PMID- 30600659
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2093-2340 (Print)
IS  - 2092-6448 (Electronic)
IS  - 1598-8112 (Linking)
VI  - 50
IP  - 4
DP  - 2018 Dec
TI  - Mycobacterium avium Complex Infection-Related Immune Reconstitution Inflammatory 
      Syndrome Mimicking Lymphoma in an Human Immunodeficiency Virus-Infected Patient.
PG  - 350-356
LID - 10.3947/ic.2018.50.4.350 [doi]
AB  - In acquired immunodeficiency syndrome (AIDS) patients, immune reconstitution 
      inflammatory syndrome (IRIS) due to Mycobacterium avium complex (MAC) infection 
      is one of the most difficult IRIS types to manage. We report an unusual case of 
      MAC-associated IRIS. At first the patient was diagnosed human immunodeficiency 
      virus (HIV) infection after he was admitted with pneumocystis pneumonia. After 
      starting antiretroviral therapy he presented unmasked IRIS with MAC infection. 
      Next, he was hospitalized with continuous loose stools and new-onset fever. 
      Investigation included computed tomography (CT), which showed homogeneous 
      enhancement and enlargement of the lymph nodes (LN), elevation of ferritin 
      (>1,650 ng/mL) and lactate dehydrogenase (306 IU/L) levels, and F- 
      fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) 
      scan, which showed increased FDG uptake. These findings were highly indicative of 
      lymphoma. We performed laparoscopic biopsy of the mesenteric LN, and the biopsy 
      culture grew MAC. So we made a diagnosis of MAC-associated. Therefore, IRIS must 
      be considered as a possible diagnosis when AIDS patients develop new symptoms or 
      exhibit exacerbations of existing symptoms. Furthermore the biopsies should be 
      conducted.
CI  - Copyright (c) 2018 by The Korean Society of Infectious Diseases and Korean Society 
      for Chemotherapy.
FAU - Sohn, Sungmin
AU  - Sohn S
AUID- ORCID: 0000-0003-2402-7585
AD  - Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym 
      University Medical College, Seoul, Korea.
FAU - Shi, Hye Jin
AU  - Shi HJ
AD  - Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym 
      University Medical College, Seoul, Korea.
FAU - Wang, Sung Ho
AU  - Wang SH
AD  - Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym 
      University Medical College, Seoul, Korea.
FAU - Lee, Sang Ki
AU  - Lee SK
AD  - Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym 
      University Medical College, Seoul, Korea.
FAU - Park, So Yeon
AU  - Park SY
AUID- ORCID: 0000-0002-5318-8305
AD  - Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym 
      University Medical College, Seoul, Korea.
FAU - Lee, Jin Seo
AU  - Lee JS
AUID- ORCID: 0000-0003-3913-6370
AD  - Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym 
      University Medical College, Seoul, Korea.
FAU - Eom, Joong Sik
AU  - Eom JS
AUID- ORCID: 0000-0003-2744-1159
AD  - Division of Infectious Diseases, Department of Internal Medicine, Gil Medical 
      Center, Gachon University College of Medicine, Incheon, Korea. 
      helppl@gachon.ac.kr.
LA  - eng
PT  - Case Reports
PL  - Korea (South)
TA  - Infect Chemother
JT  - Infection & chemotherapy
JID - 101531537
PMC - PMC6312901
OTO - NOTNLM
OT  - Acquired immunodeficiency syndrome
OT  - Lymphoma
OT  - Mycobacterium avium complex
COIS- No conflicts of interest.
EDAT- 2019/01/03 06:00
MHDA- 2019/01/03 06:01
PMCR- 2018/12/01
CRDT- 2019/01/03 06:00
PHST- 2017/07/13 00:00 [received]
PHST- 2017/12/15 00:00 [accepted]
PHST- 2019/01/03 06:00 [entrez]
PHST- 2019/01/03 06:00 [pubmed]
PHST- 2019/01/03 06:01 [medline]
PHST- 2018/12/01 00:00 [pmc-release]
AID - 50.350 [pii]
AID - 10.3947/ic.2018.50.4.350 [doi]
PST - ppublish
SO  - Infect Chemother. 2018 Dec;50(4):350-356. doi: 10.3947/ic.2018.50.4.350.