PMID- 30603255
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231004
IS  - 2190-1678 (Print)
IS  - 2190-1686 (Electronic)
IS  - 2190-1678 (Linking)
VI  - 7
IP  - 2
DP  - 2016 Jun
TI  - Effect of cinnamon supplementation on glucose, lipids levels, glomerular 
      filtration rate, and blood pressure of subjects with type 2 diabetes mellitus.
PG  - 124-132
LID - 10.1007/s13340-015-0218-y [doi]
AB  - A randomized, double-blind, placebo-controlled trial was performed to investigate 
      the effect of cinnamon supplementation on glucose, triglyceride (TG), and high 
      density lipoprotein-cholesterol (HDL-C) levels, TG/HDL-C ratio, blood pressure 
      (BP), and estimated glomerular filtration rate (eGFR) for ninety-nine type 2 
      diabetes mellitus (T2DM) patients. Forty nine (49) patients with T2DM were in the 
      cinnamon group whereas 50 were in the placebo group. All participants received 
      either a cinnamon or placebo capsule daily for the 60-day study period. At the 
      end of the study, median glucose, TG, TG/HDL-C ratio, and BP were significantly 
      decreased (p < 0.005) whereas HDL-C and eGFR levels were significantly increased 
      (p < 0.005) in the cinnamon supplementation group. Interestingly, the study also 
      revealed reduction of HbA1c levels after the 60-day study period. In the placebo 
      group, glucose, TG levels tended to increase and HDL-C levels tended to decrease 
      whereas systolic and diastolic BP, HbA1c, and BUN CT were significantly increased 
      and eGFR was significantly reduced (p < 0.005). Cinnamon supplementation reduced 
      plasma glucose, HbA1c, triglyceride, TG/HDL-C ratio, and BP and increased HDL-C 
      levels and eGFR in subjects with T2DM. Cinnamon supplementation may be beneficial 
      for those with T2DM to prevent and control diabetic complications.
FAU - Sengsuk, Chintana
AU  - Sengsuk C
AD  - 1Chronic Diseases Research Unit, Department of Medical Technology, Faculty of 
      Allied Health Sciences, Naresuan University, Phitsanulok, 65000 Thailand. GRID: 
      grid.412029.c. ISNI: 0000000092112704
FAU - Sanguanwong, Sawitra
AU  - Sanguanwong S
AD  - Diabetes Care Clinic, Ladyao Hospital, Nakonsawan, 60000 Thailand.
FAU - Tangvarasittichai, Orathai
AU  - Tangvarasittichai O
AD  - 1Chronic Diseases Research Unit, Department of Medical Technology, Faculty of 
      Allied Health Sciences, Naresuan University, Phitsanulok, 65000 Thailand. GRID: 
      grid.412029.c. ISNI: 0000000092112704
FAU - Tangvarasittichai, Surapon
AU  - Tangvarasittichai S
AD  - 1Chronic Diseases Research Unit, Department of Medical Technology, Faculty of 
      Allied Health Sciences, Naresuan University, Phitsanulok, 65000 Thailand. GRID: 
      grid.412029.c. ISNI: 0000000092112704
LA  - eng
PT  - Journal Article
DEP - 20150709
PL  - Japan
TA  - Diabetol Int
JT  - Diabetology international
JID - 101553224
PMC - PMC6225001
OTO - NOTNLM
OT  - Blood pressure
OT  - Cinnamon
OT  - Estimated glomerular filtration rate
OT  - Glucose
OT  - TG/HDL-C ratio
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests.All procedures followed 
      were in accordance with the ethical standards of the responsible committee on 
      human experimentation (institutional and national) and with the Helsinki 
      Declaration of 1964 and later versions. Informed consent or a substitute for it 
      was obtained from all patients before inclusion in the study.
EDAT- 2015/07/09 00:00
MHDA- 2015/07/09 00:01
PMCR- 2016/07/09
CRDT- 2019/01/04 06:00
PHST- 2014/11/24 00:00 [received]
PHST- 2015/06/21 00:00 [accepted]
PHST- 2019/01/04 06:00 [entrez]
PHST- 2015/07/09 00:00 [pubmed]
PHST- 2015/07/09 00:01 [medline]
PHST- 2016/07/09 00:00 [pmc-release]
AID - 218 [pii]
AID - 10.1007/s13340-015-0218-y [doi]
PST - epublish
SO  - Diabetol Int. 2015 Jul 9;7(2):124-132. doi: 10.1007/s13340-015-0218-y. 
      eCollection 2016 Jun.