PMID- 30602214
OWN - NLM
STAT- MEDLINE
DCOM- 20191023
LR  - 20191023
IS  - 0002-5151 (Print)
IS  - 0002-5151 (Linking)
VI  - 65
IP  - 4
DP  - 2018 Oct-Dec
TI  - [Chlorhexidine anaphylaxis in a perioperative context: diagnosis and management].
PG  - 431-436
LID - 10.29262/ram.v65i4.347 [doi]
AB  - BACKGROUND: During surgery, the patient is exposed to multiple medications and 
      molecules that can be associated with the development hypersensitivity, which 
      makes it difficult to detect the causative agent of a perioperative reaction and 
      makes it necessary to perform allergy tests. CASE REPORT: 53-year-old man who 
      after a right knee arthroscopy was administered intravenous ketorolac; at 12 
      minutes, a pruriginous rash appeared on the chest, abdomen and limbs; infusion of 
      the drug was immediately stopped and 100 mg intravenous hydrocortisone were 
      administered. At 15 minutes, the patient experienced bilateral angioedema of the 
      eyelids and a sensation of breathlessness, and oxygen was therefore administered, 
      as well as 2 mg intravenous clemastine, 5 mg intravenous ranitidine and 20 microg 
      subcutaneous adrenaline. Epidermal tests with 0.5 % chlorhexidine and serum 
      chlorhexidine-specific immunoglobulin E (IgE) were performed, both with positive 
      results. The patient recovered without complications; at discharge, he was 
      prescribed intramuscular etofenamate. CONCLUSION: Perioperative anaphylaxis is a 
      rare, but potentially fatal event. Proper identification of the drug or substance 
      responsible for the reaction by using allergy tests decreases unnecessary 
      pharmacological restrictions and avoids re-exposure.
FAU - Calle, Ana
AU  - Calle A
AD  - Universidad de Antioquia, Grupo de Alergologia Clinica y Experimental, Medellin, 
      Colombia. anacalle77@gmail.com.
FAU - Guevara-Saldana, Liliana
AU  - Guevara-Saldana L
FAU - Cardona, Ricardo
AU  - Cardona R
LA  - spa
PT  - Case Reports
PT  - Journal Article
TT  - Anafilaxia por clorhexidina en un contexto perioperatorio: diagnostico y manejo.
PL  - Mexico
TA  - Rev Alerg Mex
JT  - Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
JID - 9438824
RN  - R4KO0DY52L (Chlorhexidine)
SB  - IM
MH  - Anaphylaxis/*chemically induced/diagnosis/drug therapy
MH  - Chlorhexidine/*adverse effects
MH  - Humans
MH  - Intraoperative Complications/*chemically induced/diagnosis/drug therapy
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Anaphylaxis
OT  - Chlorhexidine
OT  - Perioperative care
EDAT- 2019/01/03 06:00
MHDA- 2019/10/24 06:00
CRDT- 2019/01/03 06:00
PHST- 2019/01/03 06:00 [entrez]
PHST- 2019/01/03 06:00 [pubmed]
PHST- 2019/10/24 06:00 [medline]
AID - 10.29262/ram.v65i4.347 [doi]
PST - ppublish
SO  - Rev Alerg Mex. 2018 Oct-Dec;65(4):431-436. doi: 10.29262/ram.v65i4.347.