
      respectively. CONCLUSIONS: PPIs did not increase the short-term mortality of 
      patients with SBP and cirrosis who did not have active gastrointestinal bleeding, 
      but PPIs increased the long-term mortality risk. For these patients, physicians 
      should discontinue PPIs as early as possible.
FAU - Hung, Tsung-Hsing
AU  - Hung TH
AD  - Division of Gastroenterology. Department of Medicine, Dalin Tzu Chi Hospital, 
      Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
FAU - Tseng, Chih-Wei
AU  - Tseng CW
AD  - Division of Gastroenterology. Department of Medicine, Dalin Tzu Chi Hospital, 
      Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
FAU - Lee, Hsing-Feng
AU  - Lee HF
AD  - Division of Gastroenterology. Department of Medicine, Dalin Tzu Chi Hospital, 
      Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
FAU - Tsai, Chih-Chun
AU  - Tsai CC
AD  - Department of Mathematics, Tamkang University, Tamsui, Taiwan.
FAU - Tsai, Chen-Chi
AU  - Tsai CC
AD  - School of Medicine, Tzu Chi University, Hualien, Taiwan.
LA  - eng
PT  - Journal Article
PL  - Mexico
TA  - Ann Hepatol
JT  - Annals of hepatology
JID - 101155885
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Bacterial Infections/diagnosis/microbiology/*mortality
MH  - Databases, Factual
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - Liver Cirrhosis/diagnosis/*drug therapy/microbiology/*mortality
MH  - Male
MH  - Middle Aged
MH  - Peritonitis/diagnosis/microbiology/*mortality
MH  - Proton Pump Inhibitors/administration & dosage/*adverse effects
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Taiwan
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cirrhosis
OT  - Mortality
OT  - Proton pump inhibitor
OT  - Spontaneous bacterial peritonitis
EDAT- 2019/01/03 06:00
MHDA- 2019/04/23 06:00
CRDT- 2019/01/03 06:00
PHST- 2019/01/03 06:00 [entrez]
PHST- 2019/01/03 06:00 [pubmed]
PHST- 2019/04/23 06:00 [medline]
AID - S1665-2681(19)31055-5 [pii]
AID - 10.5604/01.3001.0012.7193 [doi]
PST - ppublish
SO  - Ann Hepatol. 2018 Oct 16;17(6):933-939. doi: 10.5604/01.3001.0012.7193.