PMID- 30601367
OWN - NLM
STAT- MEDLINE
DCOM- 20200824
LR  - 20200824
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 68
IP  - 5
DP  - 2019 May
TI  - Celiac Disease in Brazilian First-degree Relatives: The Odds Are Five Times 
      Greater for HLA DQ2 Homozygous.
PG  - e77-e80
LID - 10.1097/MPG.0000000000002251 [doi]
AB  - First-degree relatives (FDRs) of 47 outpatients with celiac disease (CD) answered 
      a questionnaire about symptoms related to CD and were investigated for human 
      leukocyte antigen (HLA)-DQ2, DQB102 homozygosis, and DQ8 alleles. Genetically 
      susceptible individuals were tested for antitransglutaminase antibody 
      immunoglobulin A. Seropositive FDR underwent small bowel biopsies.From 114 FDR, 
      74.5% (n = 85) were positive for DQ2, DQ8, or both haplotypes. Homozygosity of 
      DQB102 was found in 11.4% (n = 13) individuals. Three FDR were previously 
      diagnosed with CD. Among the genetically susceptible individuals, 67.1% had at 
      least 1 symptom related to CD. Seropositivity was 8/82 (9.8%), and 4/8 biopsies 
      were compatible with CD. Therefore, the total number of FDR with CD was 6.1% 
      (7/114), 95% confidence interval (1.71, 10.49). Three out of 7 FDR with CD were 
      HLA DQB102 homozygous. The odds of being CD is 5 times, 95% confidence interval 
      (0.99, 26.23), greater for HLA DQ B102 homozygous in FDR.
FAU - Lopes, Leticia H C
AU  - Lopes LHC
AD  - Division of Pediatric Gastroenterology, Pediatric Department, Escola Paulista de 
      Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
FAU - Muniz, Janaina G
AU  - Muniz JG
FAU - Oliveira, Ricardo P
AU  - Oliveira RP
FAU - Sdepanian, Vera L
AU  - Sdepanian VL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
CIN - J Pediatr Gastroenterol Nutr. 2019 Nov;69(5):e148-e149. PMID: 31425368
CIN - J Pediatr Gastroenterol Nutr. 2019 Nov;69(5):e149. PMID: 31425369
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Biopsy
MH  - Brazil
MH  - Celiac Disease/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Testing
MH  - HLA-DQ Antigens/*blood
MH  - HLA-DQ beta-Chains/*blood
MH  - Homozygote
MH  - Humans
MH  - Infant
MH  - Intestine, Small/pathology
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Pedigree
MH  - Young Adult
EDAT- 2019/01/03 06:00
MHDA- 2020/08/25 06:00
CRDT- 2019/01/03 06:00
PHST- 2019/01/03 06:00 [pubmed]
PHST- 2020/08/25 06:00 [medline]
PHST- 2019/01/03 06:00 [entrez]
AID - 10.1097/MPG.0000000000002251 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2019 May;68(5):e77-e80. doi: 
      10.1097/MPG.0000000000002251.