PMID- 30602395
OWN - NLM
STAT- MEDLINE
DCOM- 20191219
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 21
IP  - 1
DP  - 2019 Jan 3
TI  - Prognostic and functional implications of left atrial late gadolinium 
      enhancement cardiovascular magnetic resonance.
PG  - 2
LID - 10.1186/s12968-018-0514-3 [doi]
LID - 2
AB  - BACKGROUND: Left atrial (LA) late gadolinium enhancement (LGE) on cardiovascular 
      magnetic resonance (CMR) imaging is indicative of fibrosis, and has been 
      correlated with reduced LA function, increased LA volume, and poor procedural 
      outcomes in cohorts with atrial fibrillation (AF). However, the role of LGE as a 
      prognostic biomarker for arrhythmia in cardiac disease has not been examined. 
      METHODS: In this study, we assessed LA LGE using a 3D LGE CMR sequence to examine 
      its relationships with new onset atrial arrhythmia, and LA and left ventricular 
      (LV) mechanical function. RESULTS: LA LGE images were acquired in 111 patients 
      undergoing CMR imaging, including 66 patients with no prior history of an atrial 
      arrhythmia. During the median follow-up of 2.7 years (interquartile range (IQR) 
      1.8-3.7 years), 15/66 (23%) of patients developed a new atrial arrhythmia. LA LGE 
      >/=10% of LA myocardial volume was significantly associated with an increased rate 
      of new-onset atrial arrhythmia, with a hazard ratio of 3.16 (95% CI 1.14-8.72), 
      p = 0.026. There were significant relationships between LA LGE and both LA 
      ejection fraction (r = - 0.39, p < 0.0005) and echocardiographic LV septal e' 
      (r = - 0.24, p = 0.04) and septal E/e' (r = 0.31, p = 0.007). CONCLUSIONS: 
      Elevated LA LGE is associated with reduced LA function and reduced LV diastolic 
      function. LA LGE is associated with new onset atrial arrhythmia during follow-up.
FAU - Quail, Michael
AU  - Quail M
AD  - Department of Internal Medicine (Cardiology), Yale School of Medicine, 300 Cedar 
      St, New Haven, CT, 06520, USA.
AD  - Centre for Cardiovascular Imaging, Institute of Cardiovascular Science, 
      University College London, London, UK.
FAU - Grunseich, Karl
AU  - Grunseich K
AD  - Department of Radiology and Biomedical Imaging, Yale School of Medicine, New 
      Haven, CT, USA.
FAU - Baldassarre, Lauren A
AU  - Baldassarre LA
AD  - Department of Internal Medicine (Cardiology), Yale School of Medicine, 300 Cedar 
      St, New Haven, CT, 06520, USA.
AD  - Department of Radiology and Biomedical Imaging, Yale School of Medicine, New 
      Haven, CT, USA.
FAU - Mojibian, Hamid
AU  - Mojibian H
AD  - Department of Radiology and Biomedical Imaging, Yale School of Medicine, New 
      Haven, CT, USA.
FAU - Marieb, Mark A
AU  - Marieb MA
AD  - Department of Radiology and Biomedical Imaging, Yale School of Medicine, New 
      Haven, CT, USA.
FAU - Cornfeld, Daniel
AU  - Cornfeld D
AD  - Department of Radiology and Biomedical Imaging, Yale School of Medicine, New 
      Haven, CT, USA.
FAU - Soufer, Aaron
AU  - Soufer A
AD  - Department of Internal Medicine (Cardiology), Yale School of Medicine, 300 Cedar 
      St, New Haven, CT, 06520, USA.
FAU - Sinusas, Albert J
AU  - Sinusas AJ
AD  - Department of Internal Medicine (Cardiology), Yale School of Medicine, 300 Cedar 
      St, New Haven, CT, 06520, USA.
AD  - Department of Radiology and Biomedical Imaging, Yale School of Medicine, New 
      Haven, CT, USA.
FAU - Peters, Dana C
AU  - Peters DC
AD  - Department of Radiology and Biomedical Imaging, Yale School of Medicine, New 
      Haven, CT, USA. Dana.peters@yale.edu.
LA  - eng
GR  - FS/16/28/32327/BHF_/British Heart Foundation/United Kingdom
GR  - R01 HL122560/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190103
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Atrial Fibrillation/*diagnostic imaging/etiology/pathology/physiopathology
MH  - *Atrial Function, Left
MH  - *Atrial Remodeling
MH  - Contrast Media/*administration & dosage
MH  - Fibrosis
MH  - Heart Atria/*diagnostic imaging/pathology/physiopathology
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Organometallic Compounds/*administration & dosage
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Ventricular Function, Left
PMC - PMC6317232
OTO - NOTNLM
OT  - Atrial fibrillation
OT  - Cardiovascular magnetic resonance
OT  - Ejection fraction
OT  - Late gadolinium enhancement
OT  - Left atrium
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: This study was approved by the Yale 
      Medical School IRB as an exempt retrospective chart review study. CONSENT FOR 
      PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they 
      have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral 
      with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2019/01/04 06:00
MHDA- 2019/12/20 06:00
PMCR- 2019/01/03
CRDT- 2019/01/04 06:00
PHST- 2018/06/07 00:00 [received]
PHST- 2018/12/04 00:00 [accepted]
PHST- 2019/01/04 06:00 [entrez]
PHST- 2019/01/04 06:00 [pubmed]
PHST- 2019/12/20 06:00 [medline]
PHST- 2019/01/03 00:00 [pmc-release]
AID - S1097-6647(23)00175-8 [pii]
AID - 514 [pii]
AID - 10.1186/s12968-018-0514-3 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2019 Jan 3;21(1):2. doi: 10.1186/s12968-018-0514-3.