PMID- 30604399
OWN - NLM
STAT- MEDLINE
DCOM- 20190620
LR  - 20200309
IS  - 1179-2000 (Electronic)
IS  - 1177-1062 (Linking)
VI  - 23
IP  - 1
DP  - 2019 Feb
TI  - Integrated Interaction Network of MicroRNA Target Genes in Keloid Scarring.
PG  - 53-63
LID - 10.1007/s40291-018-0378-0 [doi]
AB  - Keloids are a common dermal pathological disorder characterized by the excessive 
      deposition of extracellular matrix components; however, the exact pathogenesis of 
      the disease is still not clear. Studies increasingly suggest that microRNAs 
      (miRNAs) can play a key role in the process of keloid scarring. In this study, 
      the valuable miRNAs and target genes were screened and the interaction network 
      was constructed. We also predicted target genes of reported miRNAs using 
      TargetScan and miRTarBase software. Cytoscape 3.0.1 further showed the 
      interaction network of miRNA and target genes. Among the various miRNAs involved 
      in keloid pathogenesis, miRNA-21, miRNA-141-3p, miRNA-181a, and miRNA-205 were 
      thought to up-regulate the proliferation and decrease apoptosis of keloid-derived 
      fibroblasts through the PI3K/Akt/mammalian target of rapamycin (mTOR) signaling 
      pathway. miRNA-637 and miRNA-1224 inhibited keloid fibroblasts proliferation and 
      promoted apoptosis via the transforming growth factor (TGF)-beta1/Smad3 signaling 
      pathway. miRNA-21 was also involved in mitochondrial-mediated apoptosis and 
      miRNA-31 targeted vascular endothelial growth factor (VEGF) signaling pathway. 
      miRNA-199a may be one key factor in the cell cycle checkpoint signal pathway of 
      keloid-derived fibroblasts. It was also found that miRNA-29a and miRNA-196a 
      mediated collagen metabolism. These pivotal miRNAs and regulatory processes 
      further improve the data on the epigenetic mechanisms of keloids and provide hope 
      for the use of small molecules in the treatment of keloids.
FAU - Lyu, Lechun
AU  - Lyu L
AD  - Technology Transfer Center, Kunming Medical University, 1168 West Chunrong Road, 
      Yuhua Avenue, Chenggong District, Kunming, 650500, Yunnan, China.
FAU - Zhao, Yu
AU  - Zhao Y
AD  - Biomedical Engineering Research Center, Kunming Medical University, 1168 West 
      Chunrong Road, Yuhua Avenue, Chenggong District, Kunming, 650500, Yunnan, China.
FAU - Lu, Hongquan
AU  - Lu H
AD  - Biomedical Engineering Research Center, Kunming Medical University, 1168 West 
      Chunrong Road, Yuhua Avenue, Chenggong District, Kunming, 650500, Yunnan, China.
FAU - Liu, Zijie
AU  - Liu Z
AD  - Department of Medical Laboratory Sciences, the First Affiliated Hospital of 
      Kunming Medical University, Kunming, China.
FAU - Guo, Jiazhi
AU  - Guo J
AD  - Biomedical Engineering Research Center, Kunming Medical University, 1168 West 
      Chunrong Road, Yuhua Avenue, Chenggong District, Kunming, 650500, Yunnan, China.
FAU - Lu, Di
AU  - Lu D
AD  - Technology Transfer Center, Kunming Medical University, 1168 West Chunrong Road, 
      Yuhua Avenue, Chenggong District, Kunming, 650500, Yunnan, China. 
      ludi20040609@163.com.
AD  - Biomedical Engineering Research Center, Kunming Medical University, 1168 West 
      Chunrong Road, Yuhua Avenue, Chenggong District, Kunming, 650500, Yunnan, China. 
      ludi20040609@163.com.
FAU - Li, Xiang
AU  - Li X
AD  - Department of Rehabilitation, Affiliated Hospital of Jining Medical University, 
      Jining, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - New Zealand
TA  - Mol Diagn Ther
JT  - Molecular diagnosis & therapy
JID - 101264260
RN  - 0 (MIRN196 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Smad3 Protein)
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 0 (mirn199 microRNA, human)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.11.1 (Oncogene Protein v-akt)
SB  - IM
MH  - Apoptosis/genetics
MH  - Cicatrix/drug therapy/*genetics/pathology
MH  - Extracellular Matrix/genetics
MH  - Humans
MH  - Keloid/drug therapy/*genetics/pathology
MH  - MicroRNAs/antagonists & inhibitors/*genetics
MH  - *Molecular Targeted Therapy
MH  - Oncogene Protein v-akt/genetics
MH  - Phosphatidylinositol 3-Kinases/genetics
MH  - Signal Transduction/genetics
MH  - Smad3 Protein/genetics
MH  - Software
MH  - Transforming Growth Factor beta1/genetics
EDAT- 2019/01/04 06:00
MHDA- 2019/06/21 06:00
CRDT- 2019/01/04 06:00
PHST- 2019/01/04 06:00 [pubmed]
PHST- 2019/06/21 06:00 [medline]
PHST- 2019/01/04 06:00 [entrez]
AID - 10.1007/s40291-018-0378-0 [pii]
AID - 10.1007/s40291-018-0378-0 [doi]
PST - ppublish
SO  - Mol Diagn Ther. 2019 Feb;23(1):53-63. doi: 10.1007/s40291-018-0378-0.