PMID- 30603003
OWN - NLM
STAT- MEDLINE
DCOM- 20190408
LR  - 20231005
IS  - 1729-0503 (Electronic)
IS  - 1680-6905 (Print)
IS  - 1680-6905 (Linking)
VI  - 18
IP  - 3
DP  - 2018 Sep
TI  - Thyroid profile and LDH Isoenzymes as prognostic biomarkers for diabetic and/or 
      obese subjects.
PG  - 697-706
LID - 10.4314/ahs.v18i3.28 [doi]
AB  - BACKGROUND: This study aimed to evaluate the levels of thyroid hormones and 
      lactate dehydrogenase (LDH) isoenzymes in obese and/or diabetic patients. 
      SUBJECTS AND METHODS: Forty male subjects categorized into four equal groups; 
      group 1: Non obese control subjects, group 2: Subjects suffering from type 2 
      diabetes mellitus (T2DM), group 3: Obese subjects (BMI >/= 30 kg/m(2)) and group 4: 
      Subjects thatwere obese and had type 2 diabetes mellitus (T2DM). Liver, kidney, 
      lipid, thyroid hormones, total LDH and LDH isoenzymes levels were determined. 
      RESULTS: There was a significant increase of TSH level (p<0.001) in diabetic 
      group as compared with control group and a highly significant increase of TSH was 
      obtained in obese and obese diabetic groups versus control and diabetic patients. 
      LDH 2 was also highly significantly decreased in obese and obese diabetic groups 
      versus diabetic patients. Percentage of LDH 4 was significantly decreased in both 
      diabetic and obese groups and not significantly changed in obese diabetic 
      patients as compared with the control group. LDH 5 percentage showed very highly 
      significant decrease in diabetic, obese and highly significant decrease in obese 
      diabetic groups when compared with control subjects while it was not 
      significantly changed in obese and obese diabetic groups as compared with 
      diabetic patients. CONCLUSION: LDH isozymes can be used as valuable diagnostic 
      markers for metabolic syndrome. This may help to explore the metabolic changes 
      associated with obesity and diabetes complication and following up the 
      complication of these abnormalities.
FAU - Johari, Turki Y
AU  - Johari TY
AD  - Department of Biochemistry, Faculty of Science, King Abdulaziz University, 
      Jeddah, Saudi Arabia.
FAU - Ghoneim, Magdy A
AU  - Ghoneim MA
AD  - Department of Biochemistry, Faculty of Science, King Abdulaziz University, 
      Jeddah, Saudi Arabia.
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, 
      Egypt.
FAU - Moselhy, Said S
AU  - Moselhy SS
AD  - Department of Biochemistry, Faculty of Science, King Abdulaziz University, 
      Jeddah, Saudi Arabia.
AD  - Department of Biochemistry, Faculty of Science, Ain Shams University, Egypt.
LA  - eng
PT  - Journal Article
PL  - Uganda
TA  - Afr Health Sci
JT  - African health sciences
JID - 101149451
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Isoenzymes)
RN  - 0 (Thyroid Hormones)
RN  - 9002-71-5 (Thyrotropin)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Type 2/*blood/complications/diagnosis
MH  - Humans
MH  - Isoenzymes/*blood
MH  - L-Lactate Dehydrogenase/*blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood/complications/diagnosis
MH  - Prognosis
MH  - Thyroid Hormones/*blood
MH  - Thyrotropin/blood
PMC - PMC6307009
OTO - NOTNLM
OT  - Thyroid profile
OT  - diabetes
OT  - lactate dehydrogenase
OT  - obesity
EDAT- 2019/01/04 06:00
MHDA- 2019/04/09 06:00
PMCR- 2018/09/01
CRDT- 2019/01/04 06:00
PHST- 2019/01/04 06:00 [entrez]
PHST- 2019/01/04 06:00 [pubmed]
PHST- 2019/04/09 06:00 [medline]
PHST- 2018/09/01 00:00 [pmc-release]
AID - jAFHS.v18.i3.pg697 [pii]
AID - 10.4314/ahs.v18i3.28 [doi]
PST - ppublish
SO  - Afr Health Sci. 2018 Sep;18(3):697-706. doi: 10.4314/ahs.v18i3.28.