PMID- 30601191
OWN - NLM
STAT- MEDLINE
DCOM- 20190506
LR  - 20190506
IS  - 1558-2035 (Electronic)
IS  - 1558-2027 (Linking)
VI  - 20
IP  - 3
DP  - 2019 Mar
TI  - Stent malapposition, strut coverage and atherothrombotic prolapse after 
      percutaneous coronary interventions in ST-segment elevation myocardial 
      infarction.
PG  - 122-130
LID - 10.2459/JCM.0000000000000749 [doi]
AB  - AIMS: Stent implantation in ST-segment elevation myocardial infarction (STEMI) 
      patients can be challenging and sometimes associated with immediate and long-term 
      suboptimal results. Stent malapposition and strut uncoverage, predictors of stent 
      thrombosis, are frequently detected in STEMI patients at medium/long-term 
      follow-up. Nevertheless, data at a short follow-up are missing. We aimed to 
      assess the extent of stent malapposition and struts coverage in the subacute 
      phase of STEMI after stent implantation in primary or rescue percutaneous 
      coronary intervention (PCI). METHODS: STEMI patients undergone primary or rescue 
      PCI and scheduled for a second coronary angiography after 2-7 days were enrolled. 
      During the second procedure, frequency domain optical coherence tomography 
      (FD-OCT) was performed to assess percentage of malapposed struts (MS%), 
      percentage area of malapposition (MA%), percentage of uncovered struts (US%), 
      percentage area of atherothrombotic prolapse (PA%) and optical coherence 
      tomography thrombus score (OCT-TS). RESULTS: Twenty patients were included and 21 
      stents (19 865 struts) were evaluated. Strut uncoverage was relatively limited 
      [US% = 11.1 (8.1-13.6) %]. Stent malapposition was observed frequently, even if 
      at low degree [MS% = 6.4 (3.3-13.3) %, MA% = 1.80 (0.46-2.76) %] as well as 
      atherothrombotic prolapse [PA% = 0.09 (0.00-1.06) %]. Both MA% and PA% were 
      significantly related to residual OCT-TS (R = -0.52, P = 0.02 and R = 0.71, 
      P < 0.001, respectively), use of thrombolysis (P = 0.001 and P = 0.004, 
      respectively) and time elapsed from PCI to FD-OCT analysis (P = 0.001). 
      CONCLUSION: In the subacute phase after stenting in STEMI patients, strut 
      uncoverage is relatively limited, while stent malapposition and atherothrombotic 
      prolapse are common albeit limited features. Residual thrombus burden influences 
      the degree of both stent malapposition and atherothrombotic prolapse.
FAU - Leone, Antonio Maria
AU  - Leone AM
AD  - Fondazione Policlinico Universitario A. Gemelli IRCCS.
FAU - Rebuzzi, Antonio Giuseppe
AU  - Rebuzzi AG
AD  - Fondazione Policlinico Universitario A. Gemelli IRCCS.
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - Burzotta, Francesco
AU  - Burzotta F
AD  - Fondazione Policlinico Universitario A. Gemelli IRCCS.
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - De Maria, Giovanni Luigi
AU  - De Maria GL
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - Gardi, Andrea
AU  - Gardi A
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - Basile, Eloisa
AU  - Basile E
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - Cialdella, Pio
AU  - Cialdella P
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - D'Amario, Domenico
AU  - D'Amario D
AD  - Fondazione Policlinico Universitario A. Gemelli IRCCS.
FAU - Paraggio, Lazzaro
AU  - Paraggio L
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - Porto, Italo
AU  - Porto I
AD  - Fondazione Policlinico Universitario A. Gemelli IRCCS.
FAU - Aurigemma, Cristina
AU  - Aurigemma C
AD  - Fondazione Policlinico Universitario A. Gemelli IRCCS.
FAU - Niccoli, Giampaolo
AU  - Niccoli G
AD  - Fondazione Policlinico Universitario A. Gemelli IRCCS.
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - Trani, Carlo
AU  - Trani C
AD  - Fondazione Policlinico Universitario A. Gemelli IRCCS.
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - Crea, Filippo
AU  - Crea F
AD  - Fondazione Policlinico Universitario A. Gemelli IRCCS.
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - J Cardiovasc Med (Hagerstown)
JT  - Journal of cardiovascular medicine (Hagerstown, Md.)
JID - 101259752
SB  - IM
MH  - Aged
MH  - Coronary Angiography
MH  - Coronary Artery Disease/diagnostic imaging/*surgery
MH  - Coronary Thrombosis/diagnostic imaging/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention/*adverse effects/*instrumentation
MH  - Prospective Studies
MH  - Prosthesis Design
MH  - Risk Factors
MH  - ST Elevation Myocardial Infarction/diagnostic imaging/*surgery
MH  - *Stents
MH  - Time Factors
MH  - Tomography, Optical Coherence
MH  - Treatment Outcome
EDAT- 2019/01/03 06:00
MHDA- 2019/05/07 06:00
CRDT- 2019/01/03 06:00
PHST- 2019/01/03 06:00 [pubmed]
PHST- 2019/05/07 06:00 [medline]
PHST- 2019/01/03 06:00 [entrez]
AID - 10.2459/JCM.0000000000000749 [doi]
PST - ppublish
SO  - J Cardiovasc Med (Hagerstown). 2019 Mar;20(3):122-130. doi: 
      10.2459/JCM.0000000000000749.